Chitogast 60 Boston treats symptoms of acute and chronic osteoarthritis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Etoricoxib
Ingredient Ischemic anemia, liver failure, kidney failure, intestinal disorders, digestive ulcers, drug allergies, heart failure

Ingredient

Composition information	Content
Etoricoxib	60mg

Uses

indications

chitogast drugs are indicated in the following cases:

Treatment of symptoms of acute and chronic osteoarthritis. High filter for COX - 2 inhibition. Cycloxygevaase (COX - 2) concentration at inflamed tissues leads to the synthesis of Prostaglandins is the intermediate substance of the pain and inflammation process. The mechanism of action of Etorieoxib is thought to be due to inhibition of the synthesis of protaglandins mainly through COX - 2. In the concentrations of treatment in human plasma, Etoricoxib does not inhibit COX - 1.

Dynamic pharmacokinetics

Etorieoxib orally reach 100% biological and time to reach the peak concentration in plasma is an hour. About 90% of protein -mounted drugs do not cause significant changes in the level and absorption speed when used with food. Etorieoxib is metabolized mainly in the liver by Cytochrome P450 (CYP) - 3A4 and is excreted in the urine, mainly in the form of metabolites in which no metabolites have a significant Cox - 2 or COX - 1 inhibitor. Etoricoxib's waste sale time is 22 hours.

Before taking Chitogast 60 Boston treats symptoms of acute and chronic osteoarthritis (3 blisters x 10 tablets)

How to use

oral, oral or after meals.

Dosage

Adults

Osteoarthritis: 30 mg/time/day. Increase dose 60 mg/day/day if symptoms do not decrease.

Rheumatoid arthritis, stiff spondylitis: 90 mg/day/day.

Acute arthritis due to gout: 120 mg/day/day, use up to 8 days.

Chronic analgesic: 60 mg/day/day.

Acute analgesic, abolished dysmenorrhea: 120 mg/day/day.

Children and adolescents

It is not recommended if under 16 years old.

Patients with mild liver failure: 60 mg/day/day.

Patients with medium liver failure: 30 mg/day/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Chitogast, you may experience unwanted effects (ADR).

On the nervous system: taste disorders, blurred vision, restless anxiety, insomnia or sleeping, hallucinations ...

On the circulatory system: platelet reduction, congestion heart failure, brushing chest, angina, tachycardia, drama hypertension ...

On the respiratory system: bronchial spasm.

On the digestive system: abdominal pain, gastrointestinal ulcer, nausea, diarrhea, jaundice ...

On the urinary system: Disability of kidney, including renal failure.

The immune and metabolic system: hypersensitivity reactions, anaphylactic reactions, hyperkalemia.

In addition, it can cause: itching, urticaria, erythema, angio ...

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Chitogast drug contraindicated in the following cases:

Patients with hypersensitivity to Etoricoxib or any ingredients of the drug.

Patients with gastrointestinal ulcers or acute gastrointestinal bleeding.

Patients with severe liver failure or creatinine clearance is lower than 30 ml/min.

Patients with severe intestinal diseases and congestive heart failure.

Ischemic heart disease, peripheral artery disease, brain vascular disease have been identified.

Children and adolescents under 16 years old.

Pregnant and lactating women.

Be cautious when used

Use cautiously in patients with significant risk factors for cardiovascular events (such as hypertension, diabetes, hyperlipidemia, smoking ...).

When treated with Etoricoxib, especially at high doses, regular blood pressure monitoring and if the blood pressure increases significantly, it is necessary to replace other treatment directions because Etoricoxib can coordinate with more frequent and serious hypertension than some NSAIDs and other COX -2 selective inhibitors.

Use Etoricoxib cautiously with patients with significant dehydration and should rehydration before use.

Need to use carefully anti -hypertension drugs when the patient shows signs of heart failure, impaired left ventricular function and previous edema.

For patients with liver, kidney or heart dysfunction and elderly patients must be closely monitored and when there is a worsening manifestation, they must take appropriate handling measures immediately including stopping treatment with this drug.

Use cautiously Eoricoxib in patients with a history of perforation, ulcers, gastrointestinal bleeding and patients over 65 years old.

The ability to drive and operate machinery

After taking the patient's medicine, the patient may be dizzy and drowsy, so limit driving and operating machinery.

Pregnancy

Contraindications for pregnant women.

Lactation period

Contraindications for breastfeeding women.

Drug interaction

Warfarin: In patients who have been treated stably with warfarin, using Etoricoxib 120 mg daily can lead to an increase of about 13% of prothrombin compared to international standard ratios (INR). The Inr price strict control should be strictly controlled when starting with Etoricoxib, especially in the first days, when the patient is using Warfarin or the same substances.

Rifampin: Concomitant use of Etoricoxib with rifampin, a agent capable of causing metabolic enzyme induction in strong liver, reducing 65% of the area under the curve (AUC) in the plasma of Etoricoxib. This interaction should be taken into account when Etoricoxib is used with rifampin.

methotrexate: Methotrexate toxicity monitoring should be monitored when used simultaneously Etoricoxib at a dose of 90 mg daily and methotrexate.

Angiotensin (ACE) inhibitors: There have been reports on acknowledging non -selective NSAIDs inhibitors and selective Cox - 2 inhibitors can reduce the anti -hypertension effect of ACE inhibitors.

Lithium: There has been a report that acknowledges the non -selective NSAIDs inhibitors and COX - 2 inhibitors can increase plasma lithium concentration.

Aspirin: Concomitant use of low -dose aspirin with Etoricoxib can lead to the increase in gastrointestinal ulcers and other complications compared to the case of Etoricoxib only.

Oral oral medications: Etoricoxib treated with a dose of 120 mg with a oral drug to avoid 35 mcg ethinyl estradiol (EE) and 0.5 to 1 mg norethindrone for 21 days, simultaneous use or 12 hours apart, increasing AUC0 - 24 hours in the stable state of EE to 50 to 60%.

Other drugs: Etoricoxib does not have an important clinical effect on the pharmacokinetics of Prednisone/Prednisolone or Digoxin.

Storage

In closed packaging, dry place, less than 300C, avoid light.

Other drugs

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