Ciprofloxacin 250-US oral powder treated up and down urinary tract infections, gonorrhea (10 packs)

Dosage form 10 package box
Specifications Ciprofloxacin
Ingredient US Pharma USA Joint Stock Company

Ingredient

Composition information	Content
Ciprofloxacin	250mg

Uses

Indications

Ciprofloxacin is indicated in the following cases:

Upper and lower urinary tract infections, gonorrhea, prostatitis, osteoporosis - myelitis, severe bacterial bacterial inflammation, blood infection, immunodeficiency. Ciprofloxacin works well with antibiotic -resistant bacteria of other groups (aminoglycosides, cephalosporin, tetracyclin, penicillin ...) and is considered one of the most powerful drugs in the fluoroquinolone group.

antibacterial spectrum

Ciprofloxacin has a very wide antibacterial spectrum, including most important pathogens. Most gram -negative bacteria, including pseudomonas and enterobacter are sensitive to the drug. Gram -positive bacteria (Enterococcus strains, Staphylococcus, Streptococcus, Listeria monocytogenes ...) are less sensitive. Ciprofloxacin does not work on most anaerobic bacteria. Bacteria that cause intestinal diseases such as Salmonella, Shigella, Yersinia and Vibrio Cholerae are often highly sensitive. The bacteria that cause respiratory diseases such as Haemophilus and Legionella are often sensitive, Mycoplasma and Chlamydia are only sensitive to the drug, Neisseria is often very sensitive to the drug.

pharmacokinetic

absorption

Ciprofloxacin absorbs quickly and easily in the digestive tract. When food and anti -acid drugs, the absorption of drugs is slower but not significantly affected. After drinking, the maximum concentration of Ciprofloxacin in the blood appears after 1-2 hours with absolute biological available 70-80%. Maximum maximum concentration in serum corresponding to 500mg doses is 2.4mg/l.

Distribution

The distribution of ciprofloxacin is very large (2 - 3l/kg body weight). The drug is widely distributed and has high concentrations in places where infections (body fluids, tissues). The concentration in tissue is usually higher than the serum concentration, especially in parenchyma, muscle, bile and prostate. Ciprofloxacin passes through the placenta and excreted through breast milk.

Metabolism

Semi -selling time in plasma is about 3.5 to 4.5 hours in patients with normal kidney function, this time is longer in patients with kidney failure and in the elderly.

Elimination

about 40 - 50% of oral dose is eliminated in the form of unchanged urine by filtering in the glomerular filter and excreted in the renal tubules. Other elimination lines are metabolic in the liver, excreted bile and excreted through the mucosa into the intestine (this is a mechanism of clearing the compensation in patients with severe kidney failure). The drug is excreted within 24 hours.

Before taking Ciprofloxacin 250-US oral powder treated up and down urinary tract infections, gonorrhea (10 packs)

How to use

ciprofloxacin 250 - USP used oral, patients should take medicine for 2 hours after meals, should take plenty of water and do not take stomach anti -acidity for 2 hours after taking the drug.

Dosage

Children and adolescents

Take 7.5 - 15mg/kg/day, divide 2-3 times.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Need to monitor patients carefully and support timely support.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Ciprofloxacin, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: Nausea, vomiting, diarrhea, abdominal pain.

Metabolism: temporarily increase the concentration of transaminase.

Uncommon, 1/1000

Body: headache, drug fever.

Blood: Eosin hypernagus, lymphocytes, polygon leukopenia, anemia, thrombocytopenia. cardiovascular: tachycardia.

Central nerve: agitation. digestive: digestive disorders. skin: rash, itching, shallow veins.

Metabolic: temporarily increased creatinine, bilirubin and alkaline phosphatase in the blood.

Muscle muscle: Pain in joints, swelling of joints.

Rare, 1/10000

Body: Anaphylaxis or anaphylaxis.

blood: hemolytic anemia, leukemia, thrombocytopenia, change of prothrombin concentration.

