Cezirnate 500mg UPHACE medicine treats mild infections to fit the respiratory tract (2 blisters x 5 tablets)

Dosage form Box of 2 blisters x 5 tablets
Specifications Cefuroxime
Ingredient Sore throat, otitis media, sinusitis, urinary tract infections, urethritis, skin infections and soft tissue, acute bronchitis, pneumonia

Ingredient

Composition information	Content
Cefuroxime	500mg

Uses

Indications

CEZIRNATE 500 mg is indicated in the following cases:

Treatment of mild infections to fit the respiratory tract caused by sensitive bacteria: otitis media, recurrent sinusitis, tonsillitis, recurrent sore throat, outbreak of acute bronchitis with superinfection and infected pneumonia in the community.

Treatment of gonorrhea without complications and treatment of Lyme disease in the beginning manifested by the symptoms of erythematous erythema caused by Borrelia Burgdorferi. Bacteria are in the stage of growth and division by inhibiting the synthesis of bacterial cells. Like other 2nd generation cephalosporin antibiotics, cefuroxim has a better in vitro active activity than gram -negative bacteria than the first -generation cephalosporin antibiotics, but the spectrum on gram -negative bacteria is narrower than the 3rd generation cephalosporin antibiotics. Cefamandol, therefore, has a better effect on bacterial strains that produce beta lactamase such as Haemophyllus influenzae, Neisseria, Escherichia Coli, Entobacter, Klebsiella.

antibacterial spectrum:

Cefuroxim has a good and anaerobic gram -negative and anaerobic activity, including most staphylococcus strains of penicilinase, and gram -negative antibacterial activity. Cefuroxim has a high activity, so the minimum inhibitor (mic) has low inhibitors for streptococcus strains (group A, B, C and G), gonococcus and meningoccus strains. Initially, Cefuroxim also had low mic for gonococcus strains, Moraxella CatVrhalis, Haemophilus Influenzae and Klebsiella spp. Lactamase - Lactamase period. But now, in Vietnam, many bacteria have resisted Cefuroxim, so the mic of the drug for these strains has changed. En The strains of Clostridium Difficile, Pseudomonas spp., Campylobacter spp., Acinetobacter Calcoaceticus, Legionella spp. Are not sensitive to cefuroxim.

pharmacokinetic

absorption

After drinking, Cefuroxim acetyl is absorbed through the gastrointestinal tract and is quickly hydrolyzed in the intestinal and blood mucosa to release Cefuroxim into the circulatory system. The drug is best absorbed when taken at meals.

Distribution

about 33% to 50% of the blood cefuroxim in the blood binds to plasma proteins. Cefuroxim is widely distributed to organizations and fluids in the body. The apparent distribution volume in healthy adults ranges from 9.3 to 15.8 liters/1.73 MO. A small amount of Cefuroxim can pass through the brain blood barrier in case the meninges are not inflamed. However, Cefuroxim only achieves the concentration of treatment in cerebrospinal fluid when intravenous injection in case of meningitis. The drug through the placenta and excreted through breast milk.

Metabolism and elimination

Cefuroxim is not metabolized and eliminated in the form of non -variable according to the glomerular filtration mechanism and excreted in the renal tubules. Half of the lifetime elimination of the drug in plasma is about 1-2 hours. The drug is high in urine. Cefuroxim only excreted in honey with a very small amount.

Before taking Cezirnate 500mg UPHACE medicine treats mild infections to fit the respiratory tract (2 blisters x 5 tablets)

How to use

Cezirnate medicine is used for oral, should not crush the pill. Take medicine at meals to increase bioavailability.

Dosage

Adults:

The respiratory infection caused by sensitive bacteria: take 1 tablet, 12 hours. Treatment period of 10 days.

New lymphoma: take 1 tablet, 12 hours, for 20 days.

Inhabited gonorrhea: Take only 2 tablets.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Most drugs only cause nausea, vomiting and diarrhea. However, it can cause an increase in nervous stimulation and seizures, especially in people with kidney failure.

Handling

Protects the respiratory tract for patients, ventilation and infusion. If developing convulsions, stop using the drug immediately; Anti -seizures may be used if clinically indicated. Hemorrhage can eliminate blood from the blood, but most of the treatment is supporting or resolving symptoms.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Cezirnate 500 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

diarrhea, lumpy skin.

Uncommon, 1/1000

Anaphylaxis reactions, candidiasis infections, eosin cells prefer EOSIN, leukopenia, neutropenia, positive CoAMB testing; nausea, vomiting; urticaria, itching.

Rare, 1/10000

Fever; hemolysis anemia; Fake colitis, diverse roses, Steven - Johnson syndrome, poisoned epidermal necrosis, cholestatic jaundice, AST, alt, alkaline phosphatase, LDH and air bilirubin concentration; Acute renal failure and interstitial nephritis, hyperurine hyperurine, hypertrophy -fleeting creatinine, urinary tract infections, kidney pain, urethra or bleeding, difficulty urinating, vaginitis, vaginal candidiasis, itching and vaginal irritation; A seizure, headache, agitation, joint pain.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Contraindications in the following cases:

Patients with a history of allergies to antibiotics of cephalosporin.

Be cautious when using

Caution for patients with a history of allergies with the beta - lactam group.

should be cautious when giving patients simultaneously with strong diuretics, because it may have a adverse effect on kidney function.

should reduce the dose of cefuroxim injected in temporary or chronic kidney failure.

Using long -term cefuroxim can make non -sensitive strains grow too much. Need to follow the patient carefully. If the superinfection is serious during treatment, it is necessary to stop using the drug.

should be very careful when prescribing broad -spectrum antibiotics for people with gastrointestinal diseases, especially colitis.

During treatment, if convulsions should stop the drug and use appropriate epilepsy medications.

The ability to drive and operate machinery

has not recorded the effect of drugs on drivers and machinery operation.

Pregnancy

There is no control that has a complete control of the drug's safety in pregnant women and due to animal studies that are not always predictable to human response, so they only use this drug for pregnant women when they are really necessary.

Breastfeeding period

cefuroxim excreted in breast milk at low concentrations. The risk of unwanted effect on breastfeeding is not fully assessed, the ability to accumulate antibiotics in children is possible. Therefore, only use drugs for women who are breastfeeding after careful consideration of risks and benefits and must monitor children in the process of treating antibiotics for mothers.

Medicinal interaction

Probenecid high doses reduces Cefuroxim clearance in the kidney, making Cefuroxim concentration higher plasma and longer. kidney.

cefuroxim acetyl canal can affect the bacteria in the intestine, reducing estrogen reabsorption, thus reducing the effects of oral contraceptives containing estrogen and progesterone.

should use Cefuroxim acetyl at least 2 hours after antacids or H2 blockers, as these drugs can increase the gastric pH.

Storage

In a dry place, avoid light, temperature not exceeding 30 ° C.

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