Chitogast 30 Boston medicine treats symptoms of acute and chronic osteoarthritis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Etoricoxib
Ingredient Dysmenorrhea, back pain, joint inflammation, arthritis, rheumatoid arthritis, bone inflammation

Ingredient

Composition information	Content
Etoricoxib	30mg

Uses

Indications

Chitogast 30 mg 3x10 Bostonpharma is indicated in the following cases:

Treatment of symptoms of acute and chronic osteoarthritis. High filter for COX-2 inhibition. Cycloxease concentration (COX-2) high in inflamed tissues leads to the synthesis of prostaglandins is the intermediate substance of the process of pain and inflammation. The mechanism of action of Etoricoxib is thought to be due to inhibition of the synthesis of protaglandins mainly via COX-2. In the treatment concentrations in human plasma, Etoricoxib does not inhibit COX-1.

Dynamic pharmacokinetics

Etoricoxib orally reach 100% biological and time to reach the peak concentration in plasma is an hour. About 90% of protein -mounted drugs do not cause significant changes in the level and absorption speed when used with food. Etoricoxib is metabolized mainly in the liver by Cytochrome P450 (CYP) -3A4 and is excreted in the urine, mainly in the form of metabolites in which no specialized substances have significant Cox-2 or COX-1 inhibitors. Etoricoxib's waste sale time is 22 hours.

Before taking Chitogast 30 Boston medicine treats symptoms of acute and chronic osteoarthritis (3 blisters x 10 tablets)

How to use

by oral, drink before or after meals.

Dosage

Adults

osteoarthritis: 30 mg/time/day. Increase dose 60 mg/day/day if symptoms do not decrease.

rheumatoid arthritis, stiff spine inflammation: 90 mg/day.

Acute arthritis caused by gout: 120 mg/day, use up to 8 days.

Chronic analgesic: 60 mg/time/day.

Acute analgesic, prospective dysmenorrhea: 120 mg/time/day.

Children and adolescents

Not recommended if under 16 years old.

Patients with liver failure

Patients with mild liver failure: 60 mg/day/day.

Patients with medium liver failure: 30 mg/day/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose?

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Chitogast 30 mg 3x10 Bostonpharma, you may experience unwanted effects (ADR).

No frequency mentioned:

Neurological: taste disorders, blurred vision, restless anxiety, insomnia or sleep, hallucinations ...

circulatory: thrombocytopenia, congestive heart failure, hematoma, angina, tachycardia, drama hypertension ... Respiratory: Bronchospasm. digestive: abdominal pain, gastrointestinal ulcer, nausea, diarrhea, jaundice hepatitis ... Urology: Disability of kidney, including renal failure. Metabolism and immunity: Hypersensitivity reactions, anaphylactic reactions, hyperkalemia, in addition can cause: itching, urticaria, erythema, angioedema.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Chitogast 30 mg 3x10 Bostonpharma is contraindicated in the following cases:

Patients with hypersensitivity to Etoricoxib or any ingredients of the drug.

Patients with gastrointestinal ulcers or acute gastrointestinal bleeding.

Patients with severe liver failure or creatinine clearance is lower than 30 ml/min.

Patients with intestinal diseases and Sung - severe blood failure.

Ischemic heart disease, peripheral artery disease, brain vascular disease have been identified.

Children and adolescents under 16 years old.

Pregnant and lactating women.

Be cautious when used

Use cautiously in patients with significant risk factors for cardiovascular events (such as hypertension, diabetes, hyperlipidemia, smoking ...).

When treated with Etoricoxib, especially at high doses, regular blood pressure monitoring and if the blood pressure is significantly high, it is necessary to replace other treatment directions because Etoricoxib can coordinate with more frequent and serious hypertension than some NSAIDs and other COX-2 selective inhibitors.

Use Etoricoxib carefully with patients with significant dehydration and should rehydration before use.

Caution should be used with careful anti -hypertension drugs when the patient shows signs of heart failure, impaired left ventricular function and previous edema.

For patients with liver, kidney or heart dysfunction and elderly patients must be closely monitored and when there is a worsening manifestation, they must take appropriate handling measures immediately including stopping treatment with this drug.

Use cautiously Eoricoxib in patients with a history of perforation, ulcers, gastrointestinal bleeding and patients over 65 years old.

The ability to drive and operate machinery

After taking the patient's medicine, the patient may be dizzy and drowsy, so limit driving and operating machinery.

Pregnancy

Contraindications for pregnant and lactating women.

Breastfeeding period

Contraindications for pregnant and lactating women.

Drug interaction

warfarin: In patients who have been treated stably with warfarin, using Etoricoxib 120 mg daily can lead to an increase of about 13% of prothrombin compared to international standard ratios (INR). Inr valuable control should be strictly controlled when starting with Etoricoxib, especially in the first days, when the patient is using warfarin or similar substances.

Rifampin: Concomitant use of Etoricoxib with rifampin, a agent capable of causing metabolic enzyme induction in strong liver, reducing 65% of the area under the curve (AUC) in the plasma of Etoricoxib. This interaction should be taken into account when Etoricoxib is used with rifampin.

methotrexate: Methotrexate toxicity monitoring should be monitored when used simultaneously Etoricoxib at a dose of 90 mg daily and methotrexate.

Angiotensin (ACE) inhibitors: There have been reports on acknowledging non-selective NSAIDs inhibitors and selective Cox-2 inhibitors can reduce the anti-hypertension effect of ACE inhibitors.

Lithium: There has been a report that acknowledges that NSAIDs inhibitors are not selective and COX-2 inhibitors may increase plasma lithium concentration.

Aspirin: Concomitant use of low -dose aspirin with Etoricoxib can lead to the increase in gastrointestinal ulcers and other complications compared to the case of Etoricoxib only.

Oral oral medications: Etoricoxib treatment of 120 mg with a oral drug to avoid conception containing 35 mcg ethinyl estradiol (EE) and 0.5 to 1 mg norethindrone for 21 days, simultaneous use or 12 hours apart, increasing AUC 0 - 24 hours in the stable state of EE to 50 to 60%.

Other drugs: Etoricoxib does not have an important clinical effect on the pharmacokinetics of Prednisone/Prednisolone or Digoxin.

Storage

In closed packaging, dry place, below 30 ° C, avoid light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.