Clealine 100mg Atlantic drugs treat depression symptoms, obsessive forced disorders (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Sertraline
Ingredient Mental disorders, schizophrenia

Ingredient

Composition information	Content
Sertraline	100mg

Uses

Indications

Treatment of depression symptoms, including depression accompanied by anxiety symptoms, in patients with or without a history of manic. After good response, the treatment continues with Sertraline to bring a hybrid in preventing the reinforcement of depression or the next depression recurrence.

Treatment of obsession with obsession (OCD). Next, the initial response of Sertraline maintains the efficiency of the radio, safety and good tolerance during the treatment process that lasts up to 2 years of haunting forced disorder (OCD).

Treatment of pediatric patients with obsessive intensity (OCD).

Treatment of panic, whether or not there is wide panic.

Treatment of stress disorder after injury (PTSD).

Pharmacokology

Pharmacological group: anti -epileptic drugs.

ACT code: N06AB06.

Sertraline is a strong and specific inhibitor of the recovery of serotonin (S-HT) at the tip of the nerve. In clinical doses, serotonin inhibits serotonin in human platelets. It has no stimulating effect, sedation or anti -cholinergic or toxic effect on the heart in animals. Thanks to the selective inhibitory effect of 5-HT recovery, Sertraline does not enhance the activity of the catecholaminergic system.

Sertraline has no affinity for the Muscarinic receptors (Cholinergic system), Serotonergic, Dopaminergic, Adrenergic, Histaminergic, Gaba or Benzodiazepine. Long -term use of animals in animals is associated with the adjustment of norepinephrine receptors in the brain as well as common in antidepressants and anti -obsession with other clinical effects.

Unlike 3 -round antidepressants, there is no weight gain, even a few patients also lose weight when treated with sertraline.

Sertraline proves that it is not likely to cause drug abuse.

pharmacokinetics

absorption and distribution:

Sertraline has dynamic properties depending on the dose, about 50 - 200 mg in humans, after taking the daily dose daily in the range of 50 - 200 mg in 14 days of plasma peak concentrations (cmax) of Sertraline appear in about 4.5 - 8.4 hours after drinking. Animal studies show that sertraline has a large distribution.

Sertraline pharmacokinetic properties in children with obsessive forced children have been shown to be similar to adults (although, pediatric patients using Sertraline are slightly more effective). However, it is recommended to lower the dose in children with low body weight (especially for children from 6 to 12 years old) to avoid too high concentration in plasma.

Metabolism:

Sertraline is metabolized mostly in the head phase in the liver. The main metabolite in plasma is Desmethylsertraline, a significantly less active substance (about 20 times) than the sertraline on the invitro. However, there is no testing on the activity on the Invivo model in patients with colds.

Era:

Semi -selling time of N -Desmethylsertraline is in the range of 62 - 104 hours. Sertraline and N-Desmethylsertraline are metabolized mostly in the human body and produces metabolic substances excreted in feces and urine in unprecedented forms.

Before taking Clealine 100mg Atlantic drugs treat depression symptoms, obsessive forced disorders (6 blisters x 10 tablets)

How to use

Sertraline should be used once a day in the morning or evening, use the same food or not with the same food.

Dosage

Initial treatment:

Depression and obsession with intense disorders:

Use 50 mg/day.

panic disorders and post -injury stress disorders:

Use 25 mg/day.

After a week, the dose should be increased by up to 50 mg x 1 time/day. This dose has been shown to reduce the frequency of the allowances at the beginning of the treatment, which is characteristic of and panic.

Standard dose:

Depression of intense impulse, frightening disorders and stress disorders after injury:

Patients who do not respond to a dose of 50 mg may obtain good results when increasing the dose of treatment. The change of dose should be conducted at a distance of at least 1 week, which can increase to a maximum of 200 mg/day. Sertraline has 24 hours of sale, all changes in dosage should not be done at a distance of less than a week.

The beginning of treatment may be observed within 7 days. However, it is usually necessary to have a longer period of time to be able to meet clear treatment, especially in the obsessive -intensive impulse disorder.

Maintain treatment:

Dosage during long -term treatment should be kept at the lowest level that is effective, then adjusted depending on the degree of treatment.

used in children:

Safety and effectiveness of treatment in children have been formed in patients with forced disorders that haunt the age of 6 - 17 years old.

Pediatric patients from 6 to 12 years old: The starting dose should start 25 mg/ day, increasing to 50 mg/ day after 1 week of treatment.

The next dose may increase, in case of lack of response to 50 mg/day, up to 200 mg/day if necessary.

Pediatric patients aged 13 - 17 years old: Should be started at a dose of 50 mg/ day.

Should consider before increasing the dose exceeding 50 mg/day.

used in the elderly:

Can use the same dose as young patients.

Patients with liver failure:

Sertraline is metabolized mostly in the liver. Be cautious when using sertraline in patients with liver disease. Lower doses should be used or increased the distance between doses in patients with liver failure.

Patients with renal failure:

Most of the sertraline is metabolized in the body, only a small amount in the form of unprocessed is eliminated through the urine, so it is not required to adjust the dose according to the level of renal failure

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? The deaths have also been reported related to the dose of sertraline, mainly when used in combination with other drugs and alcohol. Any overdose must be treated positively.

Overdose symptoms: Sleeping, digestive disorders (nausea and vomiting), tachycardia, tremor, agitation and dizziness, less common than coma.

