Clamoxyl 250mg GSK oral powder for infection treatment (12 packs)
Dosage form 12 package box
Specifications Amoxicillin
Ingredient Tonsillitis, pharyngitis, otitis media, sinusitis, cystitis, typhoid, H.pylori infection (HP), pneumonia, Lyme disease
Ingredient
| Composition information | Content |
| Amoxicillin | 250mg |
Uses
indications
Clamoxyl 250mg drug is indicated in the following cases:
Amoxicillin should be used based on the official guidelines for antibiotic prescriptions and data on local sensitivity.
Amoxicillin is indicated for the treatment of infections, caused by sensitive bacteria in the following positions:
Bacterial infections such as blood infections, endocarditis and meningitis should be started with high doses of infusion therapy and combined with other antibiotics if suitable.
The sensitivity of bacteria with amoxicillin will vary by geography and time and should refer to the data on local sensitivity if both sampling and sensitivity test if necessary (see pharmacological part).
Pharmacokology
Mechanism of action
Amoxicilin is a semi-semi-synthetic aminopenicillin belonging to the beta-lactam antibiotic group. The drug has a wide antibacterial spectrum against many gram -positive and gram -negative bacteria, which are impacted through inhibition of mucopeptide giving birth into cells. However, Amoxicillin is easily decomposed by beta-lactamase enzymes and therefore antibacterial spectroscopy does not include bacteria that produce these enzymes including staphylococci anti-drug, and all strains of pseudomonas, klebsiella and enterobacter.
Pharmacological effectiveness
The anti -drug resistance ratio depends on geography and time and for certain species can be very high. Information about local drug resistance is very important, especially when treating serious infections.
The sensitivity of microorganisms with amoxicillin on In vitro
Star mark (*) indicates Amoxicillin's clinical effectiveness that has been shown in clinical trials.
† Natural intermediaries when there is no resistance mechanism.
Bacillus anthracis
Enterococcus Faecalis*
beta-hemolytic streptococci*
listeria monocytogenes
bordetella pertussis
Other bacteria:
leptospira icterohaemorrhagiae
treponema pallidum
Escherichia Coli*
haemophilus influenzae*
helicobacter pylori*
proteus mirabilis*
salmonella spp.
shigella spp.
neisseria gonorrhoeae*
Pasteurella spp.
Vibrio Cholerae
Staphylococcus aureus with coagulase*
corynebacterium spp.
Staphylococcus aureus*
streptococcus pneumoniae*
Viridans streaver streptococcal*
Clostridium spp.
other bacteria:
Borrelia Burgdorferi
fusobacterium spp.
Enterococcus Faecium †
acinetobacter spp.
Enerobacter spp.
klebsiella spp.
pseudomonas spp.
bacteroides spp. (many strains of Bacferoides Fragilis resistance).
Other bacteria:
chlamydia spp.
mycoplasma spp.
Legionella spp.
Amoxicillin is quickly absorbed from the intestine with the absorption of 72 to 93%. Absorption does not depend on food.
Distribution
The peak concentration in the blood reaches 1 to 2 hours after use. After using the doses of 250 mg and 500 mg amoxicillin, the average peak concentration in serum has been reported respectively 5.2 mcg/ml and 8.3 mcgml.
Amoxicillin is not much linked to protein, only about 18% of the total drug content in plasma. Amoxicillin diffuses easily into most tissues and body fluids, except for brain fluids and spinal cord. Inflammation is generally increasing the meningitis of penicillin and can also occur with amoxicillin.
Elimination
The main elimination of amoxicillin is through the kidney. About 60 to 70% Amoxicillin is excreted in the form of unchanged urine during the first 6 hours after taking a standard dose. Selling time is about an hour.Amoxicillin is also partially eliminated in the urine in the form of penicilloic acid that is not active at the equivalent of 10 to 25% of the original dose.
Simultaneous use with probenecid slowly excreting Amoxicillin.
A small amount of drugs is also excreted in feces and bile.
Before taking Clamoxyl 250mg GSK oral powder for infection treatment (12 packs)
How to use
Take oral use.
Dosage
depending on the age, sugar, weight and kidney function of the patient as well as the severity of infection and sensitivity of pathogenic bacteria.
Information about dosage provided as a total daily dose, divided into small doses. The most common treatment is 3 times/day.
Should continue treatment from 48 to 72 hours after clinical response. It is recommended to treat at least 10 days for any bacterial infections caused by bacterial bacterial bacterial bacteria to prevent acute rheumatoid fever or glomerulonephritis.The absorption of Amoxicillin is not significantly affected when used with food.
