Ciacca Davipharm skin gel treatment for mild to medium to medium acne skin (10g)

Dosage form Clindamycin, Adapalene
Specifications DAVI
Ingredient Vietnam

Ingredient

Thành phần cho 10g

Composition information	Content
Clindamycin	1%
Adapalene	0.1%

Uses

indications

Ciacca drugs are indicated in the following cases:

Treatment of acne -prone skin mild to moderate to moderate acne, acne and pus acne.

is an antibiotic belonging to the Lincosamid group. The effect of clindamycin is to link with the 50S sub -dividend of ribosom, thus inhibiting bacterial protein synthesis. Clindamycin has a bactericidal effect at low concentrations and bactericidal at high concentrations.

Bacterial resistance mechanism for clindamycin is methylation of RNA in the mini part of the ribosom part of bacteria, this type of resistance is often through plasmid intermediaries. There is a cross -resistance between clindamycin and erythromycin because these drugs act on the same position of bacterial ribosom.

In vitro effects of clindamycin for the following bacteria:

Gram -positive bacteria bridge

Staphylococcus aureus, Staphylococcus Epidermidis, Streptococcus (except S. Faecalis). Pneumococcus.

Anaerobic gram bacillus

bacteroides (B.fragilisi) and Fusobacterium spp.

Anaerobic gram bacillus is not born

propionibacterium, eubacterium and actinomyces spp.

Anaerobic gram -positive bacteria

peptococcus and peptostreptococcus spp., Clostridium perfringens (except C. Sportogenes and C. Tertium).

Other bacteria

chlamydia trachomatis, toxoplasma gondii, plasmodium falciparum, pneumocystis carinii, gardnerella vaginalis, mycoplasma brominn.

The following bacteria are often resistant to clindamycin

Gram -negative bacillus, Streptococcus Faecalis, Nocardia SP, Neisseria Meningitidis, Staphylococcus aureus resistant to methicillin, Haemophilus influenzae.

adapalen

is the active ingredient like retinoids with anti -inflammatory effects on Vivo and In Vitro. Adapalen is basically durable with oxygen, lighting and is not reactive. In terms of mechanism, adapalen is like tretionin associated with specialized receptors for retinoic acid in the nucleus, but unlike tretionoin is not associated with the protein receptor receptor in the cytoplasm.

Adapalen applied on the skin to treat acne on the mouse model and act on the abnormality of the keratinization and the epidermal differentiation, both of these processes are the cause of acne. The impact of Adapalen is thought to be the process of normalizing the differentiation of epithelial cell follicles, resulting in reducing the formation of acne core.

Adapalen is better than retinoid reference substances in the testing test of standard anti -inflammatory properties both on vivo and in vitro. Mechanisms, chemical inhibitors and chemicals of polygamy white blood cells and arachidonic acid lipocids into inflammatory intermediaries. This study proposes that the ingredient that causes inflammation through the cell intermediate of acne can be changed by Adapalen.

pharmacokinetic

absorption

In the study of under the skin, reaching the largest concentration Clindamycin in serum when using the gel after 4 weeks is negligible (0.043% of the dose). Absorb adapalen through the skin slowly, after applying Adapalen to the wide skin with acne for a long time in clinical trials, the adapalen concentration in plasma is not detected with analytical sensitivity of 0.15 ng/ml.

Distribution

After using Adapalen (marking C14) on mice (intravenous injection, blessing, drinking or applying skin), rabbits (intravenous injection, drinking or applying skin) and dogs (intravenous and oral), radioactive properties are detected in many tissues, the highest concentration in the liver, spleen, adrenal glands and ovaries.

Metabolism - Elimination

Animal metabolism is identified as through the reduction of methyl oxygen, hydroxy and conjugated, excreted mainly through biliary tract.

Before taking Ciacca Davipharm skin gel treatment for mild to medium to medium acne skin (10g)

How to use

Ciacca 10g medicine is used topical.

Dosage

Adults and adults (from 13 to 17 years old)

CIACCA is used for acne -prone skin after washing, used once a day before going to bed.

Apply a thin layer of gel to your fingers, away from eyes and lips. Make sure the area has been applied dry.

When using the drug regularly or alternating to treat acne, it is necessary to consult a doctor to continue maintaining the use of CIACCA for patients lasting for more than 3 months.

Patients need to reduce the degree of regular use of drugs or temporarily stop treatment that can re -use medication or continue treatment when the doctor assesses the patient may tolerate the drug.

Children

The safety and effectiveness of CIACCA has not been established in children before puberty (under 12 years old) because common acne types rarely appear in this age group.

Ciacca continuous treatment should not exceed 12 weeks.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Ciacca, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Skin: Red skin, skin peeling, dry skin. Burns, itching.

Skin: The feeling is unusual, worse than acne.

Used for a long time with CIACCA possible.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Ciacca drugs are contraindicated in case of sensitivity to any component of the drug.

Be cautious when using

When using the drug if there is a sensitive reaction or serious irritation, stop the drug immediately. If on the spot, patients should not take the drug regularly, temporarily stop, or do not continue to use anymore.

CIACCA is not exposed to the eyes, mouth, nostrils or mucous membranes. If the drug is in the eye, wash immediately with warm water.

The drug is not applied to the scratched skin, eczema.

The drug is not used for people with severe acne, the area of acne spread throughout the body, especially women of the birth age, do not use effective contraception.

To be out of reach of children.

The ability to drive and operate machinery

Based on the pharmacokinetics and clinical experience, the drug does not affect the ability to drive and operate machinery.

Pregnancy

There is no information on the effects of adapalen in pregnant women, so the drug is not used during pregnancy unless there is a doctor's review.

The drug should not be used for women of the age of childbirth unless they use effective contraception.

Breastfeeding period

CIACCA's safety in breastfeeding women has not been set. Do not recommend Ciacca treatment for nursing women.

Drug interaction

There is no knowing interaction between other preparations used on the skin at the same time as the CIACCA, but the retinoids and preparations have the same effects should not be used at the same time as adapalen.

Basically, adapalen is durable with oxygen, light and is not reactive. While the research is expanded on animals and people show that there is no toxic reaction and light sensitivity reaction when using Adapalen, the level of safety when using the drug during sun exposure or UV exposure is not set on both animal and human objects. Should avoid sun exposure or UV rays.

Adapalen absorbs through human skin slowly and thus interacting with all -body drugs that do not occur. There is no evidence of the effect of using Ciacca on the skin with the effectiveness of oral drugs such as birth control pills and antibiotics.

CIACCA can cause light irritation in place, so when used at the same time, drugs that have burns, skin abrasion, bleaching, skin astringent or irritating products (aromatic and alcohol) will increase irritation. However, acne treatments on skin (erythromycin 4%) or Clindamycin phosphate solution (1% base), 10% benzoyl peroxide gel are used in the morning. When CIACCA is used at night, it will not reduce the effect and increase the irritation.

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C.

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