Chewing Saferon Glenmark prevent and treat iron deficiency anemia (3 blisters x 10 tablets)

Dosage form Chewing tablet
Specifications Box of 3 blisters x 10 tablets
Ingredient Fe (III), folic acid

Ingredient

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Composition informationContent
Fe (III)100mg
Folic acid500mcg

Uses

Indications

Saferon chewing pills are indicated in the following cases:

Adults

Preventive and treatment of iron deficiency anemia, such as anemia is weak during pregnancy and breastfeeding, anemia due to chronic or acute blood loss, due to diet, metabolic or recovery after adult surgery; Combining IPC - Folic acid suitable for iron and folic supplements for women at the age of reproductive age and during pregnancy.

Children

Preventive and treatment of iron deficiency anemia due to chronic or acute blood loss, nutritional deficiency, metabolic disease in children.

Pharmacokology

Hydroxid Polymaltose iron complex (III)- IPC

iron salts, including IPC, plays an important role in treatment as well as prevent iron deficiency anemia. The body reserves iron in the form of ferritin and hemosiderin to create hemoglobin. IPC IPC iron core of IPC is surrounded by many polymaltose molecules that form a large molecule with a molecule of about 52300 dalton, so large that its diffusion through the mucosal membrane is about 40 times less than iron salt (II). Iron in IPC core is linked to the same structure as Ferritin. IPC, also known as iron polymaltose hydroxide complex (III), is different from iron (II) sulfate thanks to high safety and low toxicity due to no free iron ions. IPC is a complex of iron III Hydroxid in combination with a food additive, polymaltose.

Its iron ionized ionization helps the stomach are less irritated than conventional iron salts, helping patients tolerated better, a very important point in the long -term treatment of iron deficiency anemia with iron -containing preparations. The effectiveness of IPC in the prevention and treatment of iron deficiency anemia has been proven in clinical trials. Hemoglobin value increases faster when using IPC compared to conventional iron salts. When using IPC, the hemoglobin value increased to 0.8mg/dl per week. In addition, there is a faster increase than hematocrit, MCV, serum and ferritin.

Folic acid

Folic acid is a B vitamins B in the body, it is reduced to tetrahydrofolate, a coenzyme of many metabolic processes, including synthesis of nucleotid purines and pyrimidine, and DNA synthesis, participating in the transformation of some amino acids. Studies show that folic acid provides sufficient folic acid for women of reproductive age to reduce the risk of children with vertebrae or brain -free monsters. Therefore folic acid is used for women who are likely to become pregnant and pregnant women to reduce the risk of neural tube defects in the fetus.

Lack of folic acid can cause enlarged red blood cell anemia, which appears when the supply is not sufficient (nutritional deficiency), absorption disorders (such as an inflammation of an oral ulcer), increased use (pregnant women or some diseases such as hemolytic anemia), increased loss (such as when hemorrhage), or due to use of antagonistic drugs or affect folat metabolism. Folic acid is used to prevent and treat folic acid deficiency. It is not used to treat folat deficiency due to dihydrofolat reductase inhibitors, this case must use calcium folinat.

pharmacokinetic pharmacokinetics

When the Hydroxide Polymaltose iron (III) - IPC is exposed to the cohesive positions with iron on the mucosa surface, it will release the three and proactive iron ions into the mucous membranes by a carrier protein and are stored in the mucous membranes in the form of ferritin or carried by the gills in which the bloody protein is tried With transferrin.

IPC bioavailability is equivalent to iron salt II in experimental animals and in people with hemoglobin synthesis. IPC's bioavailability when drinking is not affected by food ingredients such as phytic acid, oxalic acid, tannin, sodium alginate, cholin salts, vitamin A, D3, E, soybean oil and flour, unlike conventional iron salts, IPC complex iron into the serum thanks to endogenous proteins, with a waste time of about 90 minutes, then go into the endothelium of the liver or combine with transferrin,, transferrin mesh Apoferritin, into the bone marrow or spleen to create red blood cells.

iron in regular iron preparations is iron II ions, which can easily cause stomach irritation. The absorption of iron ions II is passive and uncontrolled, which can cause excess iron and toxic to the body. IPC has better safety because iron is not ionized at least causing stomach irritation, and has little pharmacokinetic interaction with other substances like conventional iron salts.

Folic acid is quickly absorbed from the digestive tract, mainly from duodenum and ileum. Folat in food is about half of the crystallized folic acid. Folic acid when taken into the bloodstream is mainly in a constant form because it is less reduced by Dihydrofolate Reductase. It is transformed into a 5-methylhydrofolate activity form in plasma and liver. The liver is the main folat reserve. Folat also has high concentrations in cerebrospinal fluid. Folat goes into the liver circulation. The metabolites of folats are eliminated in the urine. The excess folat is also eliminated in the form of unchanged urine. Folat goes into breast milk, and can be eliminated by hemorrhage.