Although Amoxicillin has the characteristics of Penicillin antibiotic groups that are low toxicity, it is advisable to periodically assess the function of the organs, including kidney, liver and hematopoietic function when treated for prolonged treatment.
Patient group
Adults and children over 40 kg
Total daily dose is 750 mg to 3 g, divided into small doses.
Maximum oral dose is recommended for 6 g/day, divided into small doses.
Lyme disease: 4 g/day to treat chronic roses with separate moving (isofated erythema chronicum migrans) and 6 g/day in cases with systemic manifestations, both cases use at least 12 days.
Treatment of h. pylori: Amoxicillin 750 mg to 1 g x 2 times/day in combination with proton pump inhibitors (e.g. Omeprazol, Lansoprazol) and other antibiotics (for example Clarithromycin, Metronidazol) in 7 days.
Children under 40 kg
20 - 50 mg/kg/day, divided into small doses.
Maximum recommended dose: 150 mg/kg/day, divided into small doses.
Lyme disease: 25 - 50 mg/kg/day to treat chronic roses moves individually and 100 mg/kg/day in cases of systemic manifestations, both cases use at least 12 days.
Acute otitis media: can be used 750 mg x 2 times/day for two days as an alternative treatment.
Elderly
Unnecessary dose adjustment; Using dose as adults, unless signs of renal failure (see section below)
kidney failure
glomerular filtration (ml/minute)
Adults and children over 40 kg
Children under 40 kg #
greater than 30
Unnecessary dose adjustment
Unnecessary dose adjustment
10 to 30
Maximum of 500 mg used 2 times daily
15 mg/kg used 2 times daily (up to 500 mg/2 times daily)
up to 500 mg/day
15 mg/kg used 1 time/day (maximum 500 mg)
Patients who are hemolysis
Amoxicillin may be excluded from the circulatory cycle through hemolysis.
Adults and children over 40 kg 15 mg/kg/day used as a single dose every day Before hemolysis, one more dose of 15 mg/kg should be used. To be able to restore the drug concentration within the circulation, another dose of 15 mg/kg should be used after hemolysis.
Children under 6 months of age Recommendation for children (children's dripping formulas) for children under 6 months of age. The usual dose of children's mixture (children's drops) except for the lower respiratory infections is: Preventive endocarditis: Conditions Note the dosage for children Patients without anesthesia. Amoxicillin: Take 2 - 3 g# before 1 hour tips. Can consider the second dose after 6 hours if needed. Under 10 years: 1/2 of adults. Under 5 years old: 1/4 of adult dose. 1. Other antibiotics should be provided if the patient has used penicillin in a month earlier; or allergies to penicillin. Anesthesia patients: not suitable for oral antibiotics Amoxicillin: 1 g of intramuscularly before performing the procedure, taking another 500 mg after 6 hours Under 10 years: 1/2 of the adult's amixicillin dose. 2. To maximize pain at the injection site, amixicillin should be dissolved in 1% sterile lidocaine solution. (A) Patients who have to anesthesia and use penicillin in the previous month (b) Patients with anesthesia and artificial heart valve (c) Patients who have had endocarditis one or more times Amoxicillin: 1 g of intramuscularly with Gentamicin 120 mg intramuscularly, just before anesthesia (if any) or 16 minutes before performing the dental procedure. After 6 hours of taking Amoxicillin 500 mg Under 10 years of 1/2 of adult's amoxicillin dose, Gentamicin dose is 2 mg/kg. See attention 2. 3. Do not mix amoxicillin and gentamicin in the same syringe. 4. Refer to the full prescription information of Gentamicin before prescribing. Preventive for patients without urinary tract infections, surgery or urinary and anesthetic equipment. Production/ gynecological procedures Tricks on the gastrointestinal tract Only for patients with artificial heart valves Under 10 years: 1/2 of the adult's amoxicillin dose, the dose of 2 mg/kg Gentamicin. See the attention 2, 3 and 4 above. Patients without artificial cardiac valves. Patients with artificial heart valves. Amoxicillin 1 g of intramuscularly before performing the procedure. After 6 hours of intramuscular injection amixicillin 500 mg. Like the case of genital urinary surgery. Under 10 years: 1/2 of adults Like the case of urinary - genital surgery. See attention 2 above 5. The second dose can be used amoxicillin philosophy See the attention 2, 3, 4, and 5 above Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Symptoms and signs Effects on the gastrointestinal tract such as nausea, vomiting and diarrhea may be evidence and signs of water/electrolyte imbalance should be treated/symptomatic. Observed the urinary amoxicillin crystal, in some cases leading to renal failure (see caution when used). Treatment There is an amoxicillin that can be removed from the circulatory cycle by hemolysis. What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.
