Ciprofloxacin Kabi 200mg Fresenius Kabi Treatment of infections, urinary tract infections (100ml)

Dosage form Bottle
Specifications Ciprofloxacin
Ingredient Fresenius Kabi Vietnam Joint Stock Company

Ingredient

Thành phần cho 100ml

Composition information	Content
Ciprofloxacin	200mg

Uses

Indications

Ciprofloxacin Kabin is indicated in the following cases:

Infections caused by bacteria sensitive to ciprofloxacin. Upper and lower urinary tract infections; Prostatitis; Bone inflammation; Severe bacterial intestinal inflammation, severe infections in hospitals, immunodeficiency infections. Due to the inhibition of the enzyme DNA Girase, the drug prevents the copy of chromosome, causing bacteria not to reproduce quickly. Ciprofloxacin has a good effect on antibiotic bacteria from other groups (aminoglycosides, cephalosporin, tetracyclin, penicillin ...) and is considered one of the most powerful drugs in the Fluoroquinilon group.

Antibacterial spectrum: Among the Gram (-) aerobic bacteria, Ciprofloxacin can be in vitro effects with Enterobacferiaceae, including Escherichia Coli and Citrobacter, Entobacter, Klebsiella, Proteus, Providencia, Salmonella, Sernella, Shigella, and Yersinia. This drug also shows the activity with Pseudomonas Aeruginosa and Neisseria Gonorrhoeae. H. Influenza, Moraxella Catarhalis (Branhamella Catnrhalis), and N. Meningiftidis are also sensitive strains. Other aerobic Gram (-) bacteria are reported as sensitive to Ciprofloxacin including Gardnerrella Vaginalis, Helicobacter Pylori, Legionella.

Among the aerobic gram (+) bacteria, Ciprofloxacin works with staphylococci, including penicillinase strains and non -penicillinase strains, and some staphylococcus aureus aerus antacisillin (MRSA). Streptococci, especially Streptococcus Pneumonia and Enterococci, less sensitive to Ciprofloxacin. Other gram (+) bacteria are sensitive to ciprofloxacin in vitro are Bacillus strains; With the corynebacterium strains, the activity may change.

Most anaerobic bacteria are resistant to ciprofloxacin, including bacteroides fragilis and Clostridium difficile.

Ciprofloxacin also works with Mycobacteria, Mycoplasma, Rickettsia, Chlamydia Trachomatis, and Ureaplasma Urealyticum.

Modified immunity: anti -drug strains, especially MRSA, PS strains. Aeruginosa, E. Coli, Klebsiella Pneumonia, C.jejuni, N. Gonorrhoeae, and Str. Pneumonia has appeared during treatment with ciprofloxacin, although resistant types vary depending on geography. The resistance to ciprofloxacin is mainly through chromosome intermediaries, although there is also an resistance through plasma intermediaries.

Dynamic pharmacokinetics

ciprofloxacin absorbs fast, maximum concentration in plasma after intravenous infusion for 30 minutes at a dose of 200mg is 3-4 mg/liter. Half life in plasma is about 3.5 to 4.5 hours. The drug is widely distributed, easy to penetrate into the tissue. Ciprofloxacin passes through the placenta and excreted through breast milk. Elimination in the form of unchanged urine (75%) and fertilizer (15%).

Before taking Ciprofloxacin Kabi 200mg Fresenius Kabi Treatment of infections, urinary tract infections (100ml)

How to use

intravenous infusion.

Dosage

Adults: Venous time in 60 minutes:

Intractive urinary tract infections: 200mg-400mg/ time x 2 times/ day. Time/day.

Venous time from 30-60 minutes

For patients with renal failure: Ciprofloxacin should be reduced for patients with adult kidney failure by reducing the total daily dose and/or by increasing the distance between doses depending on the patient's creatinine (CC) clearance.

Creatinine clearance (ml/minute) Dosage (intravenous transmission) Suggestions Now Patients with hemolysis or abdominal dispenser up to 400 mg every 24 hours, after the divergence

Ciprofloxacin treatment time depends on the type of infection and the severity of the disease and should be determined according to the clinical response and microorganisms of the patient. For most infections, the treatment should continue at least 48 hours after the patient has no symptoms. The treatment time is usually 1-3 weeks, but with severe or complicated bacterial infections, it may be necessary to treat longer. Ciprofloxacin treatment may need to continue for 4-6 weeks or longer in bone and joint infections. Bacterial diarrhea is usually treated for 3-7 days or may be shorter.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose?

