Chewing Kipel 4 mega We Care Preventive and treat chronic bronchial asthma, allergic rhinitis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Montelukast

Ingredient

Composition information	Content
Montelukast	4mg

Uses

indications

The drug is prescribed for treatment in children from 2 to 14 years old in the following cases:

Bronchial asthma: Preventive and treat chronic bronchial asthma. Ltd4 in asthma. With a lower doses of 5mg, significantly inhibitors of Ltd4 causes trachea.

Pharmacokinetics

absorption

Montelukast is quickly absorbed after drinking. In adults, after taking 10 mg film tablets at an empty stomach, the average peak concentration in plasma (CMAX) is achieved within 3-4 hours (TMAX). The average oral bioavailability is 64%. Oral and cmax is not affected by standard breakfast.

In children from 2 to 5 years old, using a 4 mg chewing tablet, the average cmax is achieved within 2 hours after chewing.

In adults, using a 5 mg chewing tablet at hunger, the average cmax is achieved within 2 - 2.5 hours after chewing. The average oral bioavailability is 73% and 63% when used with standard breakfast.

Distribution

over 99% Montelukast is connected to plasma proteins. Distribution voltage in an average stable state from 8 - 11 liters.

Metabolism

Montelukast is widely metabolized. In adults and children taking treatment dose, the concentration of metabolic substances of Montelukast in plasma in stable state cannot be detected.

Elimination

Montelukast clearance in plasma on average 45 ml in healthy adults. After taking Montelukast with radioactive marking, 86% of radioactive activity is found in the fertilizer collected for 5 days and less than 0.2% found in the urine. Combined with Montelukast's oral bioavailability shows that Montelukast and its metabolites are excreted mainly through the biliary tract.

Some studies show that Montelukast's average plasma sale time in healthy young people ranges from 2.7 to 5.5 hours. Montelukast's dynamic pharmacokinetics are almost linear with oral doses of up to 50 mg. When using 10 mg/day, only a small amount of drugs accumulated in plasma (14%).

Before taking Chewing Kipel 4 mega We Care Preventive and treat chronic bronchial asthma, allergic rhinitis (3 blisters x 10 tablets)

How to use

Kipel 4 mg chewing: Chewing and drinking with water.

Dosage

Treatment of chronic bronchial asthma

Montelukast should be used once a day in the evening with the following doses:

Children from 6 - 14 years old: 1 chewing 5 mg.

Children from 2 - 5 years old: 1 chewing 4 mg.

Children from 12-23 months of age: Please consult a doctor.

Safety and efficiency in children under 12 months of age have not yet been set up.

allergic rhinitis treatment

For allergic rhinitis, Montelukast should be used once a day. The effect has been shown for seasonal allergic rhinitis when using Montelukast in the morning or evening without having to relate to the time of meals. Time to use drugs depending on the needs of each object.

Children from 6 - 14 years old: 1 chewing 5 mg.

Children from 2 - 5 years old: 1 chewing 4 mg.

Safety and effectiveness in children under 2 years of age with unprocessed allergic rhinitis.

Treatment of bronchial asthma and allergic rhinitis

Patients with both bronchial asthma and allergic rhinitis should take 1 tablet daily in the evening.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

The most common reactions that occur are similar to the data of Montelukast's safety properties including abdominal pain, drowsiness, thirst, headache, vomiting and agitation.

Unknown Montelukast can be separated through the peritoneal or dialysis.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using the drug, you may experience unwanted effects (ADR).

Common side effects are headache, influenza, abdominal pain, cough, indigestion, hyperka, weakness, fatigue, dizziness, fever, gastritis, toothache, nasal congestion, rash, growth, pus urine.

In addition, the following adverse effects have also been reported:

Disorders of hematopoietic and lymphatic systems: tend to increase bleeding.

Immune system disorders: Anaphylaxis reaction, very rarely getting Eosin leukemia in the liver.

