Clindastad 150 Stella medicine for infections (5 blisters x 10 tablets)

Dosage form Box of 5 blisters x 10 tablets
Specifications Clindamycin
Ingredient Cervical inflammation, genital infections, blood infections, pulmonary abscess

Ingredient

Composition information	Content
Clindamycin	150mg

Uses

indications

Clindastad 150 drugs are indicated in the following cases:

Because of the high risk of causing fake colitis (see side effects), clindamycin is not the first choice. This medication should be used to treat bacterial infections sensitive to clindamycin such as bacteroides fragilis and Staphylococcus aureus, and especially treat patients who are allergic to penicillin. Clindamycin is used in the following cases:

Preventing pericarditis or infections caused by surgical transplants for people who are allergic to penicillin or those who have been treated for a long time with penicillin.

Lung abscess, severe respiratory infections caused by anaerobic bacteria, streptococcus, staphylococcus and pneumococcus.

Infections in the abdomen such as peritonitis and abscess in the abdomen.

Pus wound infection (surgery or injury).

Blood infection.

Producing fever (genital tract), severe pelvic infections and female genital tract such as: Membrane inflammation in the uterus, ovarian abscess without gonorrhea, pelvic cell inflammation, vaginal infections in the vagina after anaerobic surgery.

Pharmacy

Clindamycin is an antibiotic of the Lincosamid group that has the main bactericidal activity for Gram -positive aerobic bacteria and has a broad spectrum for anaerobic bacteria. Most Gram -negative aerobic bacteria, including intestinal bacteria, are resistant to clindamycin. Lincosamids like clindamycin binds to the 50S subunit of the ribosom that is similar to macrolid groups such as erythromycin and inhibits the early phase of the protein synthesis. The activity of clindamycin is mainly bactericidal although high concentrations can kill slowly for sensitive strains.

Pharmacokinetics

absorption

About 90% of the dose of clindamycin hydrochloride is absorbed through the gastrointestinal tract, the concentration of 2-3 Ug/ml appears within 1 hour after taking the dose of 150 mg, with an average concentration of about 700 nanogam/ml after 6 hours. The peak concentration of plasma is about 4 Ug/ml after the dose of 300 mg and about 8 PG/ml after the dose of 600 mg. The absorption is not significantly reduced by food but the absorption rate may be reduced.

Distribution

Clindamycin is widely distributed in the fluid and tissue of the body, including bone, but not significant concentration in cerebrospinal fluid. The drug diffuses through the placenta during the general circulation of the fetus and is present in breast milk. The drug reaches high concentrations in bile. The drug accumulates in leukocytes and macrophages. More than 90% of clindamycin during circulation associated with plasma proteins. The sale time is from 2-3 hours, but may last longer in infants and patients with severe renal impairment.

Metabolism

Clindamycin is metabolized mainly in the liver into an active metabolic substance N - Demethyl and sulfoxyd, and some other non -active metabolites.

Elimination

About 10% of the dose is excreted into urine in the form of active or metabolic drugs and about 4% are excreted in feces; The rest is secreted in the form of metabolites without activity. The excretion is slow, taking place for days. Hemolysis to eliminate illness from the blood ineffectively.

Before taking Clindastad 150 Stella medicine for infections (5 blisters x 10 tablets)

How to use

Clindastad 150 is used by oral. Should take medicine with 1 full glass of water.

Dosage

Adults

150 - 300 mg clindamycin, every 6 hours, dose of 450 mg, every 6 hours if the infection is severe.

Children

3 - 6 mg/kg body weight, every 6 hours. Children under 1 year of age or weighing less than 10 kg used 37.5 mg, 8 hours; Use oral solution.

To prevent pericarditis or infection due to tissue transplant surgery: Clindamycin 600 mg (10 mg/kg for adults) oral 1-2 hours before surgery and oral 300 mg (5 mg/kg) 6 hours after surgery.

Product fever (genital infection): For women with fever but no clinical manifestation, experience according to experience is: Amoxycilin + Clavulanic acid; But if the fever lasts for more than 48 hours: take Clindamycin 300 mg, every 8 hours (if due to Mycoplasma) until the fever is gone or drinking 500 mg of erythromycin (if due to ureaplasma).

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? Clindamycin's serum sale time is 2.4 hours. Clindamycin cannot be excluded by clinical or abdominal separation.

If there is a serious allergic reaction occurs, it is recommended to be treated with conventional emergency measures such as corticosteroids, adrenalin and antihistamines.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Clindastad 150, you may experience unwanted effects (ADR).

Clindamycin is at high risk of causing fake colitis caused by toxins of Clostridium Difficile. This happens when bacteria often destroyed by the intestinal tract by clindamycin (especially in the elderly and those with reduced renal function).

In some patients (0.1 - 10%) of fake colitis may develop very seriously and lead to death. Palm colitis is characterized by: abdominal pain, diarrhea, fever, mucus and blood in the stool. Rectal screening see yellow patches of yellow on the colon mucosa.

Unwanted effect in the digestive tract accounts for about 8% of patients.

Common

Digestive: Nausea, vomiting, diarrhea due to Clostridium difficile.

Less

DA: You Day.

Other: local response after intramuscular injection, intravenous intravenous inflammation.

Rare

Body: Anaphylaxis.

Blood: Eosin hypernagus; Neutral leukemia recovery.

digestive: fake colitis, esophagitis. liver: Increased liver transaminase recovery.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Clindastad 150 drug contraindicated in the following cases:

Patients with a history of sensitivity to Clindamycin, Lincomycin or any ingredient of the drug.

Be cautious when used

Clindamycin should be used cautiously in patients with a history of gastrointestinal disease, especially colitis and stop when diarrhea or colitis. In middle -aged and elderly female patients prone to serious diarrhea or fake colitis.

Be cautious in allergies.

Periodic examination of liver, kidney and blood cell function in patients treated for a long time and in children.

Caution for patients with a history of colitis.

Recommendation of adjusting the dose and periodic analysis of liver enzyme for patients with severe liver failure.

The ability to drive and operate machinery

The effect of clindamycin on driving or operating machinery has not been systematically evaluated.

Pregnancy

only use clindamycin when really necessary.

The period of breastfeeding

clindamycin is excreted into breast milk (about 0.7 - 3.8 micrograms/ml), so it is advisable to avoid breastfeeding during the drug treatment period.

Drug interaction

Clindamycin can increase the effects of neurotransmitter agents, so should only be used very carefully when the patient is taking these drugs.

Clindamycin should not be used simultaneously with the following drugs:

Oral contraceptive oral contraceptives, as reducing the effects of these drugs.

erythromycin, because these drugs are acting in the same position on bacterial ribosom, so the link of this drug with ribosom bacteria can inhibit the effect of the other drug.

diphenoxylate, Loperamid or Opiat (anti -peristalsis), these drugs can worsen colitis syndrome due to Clindamycin, as they slow down toxins.

Kaolin - pectin, because of reducing clindamycin absorption.

Storage

In closed packaging, dry place. The temperature does not exceed 30 ° C.

Other drugs

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