There is no specific antidote, should set up and maintain a breathing line to ensure adequate oxygen and gas exchange. Activated carbon in combination with Western medicine may be more effective or effective than gastrointestinal lavage. It is not recommended to use vomiting measures. Should monitor important parameters of life and find parallel to the general symptom handling measures and resuscitation measures. Due to the wide distribution of sertraline in the body, measures such as mandatory diuretic, fertilizer, blood transfusion are not possible.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Unknown frequency

Plant nerves: Psalms, penis pain.

Systemic: allergic reactions, allergies, weakness, fatigue, fever and face.

Search for chest pain, hypertension, chest drum, edema around the eye sockets, fainting and heart fast.

Central and peripheral nerves: coma, convulsions, headache, migraine, movement disorders (including towering symptoms such as increased movement, muscle tone, teeth grinding or abnormal gait) abnormal and decreasing sensation.

Endocrine: Increasing milk secretion, increased blood prolactin and hyperthyroidism.

digestive: abdominal pain, pancreatitis, vomiting.

Blood: Changing platelet function, abnormal bleeding (nosebleeds, gastrointestinal bleeding, blood urinating).

Changes in biochemical tests. liver: Severe liver disease (including hepatitis, jaundice and liver failure), an increase in plasma transaminase symptoms (SGOT and SGPT).

Nutrition and metabolism: Hypoglycemia, hyperplasia plasma.

psychiatric: excited, overreacting, anxiety, melancholy symptoms, hallucinations and mental disorders.

Reproduction: irregular menstruation.

Respiratory: Bronchospasm.

Skin: hair loss, angioedema and skin rash (including, rare cases of severe peeling dermatitis). kidney - urinary: edema, urinary retention.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Contraindicated

Patients with a history of hypersensitivity to sertraline.

Simultaneous use of sertraline in patients who are being treated with Monoamine Oxidase inhibitors (IMAO).

Be cautious when using

Monoamine oxidase inhibitors (IMAO):

Cases with serious reactions sometimes lead to deaths that have been reported in patients using sertraline in combination with IMAO. Do not use in combination with imao or within 14 days after stopping treatment with these drugs. Similarly, it must be stopped with sertraline at least 14 days before treatment with IMAO drugs.

Other Serotonergic Agreement drugs:

enhance the nerve transmission effect on the Serotonergic system, should be conducted carefully and should be avoided whenever possible due to the risk of pharmacological interaction.

switch between Serotonin recovery inhibitors (SSRIs), antidepressants or anti -obsession drugs:

Should monitor and have caution assessments when converting, especially from long -lasting drugs like fluoxetine. The time needed to clean the drug from the body before converting from a selective inhibitor to recover serotonin to another drug has not been set up.

Increase manic/ decrease:

Renect/ decrease in revival is also reported in a small percentage of patients with severe emotional disorders, treated with antidepressants and other haunting anti -drug drugs on the market.

epilepsy:

Corruption is a potential risk to the use of anti -obsessive drugs. However, because Sertraline has not been assessed in patients with seizures disorders, it should be avoided for patients with unstable epilepsy that have been controlled, so they should be carefully monitored. Sertraline should be stopped in any patient who develops seizures.

suicide:

Due to the possibility of patients who want to commit suicide associated with depression patients and may exist until there is a significant remission, closely monitor patients in the beginning of treatment.

The ability to drive and operate machinery

The drug has no image on the mental activity. Because psychotropic drugs in general can impair the ability to work in intelligence or muscles necessary for high -risk jobs such as driving or operating machinery. Patients should be cautious.

Pregnancy

Sertraline is recorded related to slow bone formation in the embryo. The drug should only be used only for pregnant women when the benefits that bring greater risks are possible.

The period of breastfeeding

There are very little data related to the concentration of sertraline in milk. There is no recommendation for medication for nursing mothers unless there is a thorough assessment of the doctor that the benefits of treatment bring greater risks than possible risks.

Drug interaction

Monoamine oxidase inhibitors (IMAO): Do not use in combination with disulfiram or use within 14 days after stopping treatment with disulfiram.

Central and alcoholic inhibitors: Not simultaneously used with sertraline.

Lithium: There should be appropriate monitoring measures when using simultaneously sertraline with lithium drugs, this substance can be effectively via the Serotonegic activation mechanism.

Phenytoin: It is recommended to monitor the concentration of phenyltoin in plasma at the beginning of treatment with sertraline and adjust the dose of phenyltoin accordingly.

Sumatriptan: It is necessary to take appropriate patient monitoring measures if clinically required to treat in combination between sertraline and sumatriptan.

drugs that are associated with plasma proteins: Sertraline associated with plasma proteins, there is a potential risk of the interaction between sertraline and other drugs associated with plasma proteins.

warfarin: Simultaneous use causes statistical significance of prothrombin time, the clinical significance of this effect has not been known.

Other drug interactions: simultaneously use Sertraline 200 mg/day with diazepam or tolbutamide causing a bit of change but statistically meant a few pharmacokinetic parameters. Simultaneous use of sertraline with cimetidine causes significantly reducing the clearance of sertraline. There is no interaction between a daily daily sertraline with glibenclamide or digoxin.

Electric shock treatment (ETC): There is no clinical research to establish risks or benefits of combining electric shock and sertraline.

Storage

temperature below 30 ° C, in the original packaging.

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