Chloramphenicol 250mg Mekophar treats severe bacterial infections caused by sensitive bacteria (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Chloramphenicol
Ingredient Inflammation, typhoid

Ingredient

Composition information	Content
Chloramphenicol	250mg

Uses

Indications

Chloramphenicol 250mg drugs are indicated in the following cases:

Treatment of severe bacterial infections caused by sensitive bacteria, due to Rickettsia, Chlamydia when the less toxic drugs are not effective or contraindicated.

intestinal infections such as typhoid deputy.

chloramphenicol inhibits in vitro sensitive bacteria at a concentration of 0.1 - 20microgam/ml.

chloramphenicol is acting on heavy bacterial infections caused by sensitive bacteria, caused by rickettsia, chlamydia.

chloramphenicol has no effect on mushrooms.

antibacterial spectrum includes

GR (+): Staph. Epidermidis.

Other bacteria GR (+): Bacillus anthracis, corynebacterium diphtheriae, peptococcus and peptostreptoccus.

GR ( -): Neisseria meningitidis, N. Gonorrhoeae, Haemophilus Influenzae.Other bacteria GR ( -) bacteria: Bordetella Pertussis, Brucella Abortus, Campylobacter spp., Legionella Pneumophila, Pasteurella and Vibrio spp.

pharmacokinetics

chloramphenicol is rapidly absorbed through the digestive tract, widely distributed in most body tissue and fluid, which is drained mainly in the liver due to glucuronyl transferase.

Before taking Chloramphenicol 250mg Mekophar treats severe bacterial infections caused by sensitive bacteria (10 blisters x 10 tablets)

How to use

Take oral use.

Dosage

Adults

Take 1.0 grams to 2.0 grams/day, divided into 4 times.

Children

Take 50mg/kg/day, divided into 4 times.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Treatment of symptoms after gastric lavage.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Chloramphenicol 250mg, you may experience unwanted effects (ADR).

Common: Nausea, vomiting, diarrhea, foreign rash.

Uncommon: granulocytosis, thrombocytopenia and anemia, urticaria, hypersensitivity reactions.

Rare: headache, grain leukemia, non -regenerated anemia, optic neuritis, peripheral polyauma, gray syndrome in newborns, and children under 2 weeks of age: Especially risk at high doses.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Chloramphenicol 250mg contraindications in the following cases:

Patients with hypersensitivity or toxic reactions caused by chloramphenicol.

Do not use chloramphenicol to treat common bacterial infections or as a prophylactic drug.

Caution when using

serious reactions, sometimes fatal, in patients using chloramphenicol have been notified.

Chloramphenicol must be discontinued if a grid reduction occurs, leukopenia, thrombocytopenia, anemia or other abnormal hematology are attributed to chloramphenicol.

Shortly stop chloramphenicol if a optic or peripheral neuritis occurs.

Be careful to use chloramphenicol for patients with impaired renal or liver function and decrease in the corresponding ratio.

The ability to drive and operate machinery

has not seen the drug that affects the ability to drive and operate the machine.

Pregnancy

Do not use chloramphenicol for pregnant women near the birth period or during labor because it can occur toxic effects on the fetus.

Breastfeeding period

chloramphenicol is distributed into breast milk, must be used cautiously for nursing mothers because of the toxic effects on infants and breastfeeding babies.

Drug interaction

chloramphenicol destroys the enzyme cytochrom P450 in the liver, is the enzyme responsible for the metabolism of many drugs.

chloramphenicol can affect the metabolism of chlorpropamid, dicumarol, phenytoin and tolbutamid due to inhibition of microsome enzymes and thus can last half a lifetime of plasma and increase the effects of these drugs.

Simultaneous use of chloramphenicol and phenobarbital can lead to reduced antibiotic concentration in plasma because phenobarbital causes enzyme P450 induction capable of destroying chloramphenicol.

When used simultaneously with iron, vitamin B12 or folic acid, chloramphenicol can slow down the response to these drugs.

Because rifampicin causes microsome enzymes needed for chloramphenicol metabolism, simultaneous use of these drugs can lead to decreased chloramphenicol levels in plasma. Avoid simultaneous use of chloramphenicol with drugs that can cause bone marrow impairment.

Storage

In a dry place, avoid light, temperature below 30 ° C.

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