Clavurem 625 Remedica Treatment Treatment of infection (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Amoxicillin, clavulanic acid
Ingredient Urinary infections, cystitis, skin infections and soft tissue, acute bronchitis, lung abscess, chronic bronchitis, pneumonia

Ingredient

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Composition information	Content
Amoxicillin	500mg
Clavulanic Acid	125mg

Uses

Indications

Clavurem drug is indicated in the following cases:

Infection treatment in the following cases:

Heavy respiratory infections: tonsillitis, sinusitis, otitis media have been treated with common antibiotics but does not help. E.coli, Klebsiella and Enerobacter produce: cystitis, urethritis, pyelonephritis (female genital tract infections). Abdominal. But because Amoxicillin is easily destroyed by beta - lactamase, therefore does not work for bacterial strains producing these enzymes (multiple strains of Entobacteriaceae and Haemophilus Influenzae).

Clavulanic acid due to the fermentation of Streptomyces Clavuligerus, which has a beta - lactam structure similar to penicilin, has the ability to inhibit beta - lactamase due to the majority of Gram -negative bacteria and Staphylococcus. Especially, it has a strong inhibition effect of beta - lactamase transmitted via plasmid that resists penicillins and cephalosporins.

pseudomonas aeruginosa. Proteus Morganii and Rettgeri, some entobacter strains and providentia resistant drugs, and staphylococcus aure against methicilin are also resistant to this drug. Clavulanic acid itself has very weak antibacterial effects.

Clavulanic acid helps Amoxicillin not be destroyed by beta-lactamase, while expanding the antibacterial spectrum of amoxicillin effectively to many common bacteria that have resisted amoxicillin, resistant penicillins and other cephalosporins.

It is possible to see Amoxicillin and Clavulanate as an antibacterial poison for pneumoccus, streptococcus beta beta, Staphylococcus (penicilin sensitive strains are not affected by penicilinase), Haemophilus Influenza and Branhamella Catatrhalis including strong products. lactamase. In short, the bactericidal spectrum of the drug includes:

Gram -positive bacteria:

Aerobic type: Streptococcus Faecalis, Streptococcus Pneumoniae, Streptococcus Pyogenes, Streptococcus Viridans, Staphylococcus aureus, Corynebacterium, Bacillus anthracis, Listeria monocytogenes. Clostridium, peptococcus, peptostreptoccus.

Gram -negative bacteria:

Aerobic type: Haemophilus Influenzae, Escherichia Coll, Proteus Mirabilis, Proteus vulgaris, Klebsiella, Salmonella, Shigella, Bordetella, Neisseria Gonorrhoeae, Neisseria Meningitidis, Vibrio Cholerae, Pasteura Multocida. The concentration of these 2 substances in the serum is maximum after 1-2 hours of taking the drug. With a dose of 250 mg (or 500 mg), there will be 5 micrograms/ml (or 8 - 9 micrograms/ml) amoxicillin and about 3 micrograms/ml of clavulanate acid in serum. After 1 hour oral 20 mg/kg amoxicillin + 5mg/kg of clavulanic acid, there will be an average of 8.7 micrograms/ml of amoxicillin and 3.0 micrograms/ml of clavulanic acid in serum. The absorption of the drug is not affected by food and it is best to drink right before meals. Amoxicillin's oral bioactivity is 90% and of Clavulanic acid is 75%. The half -life of amoxicillin in serum is 1-2 hours and of clavulanic acid is about 1 hour.

55 - 70% amoxicillin and 30-40% clavulanic acid are discharged through urine in the form of activity. Probenecid extends the time to eliminate amoxicillin but does not affect the elimination of clavulanic acid.

Before taking Clavurem 625 Remedica Treatment Treatment of infection (2 blisters x 10 tablets)

How to use

Clavurem oral.

Dosage

In case of severe infection and respiratory infection:

Dosage for adults and children over 12 years: a Clavurem tablet 625 mg three times daily, for 5 days. Treatment must not exceed 14 days without examining.

Dosage in patients with renal failure:

Adults:

mild renal failure (Creatinin clearance> 30 ml/min): No change. Hepatic failure:

Use cautiously. Check liver function regularly. There is no data to set the dose regimen.

Use tablets and philana to minimize intolerance in the gastrointestinal tract, use at the beginning of the meal. Treatment time depends on the severity of the infection.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Symptoms of gastrointestinal tract (stomach pain and abdominal pain, vomiting, diarrhea) and liquid and electrolyte balance disorders. Some patients have increased movement and drowsiness.

Treatment

Symptomatic treatment, especially interested in adjusting epidemics and electrolyte balance. Amoxicillin and clavunic acid can be eliminated with dialysis.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Clavurem, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: diarrhea, nausea, vomiting, abdominal stomach, flatulence.

Blood: No report.

Rare, ADR

No report.

Not determined frequency

Gastrointestinal tract: indigestion, gastritis, stomatitis, tongue inflammation, skin mucosal candidiasis, abdominal pain, and fake bowelitis. Sometimes the serious hypersensitivity reaction is deadly when drinking penicillin. Hemolysis, thrombocytopenia, thrombocytopenic hemorrhage, acidic leukemia, leukopenia, granulocytic decrease, plateletic hypernipation. Prothombin has also been encountered in patients treated with Clavurem 625 and anticoagulant drugs. ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Clavurem 625 drug contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug. Pay attention to the patient with a history of jaundice/liver dysfunction due to the use of amoxicillin and clavulanate or penicillin because clavulanic acid causes increased cholestatic risk in the liver, mononucleemia, children under 12 years old.

Precautions when using

Special prudence, especially when taking the drug, is necessary at patients with a history of hypersensitivity to this drug or with penicillin derivatives, as well as in people with a history of asthma.

The ability to drive and operate machinery

There are no studies on the effects of drugs on driving and operating machinery. However, patients should be informed that the phenomenon of restlessness, anxiety, convulsions, dizziness ... may occur during the use of Clavurem.

Pregnancy

There are no adequate studies or controls about the use of amoxicillin and clavulanic acid in pregnant women. As with all drugs, Clavurem 625 must be avoided during pregnancy, especially in the first 3 months of pregnancy, unless there is a clear indication that the benefits for mothers are higher than the risk for the fetus.

Consult your doctor or pharmacist before taking the drug.

Breastfeeding period

during breastfeeding can be used. The drug is not harmful to breastfed children unless there is a risk of sensitivity due to a very small amount of medicine in milk.

Drug interaction

If you are about to use Clavurem, it is important to notify the doctor if you are taking the other drugs, especially the following drugs:

Probenecid, tetracyclin (tetracyclin), allopurinol. Therefore, it is necessary to be careful for patients who are being treated with anticoagulant drugs.

Other types of interactions: When testing the urinary glucose by using copper sulphate reagent, there is a possibility of false positive. Glucose tests should be used based on enzyme reactions with oxydase (Clinistix or TES-TAPE).

Storage

Store at temperatures below 30 ° C, avoid moisture. To out of reach of children.

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