Before taking Chewing Saferon Glenmark prevent and treat iron deficiency anemia (3 blisters x 10 tablets)

How to use

daily dose can be divided into small or disposable doses. Chew or take Saferon tablets after eating to have the best effect.

Dosage

Dosage and treatment time depending on the level of iron deficiency.

When the hemoglobin value is returned to normal, it is necessary to continue treating for an additional 3 months to supplement the amount of iron reserves.

dose calculated by IPC (mg)/day:

  • Children under 12 years old but large enough to be able to swallow the pill: 50 - 100mg (1/2 - 1 tablet)/day. members)/day.

    • Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when using overdose? Saferon chewing is generally safe.

    IPC's iron absorption is less, but IPC has better gastrointestinal intake, along with a higher IPC safety, which can be important to reduce the risk of iron overdose. Although IPC is safer than iron salts (II) inorganic, can still overdose but rare. Symptoms of iron overdose include fatigue, nausea, vomiting, abdominal pain, stools such as darkness, fast and weak pulse, fever, coma, convulsions and death. Need emergency immediately if iron overdose.

    Folic acid: Folic acid is very safe because it is a water -soluble vitamin, even with a very high dosage, with a very low risk of toxicity. If overdose, symptomatic treatment and support treatment. If there is anaphylactic reaction, apply the standard treatment. When accidentally taken, there must be large amounts, within 1-2 hours can wash the stomach or cause vomiting. Can drink activated carbon.

    What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

    Side Effects

    When using Saferon, you may experience unwanted effects (ADR).

    Unknown frequency ADR:

    Digestive: epigastric pain, metal, nausea, vomiting, abnormalities, constipation, diarrhea, black stool.

    Other: Change tooth color.

    Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Saferon drugs contraindicated in the following cases:

  • Patients with hypersensitivity to any ingredients of the drug.

    Caution when using

    IPC:

    Overdose of iron -containing drugs can cause poisoning leading to death in children under 6 years old. Although Saferon is quite safe because the IPC has a very high LD50, it must be left for the medicine at the reach of children. If you accidentally overdose, call your doctor or the anti -toxic center immediately.

    Iron -containing drugs, including iron -polymaltose hydroxid (III), can cause allergic reactions or anaphylaxis. If anaphylactic reaction must stop using Seferon immediately and apply emergency measures.

    Do not overdose indicated. The treatment of anemia must follow the instructions and monitoring of the doctor. Sometimes discomfort in the gastrointestinal tract (such as nausea), can be minimized by taking medicine with food. Iron -containing drugs can sometimes cause constipation or diarrhea.

    Be cautious when used for people with allergies, liver failure or kidney failure.

    Be cautious when used for alcoholics and people with gastrointestinal diseases such as gastrointestinal ulcers, colitis.

    Folic acid:

    Folic acid dose above 0.1mg/day can cover the symptoms of malignant anemia (unknown hematological manifestations while the nerve manifestation is still progressing).

    Do not use solitary folic acid or with insufficient amount of vitamin B12 to treat large red blood cell anemia, because folic acid can produce hematology in patients with large red blood cell anemia due to vitamin B12 deficiency but do not prevent the progression of neurological symptoms, which can lead to serious neurological damage, such as spinal degeneration.

    Should be cautious when used for patients with folat tumors.

    Be cautious when used for patients with renal failure.

    The ability to drive and operate machinery

    does not affect.

    Pregnancy

    iron supplements - Folic acid is known to be safe and beneficial for both mother and child.

    Breastfeeding period

    Do not know if the IPC goes into breast milk. Folic acid goes into breast milk and does not have any unwanted effects to be seen in breastfed babies when mothers use folic acid. Only use Saferon chewing tablets for breastfeeding women when really necessary.

    Drug interaction

    IPC:

    Because iron in IPC is in the form of complex links, the interactions between iron ions and ingredients of food (such as phytin, oxalate, tannins, etc.) and other oral medications (tetracyclin, antacids) are less likely. Like other iron drugs, IPC can also reduce the absorption of some drugs. IPC should not be taken within 2 hours after taking the following drugs: Tetracyclin, fluoroquinolon, chloramphenicol, cimetidine, levodopa, levothyroxin, methyl dopa, penicillamin.

    The cohesive antacids can be separated from IPC within 3 to 8 pH, different from inorganic iron salts, which are sustainable bonding without separation; But antacids can reduce IPC absorption. Do not take antacids within 2 hours after using IPC. There is no interaction between hormones and IPCs (like conventional iron medications).

    Folic acid:

    Folic acid deficiency can be caused by some drugs such as anti -epilepsy, oral contraceptives, tuberculosis, alcohol, folic antacids such as methotrexate, pyrimethamine, triamteren, trimethoprim and sulfonamide. In some cases such as when using anti -epileptic drugs and methotrexate, may need therapy with folinic acid or folic acid to prevent the appearance of large red blood cell anemia. Folic acid supplements have been reported to reduce serum phenytoin levels in some cases, and may also occur with anti -epileptic barbiturates.

    • Storage

    Store at 25 degrees C. Avoid moisture and light.

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