Chamcromus skin ointment 0.03% Dopharma Treatment of eczema (10g)

Dosage form Box x 10g
Specifications Tacrolimus
Ingredient Central Pharmaceutical Joint Stock Company 2

Ingredient

Composition information	Content
Tacrolimus	0.03%

Uses

indicators

0.03% of the skin's skin ointment is indicated in the following cases:

attack treatment: used for children from 2 - 16 years old.

Short -term and interrupted treatment for eczema (organ dermatitis) from moderate to severe for children from 2 to 16 years old.

Has treated with other non -skin drugs that cannot be cured or other skin drugs are not recommended as corticosteroid skin.

Maintain treatment: Take medicine for both adults including the elderly and children 2 - 16 years old.

Preventing the outbreak of eczema (such as Eczema) with high frequency (over 4 times per year) and prolonging the disease.

Pharmacokology

ATC code: D11AH01

Division of drugs: Corticosteroid anti -inflammatory drugs

tacrolimus is a macrolid immunosuppressant that is extracted from streptomyces tsukubaensis that has the same immunosuppressive effect like cyclosporin but not related to the structure. The mechanism of immunosuppressive effects of Tacrolimus is not well known.

tacrolimus has the effect of inhibiting T cells T, through inhibition of Interleukin-2 production. Tacrolimus inhibits 100 times the immunosuppressor than the same dosage.

It has shown that Tacrolimus inhibits activating T lymphocytes by cohesion to an intracellular protein, FKBP-12. Tacrolimus-FKBP-12 complex, calcium calmodulin and calcinerurin ions are formed and inhibited phosphatase activity of calcinerurin and therefore has the ability to prevent phosphorylation and transfer of T-cells factor (NF-AT) to be activated, an ingredient of cell humanity through processing.

Tacrolimus also inhibits the transcription of genes with symbols IL-3, IL-4, IL-5, GM-CSF and TNF-A, all of these genes are involved in the activity process at the initial stage T.

It is also proved that Tacrolimus has the ability to inhibit the release of intermediate substances that have been formed from skin moisturizers, alkaline leukocytes and reduce the manifestations of high -pitched receptors on Langerhans cells.

tacrolimus is used to prevent transplantation of organization in liver, kidney, and heart transplant. The drug is also used to treat Crohn disease with holes and on -site treatment of allergies.

In patients with eczema, the recovery of skin damage while treating with Tacrolimus ointment is associated with a decrease in the cohesion of FC receptors on langerhans cells and reducing their stimulating activity to Tacrolimus ointments does not affect collagen synthesis in humans.

Dynamic pharmacokinetics

Clinical data shows that the concentration of Tacrolimus during the body circulation after use is low and when measured, it only feels transient. Data from healthy people show that there is no or very little exposure to the body with Tacrolimus when taking Tacrolimus ointment on the spot alone or repeating. Most organic eczema patients are treated with solitary or repeated Tacrolimus ointment (0.03 - 0.3%) with blood concentration in blood Due to the low exposure of the body with Tacrolimus ointment, the high cohesion of Tacrolimus (> 98.8%) with plasma proteins is considered as clinically unrelated

Tacrolimus metabolism in human skin has not been found. Tacrolimus in the body is completely metabolized in the liver via CYP3A4.

With the topical ointment, the average half -life of Tacrolimus is estimated at 75 hours for adults and 65 hours for children.

Before taking Chamcromus skin ointment 0.03% Dopharma Treatment of eczema (10g)

How to use

Chamcromus skin ointment 0.03% apply a thin layer of medicine to the sick area.

Dosage

attack treatment:

Used for children from 2 years old - 16 years old: only use 0.03%Chamcromus ointment. Starting with a thin layer of 0.03% Chamcromus ointment to the sick skin including facials and elbows and knees but must not be applied to the mucosa, apply twice a day in the morning and evening, apply a maximum of 3 weeks. Then apply the drug once a day, apply the minimum amount to completely control the sick area until the skin damage. If the disease recurs, apply Chamcromus medicine 0.03% 2 times.

Stop taking the drug when signs or symptoms of dermatitis have recovered after 1 week of treatment.

If the signs or symptoms of dermatitis (itching, burning, redness) do not improve after 2 weeks of treatment, patients should see a doctor again.

Apply medicine only to the sick skin according to the instructions of the physician because of the continuous and prolonged medication that causes Calcineurin inhibitors.

After applying the medication, this skin should not be bandaged.

Maintain treatment:

Used for patients responding to treatment for 6 weeks of drug treatment such as recovering, near or slightly affected skin damage.

Used for patients aged 16 and older including the elderly: Applying Chamcromus ointment 0.03% as directed by the doctor after the disease has helped.

For children: only 0.03%Chamcromus ointment. Apply Chamcromus 0.03% once a day, 2 times a week (for example, applying the drug on Monday and Thursday) to the skin area to prevent the disease from becoming acute. If the disease shows signs of acute recurrence, return to drug treatment as in the attack treatment. Time to use the drug is decided by the doctor but less than 12 months.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

How to handle: If the patient accidentally swallowed the drug, it could lead to overdose symptoms, see a doctor immediately for timely treatment: assessing signs of survival, clinical symptoms and supportive treatment.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Chamcromus 0.03% common effects (ADR) such as:

Common disorders and status at the position of drug use: burning, itching, irritation, irritation at the drug position.

Infections and parasites: Herpes virus infection, eye herpes, folliculitis, lip herpes, Kaposi chickenpox blister.

Disorders in the skin and tissue subcutaneous: itchy, local irritation, brown dots on the skin; Acne eggs, papillomas, skin discoloration, peeling, dry skin, edema at the position of applying medicine, lymphoma under the skin and other lymphoma tumors, skin cancer.

Disorders in the nervous system: Perception and sensory disorders (increased sensitivity, burning sensation).

Instructions on how to handle ADR:

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Chamcromus medicine 0.03% contraindicated in the following cases:

hypersensitively to the macrolid group in general, with tacrolimus or any ingredients of the drug. Or macrolid antibiotics such as azithromycin, clarithromycin, erythromycin, telithromycin.

adults with immunodeficiency.

Be cautious when used

Patients with eczema organs are susceptible to skin infections. If there is a clinical skin infection, the risk and benefits of the use of Chamcromus ointment should be 0.03%. Has recorded rare cases of malignant diseases including malignant diseases of skin and lymphas that have been reported in patients using Chamcromus ointment 0.03%.

During the use of Chamcromus 0.03%, skin exposure should be limited to natural light or artificial light.

Do not use Chamcromus 0.03% in patients with damaged skin protective barriers: Netherton syndrome, peeled psoriasis, body erythema.

If the signs, the organs of the eczema are not improved, the next use should be considered. Avoid contacting the eye or mouth, mucosa and open skin areas.

The effect of the drug on the ability to drive and operate machinery

unknown effects of the drug.

Use drugs for women during pregnancy and nursing mothers

Be cautious when using Chamcromus ointment in pregnant women. Drugs used with body secretion are not used in milk, so they do not use even external skin for nursing women.

Medicinal interaction

Modable interaction may occur when using drugs on wide skin. CYP3A4 metabolic inhibitors can affect the bioavailability of the drug such as bromocriptine, dexamethasone, erythromycin, ketoconazole, miconazole, omeprazole, ...

Should avoid using the drug simultaneously with UVA, UVB treatment therapy or combined with Psoralen (Puva).

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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