CLEDOMOX 1000 Tenamyd Treatment of infection cases (2 blisters x 7 tablets)

Dosage form Box of 2 blisters x 7 tablets
Specifications Amoxicillin, clavulanic acid
Ingredient Medopharm

Ingredient

Composition information	Content
Amoxicillin	875mg
Clavulanic Acid	125mg

Uses

indications

CLEDOMOX drug indicated in the following cases:

Amoxicillin + Clavulanate preparations are used for treatment in a short time cases of infections due to the following sensitive bacteria:

Heavy respiratory infections on: tonsillitis, sinusitis, otitis media have been treated with common antibiotics but does not help. CatVrbalis produces beta - lactamase: acute and chronic bronchitis, pneumonia - bronchi. Vehicle, wound infection. honey). But because Amoxicilin is easily destroyed by beta - lactamase, therefore does not work for bacterial strains producing these enzymes (many of En

Clavulanic acid due to the fermentation of Strepxomyces Clavuligerus, has a beta - lactam structure similar to penicillin, capable of inhibiting beta - lactamase due to the majority of Gram -negative bacteria and staphylococcus. Especially, it has a strong inhibition effect of beta - lactamase transmitted via plasmid that resists penicillins and cephalosporins.

Pseudomonas Aeruginosa, Proteus Morganii and Rettgeri, some entobacter strains and providentia resistant drugs, and staphylococcus aure against Methicilin are also resistant to this drug. Clavulanic acid itself has very weak antibacterial effects.

Pharmacokinetics

Clavulanic acid helps amoxicillin not to be destroyed by beta - lactamase, while expanding the antibacterial spectrum of amoxicillin effectively for many common bacteria that have resisted amoxicillin, resistant penicillins and other cephalosporins.

It is possible to see Amoxicilin and Clavulanate as an antibacterial poison for pneumococcus, strepxococcus beta beta, Staphylococcus (penicilin sensitive strains are not affected by penicilinase), Haemophilus influenza and Branhamelia CatVrhalis including strong products. lactamase. In short, the bactericidal street of the drug includes:

Gram -positive bacteria:

Aerobic type:

Strepxococcus Faecalis, Strepxococcus Pneumoniae, Strepxococcus Pyogenes, Strepxococcus Viridans, Staphylococcus aureus, Corynebacterium, Bacillus Anthracis, Listeria Monocytogenes. Type when. Clostridium, pepxococcus, pepxostrepxoccus.

Aerobic type: Haemophilus Influenzae, Escherichia Coli, Proteus Mirabilis, Proteus vulgaris, Klebsiella, Salmonella, Shigella, Bordetella, Neisseria Gonorrhoeae, Neisseria Meningitidis, Vibrio Cholerae, PasteRae Multocida.

Amoxicilin and Clavulanat are easily absorbed by oral. The concentration of these two substances in the serum is up to 1-2 hours of medication. With 250 mg (or 500 mg) will have 5 micrograms/ml (or 8 - 9 micrograms/ml) amoxicillin and about 3 micrograms/ml of clavulanate acid in serum.

After 1 hour oral 20 mg/kg amoxicillin + 5mg/kg Clavulanic acid, there will be an average of 8.7 micrograms/ml of amoxicillin and 3.0 micrograms/ml of clavulanic acid in serum. The absorption of the drug is not affected by food and it is best to drink right before meals.

Amoxicillin's oral bioactivity is 90% and of Clavulanic Acid is 75%.

distribution

Amoxicilin and Clavulanate Potassiurn are all distributed into the lungs, pleura and abdominal array. Only a small amount of amoxicillin and clavulanate potassium into the meningitis are not inflamed, when the meninges are infected, the drug may be added to the meninges. Amoxicillin is attached to 17-20% plasma proteins, clavulanic acid associated with blood protein 22-30% with drug concentration of 1-100 µg/ml. Amoxicillin and clavulanic acid quickly enter the placenta, amoxicillin and clavulanic acid distributing a small amount in breast milk.

transformation

Amoxicillin is partially excreted in the urine in the form of penicilloic acid that does not work with the equivalent of 10 to 25% of the original willow. Clavulanic acid metabolizes strongly in humans and eliminates urine and counterattack in the form of carbon dioxide in the air.

Elimination

The half -life of amoxicillin in serum is 1-2 hours and of Clavulanic acid is about 1 hour. 55 - 70% amoxicillin and 30-40% Clavulanic acid are discharged through urine in the form of activity. Probenecid extends the excretion time of amoxicillin but does not affect the elimination of clavulanic acid.

