Cimetidine MKP 300mg Mekophar medicine for short -term treatment of stomach ulcers, progressive duodenum (100 tablets)

Dosage form Box of 100 capsules
Specifications Cimetidin
Ingredient Gastroesophageal reflux

Ingredient

Composition information	Content
Cimetidin	300mg

Uses

Indications

Cimetidin 300mg drugs are indicated in the following cases:

Short-term treatment of stomach ulcers, duodenal progression. The esophagus, stomach, duodenum. The amount of pepsin produced by the stomach also decreases.

pharmacokinetics

Cimetidine is quickly absorbed by the digestive tract. Cimetidin used when hungry, the initial peak concentration in plasma is achieved after about 1 hour, the next peak concentration is achieved after about 3 hours. Food slows down and may reduce the absorption of the drug. Oral bioavailability of cimetidine is about 60-70%.

cimetidine is widely distributed in the body. The half -life is about 2 hours and lasts longer in people with renal failure. Cimetidine is partially metabolized in the liver into hydroxymethylcimetidine and sulfoxid, about 50% of oral doses are excreted through urine in the formless form after 24 hours.

Before taking Cimetidine MKP 300mg Mekophar medicine for short -term treatment of stomach ulcers, progressive duodenum (100 tablets)

How to use

Should take medicine at meals and/or before going to bed.

Dosage

Adults

Gastric ulcer, duodenum: 800 mg/day, take the only dose in the evening before going to bed for at least 4 weeks for duodenal ulcer and at least 6 weeks for stomach ulcers. The maintenance dose is 400 mg/day.

Gastroesophageal reflux: 300 - 400 mg/time, 4 times a day, used from 4 - 8 weeks.

Zollinger -Eleson syndrome: 300 - 400 mg/time, 4 times a day.

Stress causes gastrointestinal ulcers on: 300 mg/time, repeat every 6 hours.

Children over 1 year of age

Dosage from 20 - 30 mg/kg/day, divided 3-4 times.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

Treatment: gastric lavage, vomiting and treatment of symptoms.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using cimetidin 300mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: diarrhea and other digestive disorders.

nerve: headache, dizziness, sleep, fatigue.

Skin: rash.

Endocrine: Big breast enlargement in men when treating over 1 month or high doses.

Uncommon, 1/100> ADR> 1/1000

Endocrine: Imparty when taking high doses is prolonged.

Skin: Lumpy, acne -based, urticaria.

Liver: Increase the liver enzyme temporarily, all out when stopping the drug. kidney: increased blood creatinine.

Rare, ADR

Cardiovascular: Slow circuit, fast circuit, atrial - ventricular congestion.

Blood: Multi -core leukemia, grain leukemia, platelet reduction, neutropen leukemia, all bloody hematoma, non -regenerated anemia. The antihistamine H2 drugs reduce acid secretion should also reduce the absorption of vitamin B12, very easy to cause anemia. nerve: Confused recovery (especially in the elderly and people with serious illness such as kidney failure, liver failure, brain syndrome), depression, agitation, restlessness, hallucinations, disorientation. liver: Hepatitis bile, jaundice, liver dysfunction.

Pancreatic: Acute pancreatitis. kidney: interstitial nephritis. muscle: muscle pain, joint pain.

hypersensitivity: fever, response including, anaphylaxis, stevens-johnson syndrome, poisoned epidermal necrosis.

Skin: erythema, peeling dermatitis, diverse roses, bald hair loss. Respiratory: Increased risk of bacterial infections (hospital pneumonia, caught pneumonia in the community).

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cimetidine 300 mg is contraindicated in cases of sensitivity to cimetidine or other ingredients of the drug.

Precautions when using

before using cimetidine to treat stomach ulcers must eliminate cancer likelihood, because when using the drug can cover symptoms causing delayed diagnosis.

Dosage reduction in kidney failure.

Cimetidin interacts with many drugs, when used in combination with other drugs, they must be carefully considered.

The ability to drive and operate machinery

Be cautious when used for train drivers and operate the engine because the drug can cause headaches, dizziness, sleeping chicken.

Pregnancy

cimetidin passes through the placenta. Do not take drugs during pregnancy.

Breastfeeding period

cimetidin passes through breast milk. Do not take medicine during breastfeeding.

Medicinal interaction

cimetidine and other anti -H2 drugs reduce the absorption of drugs that their absorption depends on the stomach pH such as ketoconazol, otraconazole. These drugs must be taken at least 2 hours before taking cimetidin.

cimetidine may interact with many drugs, but only some clinical significance, especially with drugs with narrow therapeutic values, are at risk of toxicity, need to adjust the dose. Most of the interactions are due to the attachment of cimetidine with the isenzyme of Cytochrom P450 in the liver, especially in CYP1A2, CYP2C9, CYP2D6 and CYP3A4, leading to inhibition of oxidation in the liver microsom and increase bioavailability or plasma concentration of drugs metabolized by these enzymes.

A few other interactions are due to the competition with the excretion in the renal tubules. The mechanism of interaction such as changing blood flow through the liver only plays a secondary role.

Meaningful interactions occur with:

anti -epileptic drugs such as phenytoin, carbamazepin, valproic acid.

Cancer treatments such as alkylation, anti -chemical drugs.

Benzodiazepin derivative.

Biguanid derivatives against diabetes like metformin.

lidocaine, metronidazol, nifedipine, processipin, process, propranolol, quinidine, theophylin.

Three -round antidepressants such as amitriptylin, nortriptylin, desipramin, doxepin, imipramin.

Opioid analgesics such as Pethidin, Morphin, Methadon. triamteren. warfarin and other oral anticoagulants such as acenocoumarol and phenindion.

zalcitabin, zolmitriptan.

to avoid coordination of cimetidine with these drugs or use caution, monitor the effects or concentrations of drugs in plasma and reduce the appropriate dose. Antacids can reduce cimetidine absorption if taken with, should drink an hour apart.

When using cimetidin, you need to be cautious if drinking.

Storage

Store in a dry place, avoid light, temperature not exceeding 30 ° C.

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