In case of large overdose, in addition to conventional emergency measures, renal function should be monitored, including urine pH and acidification if needed, to prevent urinary crystals. Patients should be compensated enough water and in case the kidneys are damaged by urinary minorities for too long, may need hemolysis.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using the drug often has unwanted effects (ADR) such as:

Common (ADR> 1/100):

Digestive: Nausea, vomiting, diarrhea, abdominal pain.

Systemic: headache, drug fever. chemical.

Skin: rash, itching, shallow veins

Systemic body: Anaphylaxis or anaphylaxis. Increased intracranial pressure. Skin. There are a few cases of tendon broken, especially in the elderly when used in combination with corticosteroids.

To avoid the crystal, maintain enough drinking water, avoid making the urine too alkaline.

If severe and prolonged diarrhea during and after treatment, the patient may have suffered from severe disorders in the intestine (fake colitis) need to stop ciprofloxacin and replace it with another appropriate antibiotic (eg vancomycin)

If there is any sign of side effects, it is necessary to stop using ciprofloxacin and patients need to be treated at a medical facility, although these side effects are usually mild or moderate and will stop when stopping ciprofloxacin.

Notify the physician with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Ciprofloxacin drug contraindicated in the following cases:

People with a history of hypersensitivity to ciprofloxacin and related drugs such as nalidixic acid and other quinolones. Do not use ciprofloxacin for pregnant women and nursing periods, unless forced to use.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

People with a history of epilepsy or central nervous system disorders, liver failure or kidney function, G6DP deficiency, myasthenia gravis. It is necessary to monitor patients and make antibiotics regularly to take appropriate treatments according to antibiotics. Use ciprofloxacin for young and old children (on experiments, drugs that cause cartilage degeneration in gravity joints).

The effect of the drug on the ability to drive and operate machinery

The drug can cause dizziness, whirling mind, affecting vehicles or operating machinery.

Use drugs for women during pregnancy and lactation

pregnancy:

Used in cases of severe infections without other antibiotics instead.

breastfeeding period:

Do not use ciprofloxacin for nursing mothers. If the mother is forced to use ciprofloxacin, they must stop breastfeeding.

Follow the instructions from the doctor. The drug should only be used when the benefits are out of risks.

Medicinal interaction 2>

fluoroquinolon, including ciprofloxacin inhibits the cytochrome P450 CYP1A2 enzyme system and may increase the serum concentration of transformed drugs through this enzyme system such as clozapine, ropinirol, theophyline, and tizanidine. Convincidation against Ciprofloxacin and tizanidin simultaneously, when used simultaneously with theophylin must reduce theophylin dose and control serum concentration. Clozapin or Ropinizol may be used simultaneously with ciprofloxacin but must monitor clinical manifestations attached to the dose adjustment if necessary.

Ciprofloxacin has been reported to increase the effect of drug treatment for oral glibenclamid. Hypoglycemia, sometimes death occurs in patients using simultaneously with glibenclamid. Ciprofloxacin can inhibit the excretion in the renal tubules and increase the toxicity of methotrexate.

Some fluoroquinolones are able to extend the QT and therefore avoid for patients who are using rhythmic drugs such as Quinidine, Procainamide or Amiodaron and Sotalol. In addition, be cautious when used simultaneously with other drugs also have this effect (such as antihistamine Astemizol and Terfenadin, Cisapride, Erythromycin, Pentamidin, Phenothiazine or 3 -ring anti -depression drugs).

Concentric use of nonsteroidal anti -inflammatory drugs (ibuprofen, indomethacin ...) will increase the side effects of ciprofloxacin.

Ciprofloxacin absorption may be reduced by 1⁄2 if used simultaneously some cyclophosphamide, vincistin, doxorubicin, cytosine, arabinoside, mitozantron).

ciprofloxacin and ciclosporin use simultaneously can cause temporary increased serum creatinine. Should check the serum creatinine twice a week.

Probenecid reduces glomerular filtration level and reduces the excretion in the renal tubules, thus reducing the elimination of drugs through urine.

warfarin in combination with ciprofloxacin can cause prothrombin. Need to regularly check blood prothrombin and adjust the dose of anticoagulants.

Storage

Leave a cool place, avoid light, temperature below 30⁰C, avoid freezing.

To be out of reach of children, read the instructions carefully before use.

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