Side Effects
When using Clamoxyl 250mg, you may experience unwanted effects (ADR).
The following convention is used to classify unwanted effects: very popular (> 1/10), popular (1/100 to 1/1000 to 1/10,000 to
Disorders of blood systems and lymph
Very rare:
Infections and parasites
Gastrointestinal disorders
#Popular: diarrhea and nausea.
#uncommon: vomiting.
Very rare:
Very rare:
Kidney and urinary disorders
# The ratio of these unwanted effects is taken from clinical studies with about 6,000 adults and children using Amoxicillin.
Instructions on how to handle ADR
Notify the doctor with unwanted effects when taking the drug.
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
contraindicated
Clamoxyl drug 250mg contraindicated in the following cases:
Caution when using
Before starting treatment with amoxicillin, should ask the patient a need for kidneys on previous hypersensitivity reactions with penicillin or cephalosporin antibiotics. Cross -sensitive between penicillin and cephalosporin has been recorded.
There have been reports on serious hypersensitivity reactions and sometimes fatal (anaphylaxis) in patients using beta-lactam antibiotics. If an allergic reaction occurs, amoxicillin should be stopped and replaced with appropriate therapy. Severe anaphylactic reactions may require immediate emergency treatment with Adrenalin. It may also be necessary for oxygen breathing, intravenous steroids and airway control including intubation.
Avoid using amoxicillin if suspected of mononulopular hypergonia due to the appearance of measles rash accompanied by this disease after using amoxicillin.
For long -term use can sometimes lead to excessive growth of uncertainty bacteria.
Palm of fake colitis has been reported when using antibiotics and with mild to life -threatening severity. Therefore, this diagnostic consideration is very important in patients with diarrhea during or after antibiotics. If diarrhea or prolonged or patients with abdominal pain, should stop treatment immediately and check the patient extra.
There have been abnormal prolonged reports of prothrombin (Inr) but rarely in patients using amoxicillin and oral anticoagulants. Proper control measures should be taken when prescribed simultaneously with anticoagulants. It may be necessary to adjust the oral anticoagulant dose to maintain the desired anticoagulant level.
Should adjust the dose in patients with renal impairment (see the dose section).
Very rare cases of observation that the phenomenon of urinary crystals in patients reduces urine secretion, mainly occurs when used injecting. During high doses of amoxicillin, it is necessary to recommend that patients maintain enough oral fluid and urine output to reduce the ability to cause crystal amoxicillin (see overdose).
Clamoxyl 250mg package contains aspartam, this is a source of phenylalanin and thus should be careful when used in patients with phenylketonuria.
The ability to drive and operate machinery
has not observed the impact on the ability to drive and operate machinery.
Pregnancy
The safety of the drug when used for pregnant women has not been established by controlled studies on pregnant women. Studies have been conducted on mouse fertility and rats at 10 times the doses of human use and these studies show that there is no evidence that causes decline in fertility or damaging embryos related to amoxicillin. Amoxicillin can be used in pregnant women when potential benefits surpassing the risk of being related to treatment.
breastfeeding period
can use amoxicillin during breastfeeding. Except for the risk of sensitivity to a small amount of Amoxicillin excreted into breast milk, no influence for gums is known to breastfeed.
Drug interaction
Probenecid reduces amoxicillin secretion through the renal tubules. Simultaneously used with amoxicillin can lead to increased and prolonged the concentration of amoxicillin in the blood.
Concomitant use of allopurinol during treatment with amoxicillin may cause an increase in the likelihood of allergic reactions on the skin.
Tetracyclin and other bactericidal drugs can effectively hinder the bactericidal effect of amoxicillin.
Recommendations when checking the appearance of urinary glucose during amoxicillin treatment, the method of using oxidase glucose enzymes should be used. Due to the high concentration of amoxicillin in urine tested by chemical measures often lead to false positive results.
Like other antibiotics, Amoxicillin can affect the intestinal microflora, leading to reducing the reabsorption of the estrogen and reducing the effectiveness of oral contraceptives.
In the literature, there are rare cases of Inr in patients using acenocoumarol or warfarin and are prescribed a batch of amoxicillin. If necessary to prescribe simultaneously, should carefully monitor prothrombin or INR time when starting or stopping amoxicillin.
Storage
under 30 ° C.
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