Chewing Pentinox 400mg SPM treats diseases of parasites, worms, tapeworms (1 tablet)

Dosage form 1 tablet box
Specifications Albendazole

Ingredient

Composition informationContent
Albendazole400mg

Uses

Indications

Pentinox Pentinox 400mg is indicated in the following cases:

  • Infection of one type or more intestinal parasites such as roundworm, needle worm, hairworms, hookworms, worms, melon seeds (Hymenolepis Nana), Tapkin Solium (Taenia Solium), cowbow (T.Saginata), Opisthorchis Viverrini and O.Sinensis.

    • Albendazole is also effective on immigration larvae in the skin, infection of tapeworm larvae in the brain (neurocysticercosis).

    Folliculum infection.

    Pharmacy

    Albendazole is a substance of benzimidazole carbamat, in terms of structure related to Mebendazol. The drug has a broad -active spectrum on intestinal worms such as hookworms (Ancylostoma duodenale, roundworm (Ascaris lumbricoides), needle worms (enterobius vermicularis), SEA worms (Strongyloides Stercoralis), Hairworm (Trichuris Trichuriura), Capillaria (Capillaria Philippian (Trichinella Spiralis) and migration larvae in the skin and muscles, turbulent tapelines and tissue larvae (such as echinococcus granulosus, e.multoLocularis and E.Neurocysticervosis).

    Albendazole is active in both adult and larvae stage of intestinal worms and eliminates the eggs of roundworms and hair worms. The main metabolic form of albendazol is Albendazol Sulfoxid still works and holds an important position of the pharmacological effect of the drug.

    The main acting mechanism of albendazole is similar to other benzimidazols. The drug is associated with the sub -parasites, thereby inhibiting the coincidence of the sub -sub -sub -submarine to the minimum of the cytoplasm is essential for the normal activity of the parasitic cell

    pharmacokinetic

    absorption

    In humans, after drinking, Albendazole is very absorbed very poorly (5%). Most anti -helminth effects occur in the intestine. To have the effect of tissue, high and long -term doses must be used. Due to the steps of metabolism, it is not seen to see Albendazole or only see in the form of traces in the wound.

    After taking a single dose of 400mg of Albendazole, the peak concentration of sulfoxid metabolites achieved in plasma is about 0.04 - 0.55mcg/ml after 1 hour to 4 hours. When taking the drug with greasy foods, plasma concentrations increase to 2-4 times. There is a great difference between individual concentrations of albendazole sulfoxid in plasma. It may be due to erratic absorption and due to the difference in the speed of drug metabolism.

    Distribution

    Albendazole Sulfoxid binds to protein in plasma up to 70%. When used for long -term use in the treatment of tapeworms, albendazole sulfoxid levels in tapeworm fluid can reach about 20% of plasma concentrations. Albendazole sulfoxid through the brain -marrow barrier is about 1/3 of the plasma concentration.

    Metabolism

    Albendazole is rapid and completely oxidized, into metabolites that still have the effect of Albendazole Sulfoxid, then converted into a compound that no longer works as Albendazole Sulfon.

    Elimination

    Albendazole has half -life eliminated from plasma for about 9 hours. Sulfoxid metabolism is eliminated through the kidneys along with sulfon metabolites and other metabolites. A negligible amount of sulfoxid metabolism is excreted through bile.

    Before taking Chewing Pentinox 400mg SPM treats diseases of parasites, worms, tapeworms (1 tablet)

    How to use

    You can chew, swallow or grind and mix with food. No need to fast and eraser.

    Dosage

    roundworms, needle worms, hookworms, hairworms

    Adults and children> 2 years old

    Take a single dose of 400mg. Can be treated after 3 weeks.

    Children 1 - 2 years old

    Take a single dose of 200mg. Can be repeated after 3 weeks.

    immigrant larvae in DA

    Adults

    Take 400mg x 1 time/day, drink 3 days.

    Children

    Take 5mg/kg/day, drink 3 days.

    capsule

    Adults

    Take 800mg daily, drink for 28 days. Repeat treatment if needed.

    Children 6 years of age and older

    Take 10 - 15mg/kg/day, drink for 28 days. Repeat treatment if needed.

    Children under 6 years old

    Unmetized dosage.

    Tapeworm larvae in the brain

    Adults

    Take 5mg/kg/day for 30 days. Repeat treatment after 3 weeks if needed.

