Clindamycin 150mg Domesco Treatment of infections (5 blisters x 10 tablets)

Dosage form Box of 5 blisters x 10 tablets
Specifications Clindamycin
Ingredient Cervical inflammation, genital infections, blood infections, pulmonary abscess

Ingredient

Composition information	Content
Clindamycin	150mg

Uses

Indications

Clindamycin 150 mg is indicated in cases of treatment of severe anaerobic bacteria infections, especially by Bacteroides Fragilis. Clindamycin is also used to treat gram -positive bacteria such as streptococci, staphylococci (including methicillin resistant strains) and pneumococci. However, due to the high risk of causing fake colitis, Clindamycin is not the first choice, only used when there is no appropriate alternative.

Clindamycin is used to treat sensitive bacterial infections in the following cases:

Ear Nose throat caused by S.pneumoniae resistant penicillin, bronchitis, maxillary, skin, genital, osteoarthritis, blood infection (except meningitis).

Infections in the abdomen such as peritonitis and abscess in the abdomen.

Pus wound infection (surgery or injury).

Property fever (genital tract), severe pelvic infections and female genital tract such as: Membrane inflammation in the uterus, fallopian tube abscess due to gonorrhea, hip cell inflammation.

Coordinate with pyrimethamine to treat Toxoplasma disease.

Preventive: pericarditis in infection when doing teeth, respiratory tract in case of allergies to beta-lactam.

Pharmacy

Clindamycin is an antibiotic belonging to the Lincosamid group. The effect of clindamycin is to link to the mini part of the ribosom part, thus inhibiting the synthesis of bacteria's protein. Clindamycin has a bactericidal effect at low concentrations and bactericidal at high concentrations.

Bacterial resistance mechanism for clindamycin is methylation of RNA in the ribosom part of the bacterial ribosom; This type of resistance is usually through plasmid intermediaries. There is a cross -resistance between clindamycin and erythromycin, because these drugs act on the same position of bacterial ribosom.

In vitro effects of clindamycin for the following bacteria:

Glass Gram -positive bacteria: Staphylococcus aureus, Staphylococcus Epidermiche, Streptococcius (except for S. Faecalis), Pneumococcus.

Anaerobic gram bacillus: Bacteroides (B. Fragilis) and Fusobacterium spp.

Gram -positive bacillus is not born: Propionibacterium, eubacterium and Actinomyces spp.

Anaerobic gram -positive bacteria: peptococcus and peptostreptococcus spp., Clostridium perfringens (except C. Sportogenes and C. Tertium).

Other bacteria: Chlamydia Trachomatis, Toxoplasma Gondii, Plasmodium Falciparum, Pneumocystis Carinii, Gardnerella Vaginalis, Mycoplasma Brominn.

The following bacteria are often resistant to clindamycin: Gram -negative bacillus; Streptococcus Faecalis; Nocardia sp; Neisseria meningitidis; Staphylococcus aureus khang methicillin; Haemophilus Influenzae.

Clindamycin can be taken for sustainable in the acidic environment. Minimum inhibitory concentration: 1.6 micrograms/ml.

pharmacokinetics

about 90 % of oral doses of clindamycin hydrochloride are absorbed. After taking 150 mg, 300 mg and 600 mg of clindamycin, the corresponding plasma peak concentration is 2 - 3 micrograms/ml, 4 and 8 micrograms/ml for 1 hour. In Vivo, Clindamycin hydrochloride quickly hydrolyzed into clindamycin.

Clindamycin is widely distributed in the body's fluid and tissue, including bone, but the distribution does not achieve significant concentrations in cerebrospinal fluid. More than 90% clindamycin binds to plasma proteins. The sale time of the drug is from 2-3 hours but can last in infants and patients with severe renal impairment. About 10 % of oral medications are excreted in the urine in the form of activity or metabolites and about 4 % excreted in stool.

Age does not change clindamycin's kinetic dynamics if normal liver and kidney function.

Before taking Clindamycin 150mg Domesco Treatment of infections (5 blisters x 10 tablets)

How to use

use oral, can be used with food or not, taking hard capsules with a glass of water (lots of water) to avoid irritation.

Dosage

Treatment time with clindamycin depends on the type of infection and the severity of the disease. In bacterial infections caused by streptococcus beta blood -soluble group A, Clindamycin tri must continue at least 10 days. In severe bacterial infections such as pericarditis or osteomyelitis, it must be treated for at least 6 weeks.

Common dose

Adults: 150-450 mg, 6-8 hours/time, a maximum dose of 1.8 g/day.

Children ≥ 30 kg body weight (children can swallow hard capsules): 15 - 20 mg/kg/day, divide 3-4 times.

This drug is not suitable for children under 30 kg of body weight.

Dosage to treat some specific diseases

Children ≥ 30 kg body weight (children can swallow hard capsules)

Mound stomatitis: 15 - 20 mg/kg/day, divided 3-4 doses equal.

Preventive infection in the heart: 20 mg/kg, 30 - 60 minutes before surgery.

Adults

Mind stomatitis: 150-450 mg/time, 6 hours/time, for 7 days, maximum 1.8 g/day.

Preventive infection in the heart: 600 mg, oral 30 -60 minutes before the procedure. Genital tract): For women without clinical manifestations but the fever lasts longer than 48 hours, drink 300 mg, 8 hours/time (if due to Mycoplasma) until the fever is gone.

