Ciheptal 1200 Medisun Treatment Treatment of cognitive, dizziness (20 tubes x 10ml)

Piracetam (derivative of Gamma-butyric gamma acid, GABA) is considered a substance that has a mental effect (improving the metabolism of nerve cells), although people do not know much about its specific effects as well as its mechanism of action. Even the definition of Nootropic cave is still vague.

In general, the main effects of drugs are called Hung Tri (such as: Piracetam, Oxiracetam, Aniracetam, Etiracetam, Pramiracetam, Tenilsetam, Suloctidil, Tamitinol) are improving learning and memory ability.

Many of these substances are considered to have a stronger effect on piracetam in terms of learning and memory. It is thought that in ordinary people and in people with impaired function, Piracetam works directly to the brain to increase the activity of the brain area (the brain area is involved in the mechanism of awareness, learning, memory, alertness and consciousness).

Piracetam affects some neurotransmitters such as acetylcholin, noradrenalin, dopamin ... This can explain the positive effect of the drug on learning and improve the ability to perform memory tests.

The drug can change the neurotransmitter and contribute to improving the metabolic environment so that the nerve cells work well.

On experiments, Piracetam has a protective effect against metabolic disorders due to ischemia by increasing brain resistance to oxygen deficiency.

Piracetam increases the mobilization and use of glucose without depending on the supply of oxygen, facilitates the pentose path and maintains energy synthesis in the brain.

Piracetam enhances the recovery rate after damage due to lack of oxygen by increasing the rotation of inorganic phosphate and reducing glucose and lactic acid accumulation.

Under normal conditions as well as when oxygen deficiency, Piracetam is found to increase the amount of ATP in the brain due to increased ADP conversion to ATP; This may be a mechanism to explain some useful effects of the drug.

The impact on acetylcholin's transmission (increasing acetylcholin release) may also contribute to the mechanism of action of the drug.

The drug also works to increase dopamine release and this may have a good effect on memory formation. The drug has no effect on sleep, sedation, resuscitation, analgesic, nervous or neuron and no effect of GABA.

Piracetam reduces the ability to converge platelet and in case of abnormal erythrocytes, the drug can cause red blood cells to restore deformation and ability to pass through capillaries. The drug has anti -vibration effect.

Dynamic pharmacokinetics

Piracetam used by oral is absorbed quickly and almost completely in the digestive tract. Biology nearly 100%. The peak concentration of plasma (40 - 60 micrograms/ml) appears 30 minutes after taking a dose of 2g.

The peak concentration in the cerebrospinal fluid is achieved after taking the drug 2 - 8 hours. Absorption of drugs does not change during long -term treatment.

The distribution volume is about 0.6 liters/kg. Piracetam is soaked in all tissues and can pass through the blood - brain, each other - placenta and even the membranes used in the kidney.

High concentrations in the cerebral cortex, frontal lobe, lobes and occipital lobe, cerebellum and base kernel. Half life in plasma is 4 - 5 hours, half a life in cerebrospinal fluid about 6 - 8 hours.

Piracetam is not attached to plasma proteins and is excreted through the kidneys in the form of intact. Piracetam clearance coefficient of normal human kidneys is 86 ml/min. 30 hours after drinking, more than 95% of the drug is discharged in urine.

If kidney failure, half a lifetime elimination increases: In patients with complete renal failure and not recovering, this time is 48 - 50 hours.

do when using overdose? However, the use of an overdose may lead to some unwanted effects of the drug.

Handling: In case of overdose, symptomatic treatment, may include dialysis, and applied common supportive measures.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Can reduce the side effects of the drug by reducing the dose.

When experiencing side effects of the drug, patients need to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Be cautious when used

Because Piracetam is discharged through the kidneys, the half -life of the drug increases directly to the degree of renal failure and creatinine clearance. It is necessary to be very cautious when taking drugs for patients with renal failure, need to monitor kidney function in these patients and elderly patients.

When the clearing coefficient of creatinine is below 60 ml/minute or when the serum creatinine is over 1.25 mg/100 ml, the dose adjustment must be adjusted: