Claminat 1g Imexpharm Treatment Treatment (2 blisters x 7 tablets)

Dosage form Box of 2 blisters x 7 tablets
Specifications Amoxicillin, clavulanic acid
Ingredient Tonsillitis, pharyngitis, otitis media, sinusitis, urinary tract infections, acute bronchitis, chronic bronchitis, pneumonia

Ingredient

Composition information	Content
Amoxicillin	875mg
Clavulanic Acid	125mg

Uses

Indications

Claminat drugs are indicated in the following cases:

Infection of Ear Nose and throat: Tonsillitis, sinusitis, Middle otitis. Cellitis Wide bactericidal spectrum for many gram -positive and gram -negative bacteria due to the synthesis of bacterial cell walls. Amoxicillin is easily destroyed by B - lactamase, so it does not work for bacterial strains producing these enzymes (multiple strains of Entobacteriaceae and Haemophilus Influenzae).

Clavulanic acid produced by the fermentation of Streptomyces Clavuligerus, with B - lactam structure similar to penicilin nucleus, inhibited B - lactamase due to the majority of Gram -negative and staphylococcus bacteria born.

Clavulanic acid helps amoxicillin not B -lactamase, and expands the antibacterial spectrum of amoxicillin effectively to many common bacteria that have resisted amoxicillin, resistant penicillins and cephalosporins. Amoxicillin and clavulanic acid are bactericidal.

The antibacterial spectrum of the drug includes:

Gram -positive bacteria:

Aerobic type: Streptococcus Faecalis, Streptococcus Pneumoniae, Streptococcus Pyogenes, Streptococcus Viridans, Staphylococcus aureus, Corynebacterium, Bacillus anthracis, Listeria monocytogenes. Clostridium, peptococcus, peptostreptoccus.

Gram -negative bacteria:

Aerobic type: Haemophilus Influenzae, Moraxella Catnrhalis, Escherichia Coli, Proteus Mirabilis, Proteus vulgaris, Klebsiella, Salmonella, Shigella, Bordetella, Neisseria Gonorrhoeae, Neisseria Meningitides, Neisseria Cholerae, Pasteurella Multocida.

Amoxicillin and clavulanic acid are easily absorbed by oral. The concentration of these 2 substances in the serum is maximum after 1-2 hours of taking the drug. The absorption of the drug is not affected by food and it is best to drink right before the meal. Amoxicillin's oral bioactivity is 90% and of Clavulanic acid is 75%.

Distribution

The ability to bond with low plasma proteins, amoxicillin is 18%, 25%clavulanic acid. Amoxicillin is distributed into most tissues and fluids in the body except for the brain and spinal cord.

Metabolism

Amoxicillin is partially metabolized. The metabolism of clavulanic acid has not been determined.

Elimination

Amoxicillin waste time in serum is 1-2 hours and of clavulanic acid is about 1 hour. About 55 - 73% amoxicillin and 30-40% Clavulanic acid are discharged through urine in the form of activity.

Before taking Claminat 1g Imexpharm Treatment Treatment (2 blisters x 7 tablets)

How to use

Take medicine at the beginning of eating to minimize the phenomenon of non -intolerance in the stomach - intestines.

Do not take the drug for more than 14 days without checking the treatment.

Dosage

used in severe infections.

Adults and children weigh over 40 kg: 1 capsule 2 times/day.

Children weigh less than 40 kg: Do not use 1g claminat.

Patients with renal failure: Claminat 1 g is only used in patients with creatinine clearance greater than 30 ml/minute with unchanged dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? The acute reactions occur depending on the hypersensitivity of each individual. The risk is definitely hyperkalemia when taking a very high dose because clavulanic acid is used in the form of potassium salt. Symptoms during overdose: abdominal pain, vomiting, diarrhea. A small number of patients with rash, excitement or drowsiness.

Management:

Stop taking medicine immediately. Symptomatic treatment and support if needed.

If an overdose occurs early and there is no contraindication, can cause vomiting or gastric lavage. Hypertension can occur even in people with kidney function.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Claminat, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: diarrhea, nausea, vomiting.

Skin: itching.

Uncommon, 1/1000

Hematology: Nothing hypernagus.

DA: rash. honey: Hepatitis and jaundice, increased transaminase.

Rare, 1/10000

Anaphylaxis, leukopenia, hemolytic anemia, fake colitis, Stevens syndrome - Johnson, interstitial nephritis.

Instructions on how to handle ADR

Allergic: If there are allergic reactions, amoxicillin therapy must be stopped and immediately emergency with adrenalin, oxygen breathing, intravenous corticosteroids and ventilation, including endotracheal placement and never being treated with penicillin or cephalosporin.

fake colitis:

Mild: Stop drugs.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

CLAMINAT CLAMINAT in the following cases:

Hypersensitivity to the ingredients of the drug or antibiotics group penicillin, cephalosporin.

History of jaundice. liver failure.

Patients with renal failure with clearance

Precautions when using

Caution for patients treated with anticoagulants (warfarin) due to drugs that cause bleeding time and coagulation. However, these symptoms are often recovered and will end after 6 weeks of stopping treatment. There has been an erythema (diverse) rash that comes with lymphadenopathy fever (mononucleosis) in patients using amoxicillin. Drugs should be avoided if suspected to have a monomer hyperlemen.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

There is little experience in using preparations for pregnant women, so it is necessary to avoid using drugs in pregnant women, especially in the first 3 months of pregnancy, except for the necessary cases prescribed by a physician.

Breastfeeding period

During breastfeeding can use preparations. A small amount of drugs can be diffused into breast milk, causing hypersensitivity to children. Should consider when using this object. Notify the doctor if the patient is breastfeeding.

Medicinal interaction

The drug can cause prolonged bleeding and coagulation time.

Nifedipine increases amoxicillin absorption.

Amoxicillin reduces methotrexate secretion, increases toxicity on the gastrointestinal tract and hematoma.

Storage

less than 30 ° C, avoid moisture and light.

Other drugs

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