Clabact 500 DHG medicine for infections (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Clarithromycin
Ingredient Tonsillitis, pharyngitis, otitis media, sinusitis, urinary tract infections, skin infections and soft tissue

Ingredient

Composition information	Content
Clarithromycin	500mg

Uses

indications

Clabact 500 drugs are indicated in the following cases:

Used instead of penicillin in patients allergies to this drug in the treatment of bacterial infections.

Treatment of skin infections and soft tissue mild to medium. Association. This structure change has helped Clarithromycin increase oil body, expand antibacterial spectrum, increase tissue concentration, improve stability in acidic environments, increase bioavailability and reduce side effects on the digestive system.

Clarithromycin has an antibacterial effect due to a specific location on the subunit of 50S ribosome units of sensitive bacteria, thereby inhibiting bacterial protein synthesis. The minimum inhibitory concentration (mic) of clarithromycin is 2-4 times lower than the mic of erythromycin. Clarithromycin's 14-hydroxy metabolites after drinking also have antibacterial activity with stronger effects on Haemophilus influenzae.

Clarithromycin is highly effective against Gram -positive and gram -negative bacteria, aerobic and anaerobic. Clarithromycin has a strong effect on: Chlamydia Trachomatis, Ureaplasma Urealyticum, Toxoplasma Gondii, Mycobacterium Avium, Mycobacterium Leprae, Mycobacterium Kansasii, Mycobacterium chelonae, mycobacterium Fortuitum, mycobacterium Intracellulare and stronger than other macrolides for mycobacterium avium intracellular (mai = mycobacterium avium intracellulaire).

Pharmacokinetics

absorption

Clarithromycin is absorbed quickly and well through the gastrointestinal tract after drinking. Food and acidic environment in the stomach do not affect the bioavailability of clarithromycin. The peak concentration of Clarithromycin and the main metabolite 14-hydroxy clarithromycin is about 0.6-0.7 mcg/ml after taking a single dose 250 mg.

Metabolism - except for

Metabolic drugs are high in the liver and release stool through biliary tract. A significant part is discharged through urine. Clarithromycin waste time is about 3-4 hours when the patient takes 250 mg Clarithromycin, 2 times/day and about 5-7 hours when the patient takes the dose of 500 mg, 2 times/day. The selling time is prolonged in people with renal failure.

Before taking Clabact 500 DHG medicine for infections (2 blisters x 10 tablets)

How to use

Drugs for oral, orally or after meals.

Dosage

The treatment time depends on the type of infection and the severity of the disease and usually lasts 7-14 days.

Adults

Infection of the respiratory tract, skin, soft tissue: Normal doses: 250 mg x 2 times/day. In case of severe infections: 500 mg x 2 times/day. Should be reduced by half of the total dose of treatment and the drug time no more than 14 days.

Children

The usual dose: 7.5 mg/kg body weight, 2 times/day to up to 500 mg, 2 times/day.

Community pneumonia: 15 mg/kg body weight, every 12 hours. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

No information.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Clabact 500, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: digestive disorders, fake colitis.

Hypersensitivity reactions: itching, urticaria, skin rash, irritation. allergic reactions: levels of resistance from urticaria to anaphylaxis, Stevens - Johnson syndrome.

Uncommon, 1/1000

Digestive: Nausea, vomiting, abdominal pain.

Other ADR: rash, eosinophilia loves eOSIN.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Clabact 500 drug contraindicated in the following cases:

sensitive to macrolide.

Absolute contraindications with terfenadine, especially in the case of heart disease such as arrhythmia, slow rhythm, prolonged QT interval, local myocardial anemia or electrolyte imbalance.

Be cautious when using

Caution when used for people with impaired renal and liver function.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

during pregnancy, only clarithromycin is used when necessary and carefully monitored.

Lactation period

During breastfeeding, only clarithromycin when essential and carefully monitored.

Drug interaction

Clarithromycin inhibits the metabolism of carbamazepine and phenytoin increases their side effects.

Clarithromycin inhibits the metabolism of cisapride, resulting in prolonged QT interval, torsion, ventricular vibration.

Clarithromycin inhibits metabolism in theophylline's liver and increases theophylline level in plasma.

Clarithromycin reduces zidovudine's absorption.

Clarithromycin and other macrolide antibiotics affect the metabolism of terfenadine, resulting in an increase in the accumulation of this drug.

Storage

Store in a dry place, avoid light, temperature below 30 ° C.

Other drugs

Disclaimer

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