CKDCIPOL-N 25mg Suheung Prevented Elimination In Tibet (10 blisters x 5 tablets)

endogenous dug dug:

Special is used in organs and tissues to prevent the type of transplant after transplantation of bone marrow, kidney, liver, pancreatic, heart and heart - lung, and to prevent disease due to the recipient ("anti -object disease").The effect of cyclosporin is due to specific inhibition and restoration of immune lymphocytes in phase G0 and G1 of lymphocytes.

Priority T lymphocytes are inhibited. T cells - support are the main goals, although T -inhibited cells can also be damaged.

Cyclosporin also inhibits the production and release of lymphokin including Interleukin -2.

There is no effect on phagocytic function (changes in enzyme secretion, moving dynamic leukocytes, moving macrophages, clearing Vivo carbon in the model of animal. Cyclosporin does not inhibit bone marrow in the animal and human model.

Dynamic pharmacokinetics

Cyclosporin taken in the form of conventional cells, absorbed slowly and not completely with bio -canbisions 20-50%. Biology of micro emulsion form.

Peak concentration in plasma reaches 1.3-4 hours after drinking. Meals are high in fat significantly slowing cyclosporin absorption in conventional cell format, but does not slow down the absorption in the form of micro emulsion.

Cyclosporin has a relatively large distribution of apparent distribution (13 liters/kg). In the whole blood. 50 - 60% of cyclosporin accumulated in red blood cells; 10 - 20% of the total amount of drugs in the circulation combined with leukocyte; The rest combined with plasma protein.

Half life eliminates about 6 hours.

Cyclosporin is specialized in the liver, for more than 30 specialized products.

cyclosporin and metabolites are excreted mainly through the bile into the feces; About 6% are excreted in urine.

Dosage in case of endogenous uveitis:

What to do when overdose?

Symptoms:

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

rarely, 1/1 000

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Only use ciclosporin under the supervision of physicians with experience in immunodeficiency.

The treatment at the beginning or when there is a major change in ciclosporin therapy, it must be done in a hospital equipped with adequate testing and resuscitation.

Although ciclosporin is used in combination with corticosteroids, ciclosporin should not be used simultaneously with other immunodeficiency drugs because of the increased risk of lymphatic infection and the risk of lymphoma.

Due to the risk of anaphylaxis, only ciclosporin intravenous infusion for patients without tolerance of oral drugs. Must monitor the kidneys that manifest allergies in people with ciclosporin intravenous infusion.

When ciclosporin intravenous infusion, respiratory help, other resuscitation measures and drugs for anti -sense.

When necessary (for example, when the ability to absorb oral medication changes), adjust the dose to avoid poisoning due to high concentration of drugs in the blood or plasma, or prevent the discharging of a pieces that may occur due to low drug concentration.

Monitoring of ciclosporin concentrations in blood or plasma is especially important in people with liver transplants, because the absorption of drugs in these people can be erratic.

The ability to drive and operate machinery

People who often drive or operate machinery should use CKDCIPOL-N 25mg?

There is no research data on the effects of drugs on driving and operating machinery.

Women during pregnancy and lactation

Women during pregnancy should use CKDCIPOL-N 25mg?

ciclosporin through the placenta.

There is no full research and good verification of ciclosporin for pregnant women.

Only use ciclosporin during pregnancy when the expected benefits are more likely to occur with the fetus.

Should breastfeeding women take ckdcipol-n 25mg?

ciclosporin is distributed in milk.

Because it can have a serious disadvantage for breastfeeding, avoiding breastfeeding when the mother is using ciclosporin.

Drug interaction

drug interactions may affect the activity of the drug or cause side effects. Should notify the doctor or pharmacist a list of drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Ciclosporin concentration in biological fluid may change due to drugs or food (for example, grapefruit juice) on cytochrom P450 3A (CYP 3A) in the liver.

Medicines that reduce ciclosporin levels include carbamazepin, phenobarbital, phenytoin, rifampin, isoniazid.

Increasing ciclosporin levels include azithromycin, clarithromycin, diltiazem, erythromycin, fluconazole, otraconazole, ketoconazole, nicardipine, verapamil.

The drug increases the toxic effect of Ciclosporin's kidneys, aminoglycosides, amphotericin B, acyclovir. Simultaneous use of ciclosporin and lovastatin can lead to unwanted effects including muscle inflammation, muscle pain, muscle destruction, acute kidney failure. Simultaneous use with nifedipine increases the risk of increased productivity. Concomitance with other immunosuppressive drugs increases the risk of lymphoma and infection.