Ciprofloxacin 0.3% bidiphar treatment for infections (5ml)

Dosage form Box x 5ml
Specifications Ciprofloxacin
Ingredient Middle otitis, external otitis, keratitis

Ingredient

Composition information	Content
Ciprofloxacin	0.3%

Uses

Indications

0.3% Ciprofloxacin is indicated in the following cases:

Treatment of eye infections due to sensitive strains: keratitis, conjunctivitis.

Pharmacology

ciprofloxacin is a semi -synthetic antibiotic, wide antibacterial spectrum, belonging to the Fluoroquinolon group. The drug has the effect of killing bacteria due to inhibiting DNA Gyrase and Topoisomerase IV (are essential enzymes for the reproduction of DNA of bacteria), so the copy of Chromosom makes bacteria not reproduce quickly.

Ciprofloxacin has a stronger printing effect than nalidixic acid (non -fluorized quinolone). Ciprofloxacin also works with bacteria that have resisted antibiotics from other groups (aminoglycosides, cephalosporin, tetracyclin, penicilin ...).

Unlike the Beta Lactam antibiotics that have the strongest effect on sensitive bacteria in the fast growing stage (Log), Ciprofloxacin bactericidal at both fast and slow growing stage.

For most sensitive bacteria, the minimum concentration of bactericidal (MBC) of ciprofloxacin is 1-4 times higher than the mic; MBC is sometimes 8 times higher than the mic. At concentrations achieved in treatment, quinolones do not affect Topoisomerase Typ II in mammals, this enzyme is similar to bacteria, but different from the bacterial Gyrase DNA and does not cause supercoiling (Supercoiling).

Although clinical significance has not been determined, Ciprofloxacin has the effect of inhibiting post -antibiotics and has the effect of immune function. The effect of the drug is reduced in the acidic environment, in the urine but does not decrease in serum.

pharmacokinetics

ciprofloxacin absorbs quickly and easily in the digestive tract. When food and anti -acid drugs, the absorption of drugs is slowed but not significantly affected. After drinking, the maximum concentration of Ciprofloxacin in the blood appears after 1-2 hours with bioavailability of 70-80%.

Ciprofloxacin is widely distributed throughout the body and penetrates well into tissues, with high concentrations in places where infected areas (body fluids, tissues). The concentration in tissue is usually higher than the serum concentration, especially in parenchyma, muscle, bile and prostate. The concentration in lymph and extracellular fluid is also close to the serum concentration. The concentration of drugs in saliva, nose, sputum, abdominal fluid, skin, cartilage and bone is lower, but still at an appropriate level.

If the meninges are normal, the concentration of the medication in the cerebrospinal fluid is only 10% of plasma concentrations. But when the meninges are inflamed, the drug is more absorbed. Ciprofloxacin passes through the placenta and excreted through breast milk. In honey also has high levels of drugs.

Metabolic substances: At least 4 metabolites have been defined. Oxociprofloxaxin appears mainly in urine and sulfociprofloxacin is the main metabolite in the feces. Ciprofloxacin is excreted mainly through the urine by filtering in the glomerular and excretion in the renal tubules.

Other elimination lines account for about 1/3 are metabolic in the liver, the exit through bile and excreted through the mucosa into the intestine (this is the mechanism of clearing the compensation in patients with severe renal impairment).

Before taking Ciprofloxacin 0.3% bidiphar treatment for infections (5ml)

How to use

Use Ciprofloxacin 0.3% small eyes, small ears.

Dosage

Small eyes

Cerematitis

Day 1: 2 drops every 15 minutes for the first 6 hours, then 2 drops every 30 minutes for the rest of the day.

Monday: 2 drops every 1 hour.

Day 3 to 14: 2 drops every 4 hours. Treatment time should last from 2 weeks, or maybe up to 3 weeks if there is not a phenomenon of corneal epithelium regeneration.

conjunctivitis

The first 2 days: small 1-2 drops/2 hours.

The next 5 days: small 1-2 drops/every 4 hours.

Small ears

Put in the ears 2 - 3 drops, each use 2-3 hours apart.

lie or hold your ears for about 2 minutes so that the drug does not flow out.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

There is no study on the use of Ciprofloxacin 0.3% overdose.

Handling

If any abnormal expression occurs when overdose, immediately notify the doctor or take the patient to the nearest medical center for proper treatment.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Ciprofloxacin 0.3%, you may experience unwanted effects (ADR).

Very common, ADR> 1/10

Eyes: burning, uncomfortable in the eyes.

Common, ADR> 1/100

Eyes: scales of eyelashes, feeling strange in the eyes, itching, conjunctiva.

Uncommon, 1/1000

Eyes: edema, corneal inflammation, watery eyes, lower vision, corneal dyeing.

Instructions on how to handle ADR

When experiencing side effects of 0.3%Ciprofloxacin, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Ciprofloxacin 0.3% contraindicated in the following cases:

Hypersensitivity to ciprofloxacin or ingredients of the drug.

Having a history of hypersensitivity to quinolons.

Be cautious when using

carefully when using Ciprofloxacin for prolonged because it can increase the proliferation of irreversible bacteria causing superinfection.

Do not wear contact lenses when used.

The ability to drive and operate machinery

During the use of the drug, the patient may experience blurred vision, vision loss, itchy eye or other eye disorders. Be careful when using the drug for this object. When you are blurred, you must wait until you see it clearly before you can continue to work.

Pregnancy

There are currently no good and adequate control studies when taking drugs for pregnant women. The drug should only be used only when the benefits outstanding risks may occur. Consult your doctor before use.

The period of breastfeeding

There has been no report on harmful reactions on infants or young children when taking medicine for breastfeeding mothers. Be careful when using the drug for this object. Should consult your doctor before use.

Drug interaction

Currently, there is no specific report on the interaction between Ciprofloxacin 0.3% and other drugs. Therefore, before and during the use of the drug, contact the doctor and provide information about the drugs being used for the most reasonable medication advice.

Storage

Store in a dry place, avoid light, the temperature does not exceed 30 ° C. Do not take the drug that has opened the lid for more than 15 days.

To be out of reach of children and pets in the house.

Other drugs

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