People with kidney failure and liver failure: Clindamycin should be reduced for patients with severe liver or kidney failure, unnecessary adjustment to reduce the dose of mild to medium to medium and liver disease. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms: Antibiotics are less affected when overdose. Symptoms may be nausea and vomiting. The skin rash may occur if the patient is allergic to antibiotics.

Treatment: Clindamycin's serum sale time is 2.4 hours. Clindamycin may not be removed from the blood with the fertilizer or peritoneal fertilizer. Hemodiac and peritoneal dialysis are ineffective in removing clindamycin in serum. No need for stomach washing. Oral rehydration during severe vomiting and diarrhea. Other measures are indicated depending on the patient's clinical condition. If allergic reactions occur with conventional emergency methods, including corticosteroids, adrenalin and antihistamines.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Clindamycin 150 mg, you may experience unwanted effects (ADR).

Clindamycin is at high risk of causing fake colitis caused by toxins of Clostridium Difficile. This happens when bacteria often destroyed by clindamycin (especially in the elderly and those with renal function). In some patients (0.1 -10 %) of fake colitis can develop very seriously and lead to death. Palm colitis is characterized by: abdominal pain, diarrhea, fever, mucus and blood in the stool. Rectal screening shows yellow patches of yellow patches on the colon mucosa.

clindamycin's Adramycin's Adramycin causes diarrhea can be up to 20 % in patients after taking clindamycin.

Common, ADR> 1/100

Digestive: Nausea, vomiting, diarrhea caused by Clostridium difficile, abdominal pain.

Uncommon, 1/1000

Skin: urticaria, itching, Stevens-Johnson syndrome, rash.

Rare, ADR

Genital, urinary tract inflammation.

Kidney: abnormal kidney function.

Systemic: Anaphylaxis.

Skin: skin due to skin, peeling skin.

blood: Eosin hypernagus; Neutral leukemia recovers, grain leukemia, thrombocytopenia.

Digestive: Palmitis, esophagitis.

liver: jaundice, abnormal liver function.

Instructions on how to handle ADR

Clindamycin stops if diarrhea or colitis occurs, Metronidazole treatment is 250 mg - 500 mg, taken every 6 hours, for 7-10 days. Use anion exchange resin such as: Cholestyramin or Colestipol to absorb the toxins of Clostridium difficile. Cholestyramin is not taken simultaneously with Metronidazol, because Metronidazole is linked to cholestyramin and is inactive. Clindamycin cannot be effectively removed from the blood.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Clindamycin 150 mg drugs for people who are sensitive to clindamycin, lincomycin or any ingredients of the drug.

Be cautious when using

If the patient has continuous diarrhea during the use of clindamycin, the medication should be stopped or only continues to use if the patient monitor is tight and there are the next appropriate treatment therapy.

Be cautious for people with gastrointestinal diseases or a history of colitis. Elderly patients are especially sensitive to drugs, need to carefully monitor bowel movements and diarrhea.

Clindamycin accumulates in people with severe liver failure, so the dose adjustments must be adjusted; If used for a long time, periodic monitoring of liver, kidney and blood cell formula should be monitored.

Using clindamycin can cause bacteria that are not sensitive to over -growing drugs. It is necessary to monitor patients and make antibiotics regularly to take appropriate treatment. Clindamycin needs to be carefully used for people with severe renal failure and liver failure, when using high doses for these patients, they need to monitor clindamycin concentration in serum.

Children under 16 years of age when taking the drug should regularly monitor the function of the organs in the body.

Do not use drugs to treat central nervous system infections.

Clindamycin is poorly tolerated in AIDS patients.

Clindamycin is not safe for patients with porphyrin metabolic disorders, avoiding use for people with acute porphyrin metabolic disorders.

Caution for patients with metabolic disorders related to lactose.

The ability to drive and operate machinery

The drug does not affect patients with driving and operating machinery.

Pregnancy

only use clindamycin when really necessary.

Breastfeeding period

Clindamycin excreted breast milk (about 0.7 - 3.8 micrograms/ml), so avoid breastfeeding during drug treatment.

Medicinal interaction

Clindamycin has the effect of nervous closing nerves, so it can increase the effects of other neurotransmitter drugs, so use very cautious when the patient is taking these drugs and these patients need to be monitored because of the prolonged muscular closing effect.

Clindamycin should not be used simultaneously with the following drugs:

Oral steroidal contraceptives, as reducing the effects of these drugs.

erythromycin, because these drugs act in the same position on bacterial ribosom, so the link of this drug with ribosom bacteria can inhibit the effect of the other drug.

diphenoxylate, Loperamid or Opiat (anti -peristalt substances), these drugs can worsen colitis syndrome due to Clindamycin because they slow down toxins.

Kaolin - pectin, because of reducing Clindamycin absorption.

Clindamycin resists the antibiotic activity of aminoglycosides in vitro. However, this resistance in vivo is not proven, clindamycin has successfully used in combination with an aminoglycoside and unknown activity reduction.

Clindamycin can reduce the effects of typhoid vaccine in the form of oral form

Clindamycin antagonists effectively anti -cholinesterase (neostigmin and pyridostigmin).

Vitamin K antagonistic drugs: Increasing blood clotting test indicators (PT/INR) and/or bleeding in patients treated with clindamycin combination with vitamin K antagonists (for example, warfarin, acenocoumarol). Regular monitoring of blood clotting tests in patients treated with vitamin K antagonists.

Storage

In a dry place, temperatures below 30 ° C, avoid light.

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