Mental disorders, agitation include aggressive attitude or opposition, or anxiety, depression, abnormal dreams, hallucinations, insomnia, irritation, hyperactivity, sleepwalking, thoughts and actions that want to suicide (including suicide), Run.

Nervous system disorders: drowsiness, paresthesia/decrease sensation, convulsions.

Heart disorders: Brushing the chest.

Respiratory, chest and mediastinum disorders: Nose bleeding.

Gastrointestinal disorders: diarrhea, indigestion, nausea, very rare pancreatitis, vomiting.

Hepatic disorders: rare cholestatic hepatitis, liver cell damage, and multi -component liver damage have been reported in patients treated with Montelukast. Most of these side effects occur when combined with other disturbing agents such as simultaneous use with other drugs, or using Montelukast in patients at risk of liver disease such as drinking alcohol or other hepatitis.

Skin and subcutaneous tissue disorders: Evana, bruises, erythema, itching, urticaria.

Musculoskeletal and connective tissue disorders: joint pain, muscle pain including cramps.

Systemic disorders and medication condition: edema.

Notice immediately to the doctor or pharmacist about unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Contraindications in the case of patients sensitive to any ingredient of the drug.

Caution when using

General recommendations

Do not use Montelukast in the treatment of bronchospasm during acute asthma attacks, including asthma. Patients should be instructed to use the appropriate treatment. Montelukast can be continued during severe asthma attacks. Patients with severe asthma due to exertion need to have the owner of the 8-AMYist) inhaled, short effect to save.

may have to reduce inhaled corticosteroids gradually under the supervision of a physician, but not to suddenly replace inhaled corticosteroids or drink with Montelukast.

In patients with aspirin sensitivity, aspirin should not be taken or other nonsteroidal anti -inflammatory drugs while taking Montelukast. Although Montelukast has the effect of improving the respiratory function in patients with asthma sensitive to aspirin, it has not yet been shown to be removed from the bronchospasm caused by aspirin and other nonsteroidal anti -inflammatory drugs in Aspirin sensitive asthma patients.

Mental - Mental effects

There have been reports on mental neurological disorders in patients who take Montelukast, including adults, teenagers and children. Symptoms have been reported including agitation, aggressive or hostile attitudes, anxiety, depression, abnormal dreams, hallucinations, insomnia, irritation, hyperactivity, sleepwalking, thoughts and actions that want to suicide (including suicide) and tremor.

Doctors and patients need to be vigilant about mental - mental disorders that can occur. It is necessary to guide the patient to notify the doctor if these symptoms are encountered.

Doctors should be cautious about the risk and benefits of continuing to appoint Montelukast when the symptoms occur.

Eosin eosinophilia

Some rare cases of patients with bronchial asthma treated with Montelukast may have eosin hypernagus, sometimes the symptoms of vascular inflammation of Churg-Strauss syndrome when reduced corticosteroid dose using systemic sugar.

Magical phenylketon

Patients with chemical phenylketon should be informed that in chewing 4 mg and 5 mg contains phenylalanin (in the composition of aspartam), each chewing 4 mg and 5 mg contains the corresponding (0.674 and 0.842 mg phenylalanin).

The ability to drive and operate machinery

Be cautious when driving because the drug can cause headaches, dizziness, fatigue, insomnia, hallucinations.

Pregnancy

There is no adequate and well -controlled research on pregnant women. Montelukast is only used for pregnant women when really necessary.

The period of breastfeeding

It is unclear Montelukast's excretion through breast milk. Caution should be careful when taking the drug during breastfeeding.

Drug interaction

No need to adjust the dose when using Montelukast and Theophylllin, Prednison, Prednisolon, Oral contraceptives, Terfenadin, Digoxin, Warfarin, Thyroid Hormone, Non -Spring anti -inflammatory drugs, Benzodiazepin, nose pine, and enzyme inductors P450 (CYP).

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children.

Other drugs

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