Claminat medicine 500mg/125mg Imexpharm for infection treatment (12 packs x 1.5g)

Dosage form 12 package box
Specifications Amoxicillin, clavulanic acid
Ingredient Tonsillitis, otitis media, sinusitis, urinary tract infections, skin infections and soft tissue

Ingredient

Composition information	Content
Amoxicillin	500mg
Clavulanic Acid	125mg

Uses

Indications

Claminat drugs are indicated for use in cases of bacterial infection treatment due to the following sensitive bacterial strains:

Infection of the Ear Nose: Tonsillitis, sinusitis, otitis media. Cell tissue. Gram -positive and gram -negative bacteria due to synthetic inhibition of bacterial cell walls. Amoxicillin is easily destroyed by B - lactamase, so it does not work for bacterial strains producing these enzymes (multiple strains of Entobacteriaceae and Haemophilus Influenzae).

Clavulanic acid produced by the fermentation of Streptomyces Clavuligerus, with B - lactam structure similar to penicilin nucleus, inhibited B - lactamase due to the majority of Gram -negative and staphylococcus bacteria born.

Clavulanic acid helps amoxicillin not B -lactamase, and expands the antibacterial spectrum of amoxicillin effectively to many common bacteria that have resisted amoxicillin, resistant penicillins and cephalosporins. Amoxicillin and clavulanic acid are bactericidal.

The antibacterial spectrum of the drug includes:

Gram -positive bacteria:

Aerobic type: Streptococcus Faecalis, Streptococcus Pneumoniae, Streptococcus Pyogenes, Streptococcus Viridans, Staphylococcus aureus, Corynebacterium, Bacillus anthracis, Listeria monocytogenes. Clostridium, peptococcus, peptostreptoccus.

Gram -negative bacteria:

Aerobic type: Haemophilus Influenzae, Moraxella Catnrhalis, Escherichia Coli, Proteus Mirabilis, Proteus vulgaris, Klebsiella, Salmonella, Shigella, Bordetella, Neisseria Gonorrhoeae, Neisseria Meningitides, Neisseria Cholerae, Pasteurella Multocida. The concentration of these 2 substances in the serum is maximum after 1-2 hours of taking the drug. The absorption of the drug is not affected by food and it is best to drink right before meals. The oral bioactivity of amoxicillin is 90% and of Clavulanic acid is 75%. Amoxicillin waste time in serum is 1-2 hours and of Clavulanic acid is about 1 hour. About 55 - 70% amoxicillin and 30-40% Clavulanic acid are discharged through urine in the form of activity.

Before taking Claminat medicine 500mg/125mg Imexpharm for infection treatment (12 packs x 1.5g)

How to use

Packaging nuggets using oral phase. Mix the powder in the water before drinking.

Should take medicine at the beginning of eating to minimize the phenomenon of non -tolerated drugs in the stomach - intestines.

Do not use drugs for more than 14 days without checking, reviewing the treatment.

Dosage

Dosage is indicated according to amoxicillin content in combination drugs.

adults and children over 40 kg:

In case of severe infections and respiratory infections: 01 pack x 3 times/day for 05 days.

Patients with renal impairment adjust the dose depending on the clearinine clearance:

Creatinin clearance> 30 ml/minute: No dose adjustment. Usually 48 hours/time.

Normal dose: 20 mg amoxicillin/kg weight/day, divided into several times 08 hours apart.

Treatment of otitis media, sinusitis, lower respiratory infections and severe bacterial infections, usual doses: 40 mg of amoxicillin/kg should be severe/day, divided into 08 hours apart, for 05 days.

Dosage for children with renal failure:

Creatinin clearance> 30 ml/min: No dose adjustment. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? The acute reactions occur depending on the hypersensitivity of each individual. The risk is definitely hyperkalemia when taking a very high dose because clavulanic acid is used in the form of potassium salt.

Symptoms:

Abdominal pain, vomiting, diarrhea. A small number of patients with rash, excitement or drowsiness.

Management:

Stop taking medicine immediately. Symptomatic treatment and support if needed.

If an overdose occurs early and there is no contraindication, can cause vomiting or gastric lavage. Hypertension can occur even in people with kidney function.

In case of emergency, call the 115 emergency center immediately or go to the nearest local medical station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Claminat drugs often have unwanted effects (ADR) such as:

Common: diarrhea, itching, nausea, vomiting.

Uncommon: hyperlypes, rash, hepatitis and jaundice, transaminase increases.

Rare: Anaphylaxis reaction, leukopenia, hemolytic anemia, fake colitis, Stevens - Johnson syndrome, interstitial nephritis.

Instructions on how to handle ADR:

If allergic reactions are available, amoxicillin must be stopped and immediately emergency with adrenalin, oxygen breathing, intravenous corticosteroids and ventilation, including endotracheal intubation and never being treated with penicillin or cephalosporin again.

fake colitis:

Mild: Stop drugs.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

CLAMINAT CHAPTER CONCLUSION in the following cases:

Hypersensitivity to the ingredients of the drug or antibiotics group penicillin, cephalosporin.

History of jaundice.

liver failure.

Patients with urinary phenylketon (due to drug containing aspartam).

Be cautious when used

Signs and symptoms of cholestasis jaundice occur rarely when taking the drug but may be severe. However, these symptoms are often recovered and will end after 6 weeks of stopping treatment.

Severe hypersensitivity reactions can sometimes lead to death (anaphylaxis) that have been reported in patients using penicillin antibiotics.

There has been an erythema (diverse) rash that comes with lymphadenopathy (mononoconemosis of infection) in patients using amoxicillin. Should avoid using drugs if suspected of monomeric hyperlemen.

Must periodically check the hematology, liver and kidney function during treatment.

Taking drugs for prolonged drugs sometimes develops resistant bacteria.

Use drugs for women during pregnancy and lactation

Pregnant women:

Experimental research on the reproductive process of animals (mice) has proven when using oral preparations do not cause deformities.

However, because there is little experience in using preparations for pregnant women, it is necessary to avoid using drugs in pregnant women, especially in the first 3 months of pregnancy, except for the necessary case prescribed by a physician.

Women who are breastfeeding:

A very small amount of drugs that can be diffused into breast milk, causing a risk of feeling in the child. Should consider using medicine for this object. Notify the doctor if the patient is breastfeeding.

The effect of driving and operating machinery

The drug does not affect the ability to drive and operate machinery.

Interactive drug

The drug can cause prolonged bleeding and blood clotting time.

The drug can reduce the effectiveness of oral contraceptives, so warns patients to know this.

Probenecid reduces amoxicillin elimination but does not affect the elimination of clavulanic acid.

Nifedipine increases amoxicillin absorption.

Patients with hyperuricemia when using allopurinol along with amoxicillin will increase the ability of amoxicillin.

Medication interactions can affect the activity of the drug or cause side effects.

Patients should notify the doctor or pharmacist a list of the drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Pliers such as fusidic acid, chloramphenicol, tetracyclin can reduce the bactericidal effect of amoxicilin.

Amoxicillin reduces methotrexate secretion, increases toxicity on the gastrointestinal tract and hematopoietic system.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

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