    Children

    Review adult dose.

    Strongyloides

    Adults and children> 2 years old

    Take 400mg x 1 time/day, drink 3 days. Repeat treatment after 3 weeks if needed.

    Children 1 - 2 years old

    Take 200mg x 1 time/day, drink 3 days. Repeat treatment after 3 weeks if needed

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose? Rarely severe reactions, including granulocytes, granulocytes, or hemophilia. Blood formula must be tested at the beginning of the treatment cycle every 28 days and every 2 weeks during treatment. Continuing to be treated with albendazole if the leukemia decreases small and does not worsen.

    Albendazole may increase liver enzyme from a moderate level in 16% of patients, but return to normal when stopping treatment. Liver function testing (transaminase) must be conducted before starting each treatment cycle and at least every 2 weeks during treatment. If the liver enzyme increases a lot, albendazole should be stopped. It may be treated with albendazole when the liver enzyme returns to the level before treatment, but need more tests when re -treatment.

    Patients are treated with tapeworm larvae with brain damage, should use more corticosteroids and anti -convulsions. Take or intravenously corticosteroids will prevent the intracranial hypertension in the first week when treating this tapeworm disease.

    Inhaled larvae with brain damage (neurocystic - errosis), which may affect the retina, though very rare. Therefore, before treatment, the retinal damage should be tested. If there is already a retinal damage, it is advisable to consider the benefits of treatment compared to the damage of the retina caused by Albendazole.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    Side Effects

    When using Pentinox 400mg, you may experience unwanted effects (ADR).

    There is a lack of clinical trials that have a wide range of tests to better assess the safety of the drug. When treating for a short time (no more than 3 days), some cases are uncomfortable in the digestive tract (epigastric pain, diarrhea) and headache. In the treatment of tapeworms and tapeworm larvae with brain damage (neurocysticercosis) are cases of high and long -term doses, harmful effects are more common and worse. Usually unwanted effects are not severe and recover without treatment. Only stop treatment when leukemia (0.7%) or liver abnormalities (3.8% in tapeworm disease).

    Common, ADR> 1/100

  • Fever, headache, dizziness, brain manifest, increased pressure in the brain, normal liver function, abdominal pain, nausea, vomiting, hair loss (recovery).

    • Uncommon, 1/1000

  • Allergic reactions, leukopenia, skin rash, urticaria, acute renal failure.

    • Rare, ADR

  • Grain leukopenia, general hematuria, grain leukemia, plateletal reduction

    • Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Pentinox 400mg drug contraindicated in the following cases:

  • There is a history of hypersensitivity to benzimidazol group compounds.

    • Too hypersensitivity to any ingredients of the drug.

    History of bone marrow poisoning.

  • Pregnant women.

    • Be cautious when using

  • Patients with abnormal liver function before treatment with albendazole need to consider carefully because the drug is metabolized in the liver and has seen patients infected with liver toxicity.
  • Be careful with people with blood.

    • The ability to drive and operate machinery

    should be cautious when taking the drug if you need to drive or operate machinery because the drug can cause dizziness.

    Pregnancy

    should not use Albendazole for pregnant women except for cases of mandatory use without any other way. Patients must not be pregnant after at least 1 month of using Albendazole. If the patient is taking the drug and if he is pregnant, he/she must stop immediately and understand that the drug can cause serious danger to the fetus.

    Breastfeeding period

    still do not know what level of the drug in milk. Therefore, it is necessary to be very careful when using albendazole for breastfeeding women.

    Drug interaction

    Dexamethason

    The lowest stable concentration in the plasma of Albendazol Sulfoxid is about 50% higher when used in combination with an additional 8mg of dexamethason with each dose of Albendazole (15mg/kg/day).

    Prazancelel

    Praziquantel (40mg/kg) increases the average concentration in plasma and area under the curve of Albendazole Sulfoxid about 50% compared to using single albendazole (400mg).

    cimetidine

    Albendazole sulfoxid concentration in bile and in tapeworm fluid increased by about twice in people with capsule when used in combination with cimetidine (10mg/kg/day) compared to using single albendazole (20mg/kg/day).

    Theophylin

    pharmacokinetics of theophylin (transmitted for 20 minutes theophylin 5.8mg) unchanged after taking 1 time albendazole (400mg).

    Storage

    The drug needs to be stored in a dry place, avoiding light, temperatures below 30 ° C.

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