Central nerve: convulsions, confusion, mental disorders, paranoia, insomnia, depression, peripheral sympathetic disorders, visual disorders including hallucinations, hearing disorders, tinnitus, taste disorders and olfactory, increased intracranial pressure. digestion: fake colitis. Skin: Skin syndrome - mucosa, vasculitis, Lyell syndrome, skin erythematosus, skin redness. liver: There have been reports on some cases of liver necrosis, hepatitis, and jaundice.

muscle: muscle pain, tendonitis (heel tendon) and surrounding tissue. There are several cases of tendon broken, especially in the elderly when used in combination with corticosteroids.

Urinary - genital: There is an urinary crystal when alkaline urine, bleeding, acute kidney failure, interstitial nephritis.

Other: sensitive to light when exposed to sun, laryngeal edema or pulmonary edema, shortness of breath, bronchial spasm.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Ciprofloxacin contraindicated drug in the following cases:

People with a history of hypersensitivity to ciprofloxacin, related drugs such as nalidixic acid and other quinolones.

Do not use ciprofloxacin for pregnant women and lactation period, unless the benefits are greater than the risk of the drug.

Precautions when using

Caution should be used when using ciprofloxacin for people with a history of epilepsy or central nervous system disorders, people with liver function or kidney function, people with glucose deficiency - 6 - phosphate dehydrogenase, people with muscle weakness.The long -term use of ciprofloxacin can cause non -sensitive bacteria to overdue drugs. It is necessary to monitor patients and make antibiotics regularly to take appropriate treatments according to antibiotics.

Ciprofloxacin may cause mycobacterium tuberculosis tests to be negative.

Restricting the use of ciprofloxacin for young and old children (under 18 years old) because of the experiment, the drug has cartilage in gravity joints.

The ability to drive and operate machinery

ciprofloxacin can cause dizziness, whirling mind, affecting vehicles or operating machinery.

Pregnancy

should only use Ciprofloxacin for pregnant women in cases of severe bacterial infections without other antibiotics instead, forced to use ciprofloxacin.

Breastfeeding period

Do not use ciprofloxacin for nursing mothers, because ciprofloxacin accumulates in milk and can reach the concentration that can cause harm to children. If the mother is forced to use ciprofloxacin, they must stop breastfeeding.

Medicinal interaction

Concomitance nonsteroidal anti -inflammatory drugs (ibuprofen, indomethacin ...) will increase the side effects of ciprofloxacin.

Concomitance anti -acid drugs with aluminum and magnesium will reduce serum levels and reduce bioavailability of ciprofloxacin.

Iron products (Fumarat, Gluconate, Sulfate) significantly reduce the absorption of ciprofloxacin in the intestine. Zinc preparations have less effects.

Take the sucralfate at the same time will reduce the absorption of ciprofloxacin significantly. Antibiotics should be given 2 - 6 hours before taking sucralfat.

Ciprofloxacin absorption may be reduced half if used simultaneously some cyclophosphamide, vincistin, doxorubicin, cytosin arabinosid, mitozantron).

If using the Convidinosin simultaneously, the concentration of ciprofloxacin is significantly reduced. Ciprofloxacin should be taken before using Didanosin for 2 hours or after using Didanosin 6 hours.

Take Ciprofloxacin simultaneously with theophylin may increase the concentration of theophylin in serum, causing the side effects of theophylin. The chest of theophylin concentration in the blood and the canophylin can be reduced if it is forced to take 2 drugs.

ciprofloxacin and cyclosporin use simultaneously can cause temporary increase in serum creatinine. Should check blood creatinine twice a week.

Probenecid reduces glomerular filtration level and reduces the excretion in the renal tubules, thus reducing the elimination of drugs through urine.

warfarin in combination with ciprofloxacin can cause prothrombin. Need to regularly check blood prothrombin and adjust the dose of anticoagulants.

Storage

Store the drug in a dry place, temperatures below 30 ° C, avoiding light. Leave the medicine out of reach of children.

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