Chloroquin Phosphate 250mg Mekophar prevents or treats acute malaria (200 tablets)

Dosage form Box of 200 tablets
Specifications Chloroquine
Ingredient Lupus erythematosa, malaria, rheumatoid arthritis

Ingredient

Composition information	Content
Chloroquine	250mg

Uses

Indications

Chloroquin phosphate 250mg is indicated in the following cases:

Prevention or treatment of acute malaria caused by P. Malariae, P. Vivax, P. Ovale and P. Falciparum sensitive to drugs.

Destruction of external amoeba.

rheumatoid arthritis, lupus erythematosus.

Pharmacokology

chloroquine phosphate has a good effect on the red blood cells of P. Vivax, P. Malariae and most P. Falciparum strains (except for gametes). The mechanism of anti -malarial effects is unknown but may be due to the drug that affects the digestive process of Haemoglobin by increasing the pH in the cyst of malaria parasite cells or hindering nucleoprotein synthesis of malaria parasites.

pharmacokinetic

chloroquine phosphate absorbs quickly and almost completely in the digestive tract. The drug is slowly eliminated but increases when the urine is acidicated, more than half of the amount of chloroquine phosphate excreted by urine in the formless form.

Before taking Chloroquin Phosphate 250mg Mekophar prevents or treats acute malaria (200 tablets)

How to use

Take the chloroquin phosphate pills 250mg with a full glass of water.

Dosage

According to the instructions of the physician.

Dose for malaria treatment:

Age

DAY 1 (PEOPLE)

DAY 2 (PEOPLE)

DAY 3 (TEACHER)

1 -

5 -

12 -

1½

≥ 15

Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Treatment: When an overdose is urgent, it is necessary to cause vomiting or gastric lavage before taking the patient to the hospital.

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using chloroquin phosphate 250mg, you may experience unwanted effects (ADR).

When using high and prolonged doses, Chloroquine Phosphate has an impact on the vision of the patient but this effect is usually gone when stopping the drug.

Other undesirable effects:

Common: headache, rash, itching, vomiting, nausea, diarrhea.

Less: anxiety, blurring, corneal disease, vision loss, ... rare: deafness, light sensitive skin, platelet reduction and neutropenia, ...

When encountering side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using chloroquin phosphate 250mg, you need to read the instructions carefully and refer to the information below.

Contraindicated

Chloroquin phosphate 250mg contraindicated in the following cases:

Hypersensitivity to compounds 4 - Aminoquinoline.

There are changes in vision, retina caused by 4– Aminoquinoline or any other reason.

Be cautious when using

If there is a severe blood disorder while being treated, it is necessary to stop the drug immediately.

Patients taking the drug for a long time need eye examination and regular tests on blood formula.

People with liver, kidney disease, or have problems with porphyrin metabolism, psoriasis, epilepsy history.

Patients with glucose -6– 6– Phosphate dehydrogenase deficiency need to monitor anemia phenomenon due to increased red blood cell destruction during medication.

Alcoholics because the drug has the ability to accumulate in the liver.

Pregnancy and lactation

is only used to prevent malaria for pregnant women when necessary.

Be cautious when used for breastfeeding women.

Drug interaction

antacids or kaolin may reduce the absorption of chloroquine phosphate, so only drink chloroquine phosphate after taking those drugs for 4 hours.

Cimetidine reduced metabolism and elimination, increasing the distribution volume of chloroquine phosphate.

Ranitidine affects the pharmacokinetics of Chloroquine Phosphate.

When using Chloroquine Phosphate with other anti -malaria drugs such as Quinine, Mefloquine, Amodiaquine, Artemisinin or Fansidar may appear antagonistic mechanism that reduces P. Falciparum in vitro.

With other antibacterial drugs:

Simultaneously used with Metronidazole can cause acute disorder.

chloroquine phosphate reduces ampicillin absorption capacity.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children.

Expiry date: 5 years from the date of manufacture.

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