Cimetidine MKP 300mg Mekophar medicine for short -term treatment of stomach ulcer, progressive duodenum (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Cimetidine
Ingredient Gastroesophageal reflux

Ingredient

Composition information	Content
Cimetidine	300mg

Uses

Indications

Cimetidine 300 mg is indicated in the following cases:

Short-term treatment of stomach ulcers, duodenal progression. The esophagus, stomach, duodenum. The amount of pepsin produced by the stomach also decreases.

pharmacokinetics

Cimetidine is quickly absorbed by the digestive tract. Using drugs when hungry, the initial peak concentration in plasma is achieved after about 1 hour, the next peak concentration is achieved after about 3 hours. Food slows down and may reduce the absorption of the drug. Oral bioavailability of cimetidin is about 60 - 70%.

cimetidine is widely distributed in the body. The half -life is about 2 hours and lasts longer in people with renal failure. Cimetidine is partially metabolized in the liver into hydroxymethyl cimetidine and sulfoxid, about 50% of oral doses are excreted in urine in the form of unchanged after 24 hours.

Before taking Cimetidine MKP 300mg Mekophar medicine for short -term treatment of stomach ulcer, progressive duodenum (10 blisters x 10 tablets)

How to use

Should take medicine at meals and/or before going to bed. According to the doctor's instructions.

Dosage

Cimetidine dose for adults:

Stomach ulcer, duodenum: 800mg/day, take the only dose in the evening before going to bed for at least 4 weeks for duodenal ulcer and at least 6 weeks for stomach ulcers. The maintenance dose is 400mg/day.

Dosage from 20 - 30mg/kg/day, divided 3-4 times.

Dosage for children under 1 year of age: No report.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

Common signs: dilated pupils, chaos, fast circuits, agitation, disorientation, respiratory failure, ...

Processing:

Gastric lavage, vomiting and treatment of symptoms.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using cimetidine drugs, you may experience unwanted effects (ADR). Some side effects recorded in research on users of this drug are:

Common

: ADR> 1/100

Digestive: diarrhea and other digestive disorders.

Endocrine: Forgiveness when taking high doses for prolonged high doses.

Cardiovascular: Slow, fast circuit, atrial - ventricular congestion. The antihistamine H2 drugs reduce acid secretion should also reduce the absorption of vitamin B12, very easy to cause anemia. Acute.

kidney: interstitial nephritis The community is affected). Notify the doctor the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cimetidine 300mg contraindicated drugs in cases of sensitivity to cimetidine or other ingredients of the drug.

Be cautious when taking drugs

Before taking cimetidine to treat stomach ulcers, it is necessary to eliminate cancer, because when using the drug can cover the symptoms causing delayed diagnosis.

Dosage reduction in kidney failure.

Cimetidin interacts with many drugs, when used in combination with other drugs, they must be carefully considered.

The ability to drive and operate machinery

Be cautious when used for train drivers and operate the engine because the drug can cause headaches, dizziness, sleeping chicken.

Pregnancy

cimetidin passes through the placenta, does not take drugs during pregnancy. If used is necessary, consult your doctor before using to consider benefits and risks.

Breastfeeding period

cimetidin passes through breast milk, does not take medicine during breastfeeding. If used is necessary, consult your doctor before using to consider benefits and risks.

Medicinal interaction

cimetidine and other anti -H2 drugs reduce the absorption of drugs that their absorption depends on the stomach pH such as ketoconazol, otraconazole. These drugs must be taken at least 2 hours before taking cimetidin.

cimetidine may interact with many drugs, but only some clinical significance, especially with drugs with narrow therapeutic values, are at risk of toxicity, need to adjust the dose. Most of the interactions are due to the attachment of cimetidine with the isenzyme of Cytochrom P450 in the liver, especially in CYP1A2, CYP2C9, CYP2D6 and CYP3A4, leading to inhibition of oxidation in the liver microsom and increase bioavailability or plasma concentration of drugs metabolized by these enzymes.

A few other interactions are due to the competition with the excretion in the renal tubules. The mechanism of interaction such as changing blood flow through the liver only plays a secondary role.

Meaningful interactions occur with:

anti -epileptic drugs such as phenytoin, carbamazepin, valproic acid. Nifedipin, processipin, propranolol, quinidin, theophylin.

triamterene. Antacids can reduce cimetidine absorption if taken with them, should drink an hour apart.

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C.

Should read carefully storage instructions on the packaging or ask the pharmacist.

Keep pills out of reach of children and pets.

Expiry date: 36 months from the date of manufacture.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.