Before taking CLEDOMOX 1000 Tenamyd Treatment of infection cases (2 blisters x 7 tablets)

How to use

oral medication. Should swallow the whole tablet with water. Can break the tablet to easily swallow and take both half a tablet at the same time. Take medicine at the beginning of the meal.

Do not take medicine for more than 2 weeks without checking the treatment.

Dosage

Dosage is usually expressed in the form of amoxiciin in compounds.

Adults: A tablet 875mg/125mg every 12 hours.

Children:

Children of 40 kg or more, drink at adults.

Children under 40 kg of 825mg/125mg hospital weight are not suitable, requiring more dosage and other content.

Patients with renal failure:

When kidney damage is available, the dose and/or the number of times must be changed to respond to kidney damage.

CRCI below 30 ml/minute: tablets 825mg/125mg are not used.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

Overdose, the drug is low at the variable, because it is well tolerated even at high doses.

In case of reduced kidney function and blood - brain barrier, injection will cause poisoning symptoms. However, general reactions occur depending on the hypersensitivity of each body. The risk is definitely hyperkalemia when using a very high doses because clavulanic acid is used in the form of potassium salt.

Treatment:

Can use the blood part of the blood so that the drug will be removed from the circulation.

Note and recommendations:

If you need more information, please consult a doctor or pharmacist.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Unwanted effects are often related to the dose. When using amoxicillin and potassium clavulanate, except for the common gastrointestinal side effects with more frequency, other side effects in general appear with the same frequency and degree as when using only amoxicillin. Unwanted effects when using amoxicillin mixture and potassium clavulanate oral oral is usually light and transient, less than 3% of patients have to stop taking the drug.

Common, ADR> 1/100

Digestive: diarrhea

Blood: hyperlypes Can be heavy and last for a few months.

Systemic body: Anaphylaxis reaction, edema.

Instructions on how to handle ADR

When there is a serious anaphylactic reaction, it should be processed immediately by epinephrin, oxygen, intravenous corticosteroids.

Transaminase increases: Clinical significance is unknown. Attention should be paid to the elderly and adults, preventing the detection of hepatitis in bile.

Radio, erythema, Stevens - Johnson syndrome, puffer dermatitis: Must stop the drug.

Fake colitis:

If light: Stop drugs.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

CLEDOMOX drug contraindicated in the following cases:

allergies to the beta - lactam group (penicillin, and cephalosporin). Clavulanate or micro -acid penicilin clavulanic acid causes increased risk in the liver.

Be cautious when using

for patients with signs of liver dysfunction.

Signs and symptoms of cholestasis jaundice occur rarely when taking the drug but may be severe. However, these symptoms are often recovered and will end after 6 weeks of stopping treatment.

For people with medium or severe renal impairment, attention should be paid to the dosage (see the dose part).

For patients with a history of hypersensitivity to penicillins may have severe reactions or death (see the contraindications).

For those who use amoxicillin with redness and lymphadenopathy.

Taking drugs for prolonged drugs sometimes develops resistant bacteria.

It is important to pay attention to people with phenylceton - urinary because the problems contain 12.5 mg of aspartam in 5 ml.

Use drugs for pregnant or lactating women

Pregnant women

Experimental research on the reproductive process of mice proved when using oral preparations and injections did not cause deformities. However, because there is little experience in using preparations for pregnant women, the background should be avoided in the use of drugs in pregnant women, especially in the first 3 months, except for the necessary cases prescribed by a physician.

breastfeeding women

During breastfeeding can use preparations. The drug is not harmful to breastfed children unless there is a risk of sensitivity due to a very small amount of medicine in milk.

affects the ability to drive and operate machinery

does not affect the ability to drive and operate machinery.

Interactive drug

The drug can extend the bleeding time and coagulation. Therefore, it is necessary to be cautious with patients being treated with anticoagulants (Warfarin).

Like antibiotics with broad spectrum, the drug can reduce the effectiveness of birth control pills.

Nifedipine increases amoxicillin absorption.

Patients with hyperuricemia when using alopurinol along with amoxicillin will increase the ability of amoxicillin.

There may be antagonists between amoxicillin and bacterial needles such as fusidic acid, chloramphenicol, tetracycline.

Amoxicillin reduces methotrexate secretion, increases toxicity on the secretion system and hematopoietic system. Probenecid when taken right before or simultaneously with amoxicillin reduces amoxicillin elimination, thereby increasing the concentration of amoxicillin in the blood. However, Probenecid does not affect the sale time, the maximum concentration of the drug in the blood (CMAX) and the area under the curve of drug concentration over time in the blood (AUC) of Clavulanic Acid.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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