Clocardigel OPV decreased events caused by atherosclerosis (4 blisters x 7 tablets)

Dosage form Box of 4 blisters x 7 tablets
Specifications Clopidogrel
Ingredient Atherosclerosis, stroke, myocardial infarction, psoriasis, peripheral artery disease, angina

Ingredient

Composition informationContent
Clopidogrel75mg

Uses

Indications

Clocardigel drugs are indicated in cases of reducing atherosclerosis events such as myocardial infarction, stroke and blood vessel deaths in patients who have just had a stroke or myocardial infarction, peripheral artery disease has just been confirmed.

Pharmacokic

Clopidogrel is a strong and specific platelet aggregation inhibitor. The role of platelets has been determined in the pathophysiology of atherosclerosis and cases of thrombosis.

Clopidogrel selectively inhibits adenosine diphosphate (ADP) into platelet receptor, and the consequence of this mount is the intermediate activity ADP of the GPIIB/IIIA complex, thereby inhibiting platelet aggregation.

pharmacokinetics

After oral use repeats the dose of 75 mg/day, Clopidogrel is quickly absorbed. However, the plasma concentration of the mother molecule is very low and below the specified limit (0.00025 mg/l) after 2 hours of use. The minimum absorption is 50% based on the elimination of urine of clopidogrel metabolites.

Clopidogrel is metabolized mainly in the liver and inactive metabolites, which are carboxylic acid derivatives that account for about 85% of the drug component circulating in plasma. This metabolic substance reaches the peak concentration in plasma (approximately 3 mg/l after the dose repeats 75 mg by oral).

When compared to a young healthy volunteer, the plasma concentration of the main metabolite is significantly higher in the elderly (≥ 75 years old).

However, this higher concentration in plasma is not associated with the difference in platelet aggregation and bleeding time. No need to adjust the dose in the elderly.

Before taking Clocardigel OPV decreased events caused by atherosclerosis (4 blisters x 7 tablets)

How to use

Oral drugs.

Dosage

Recent myocardial infarction, recent stroke, or peripheral artery disease has been identified:

recommended dose is 75 mg, orally once a day during or outside meals.

Acute coronary syndrome:

Acute coronary syndrome without ST wave difference (unstable angina/heart infarction with no Q wave), Clopidogrel should be started with a single dosage of 300 mg and then continue at a dose of 75 mg once a day. Aspirin (75 mg - 325 mg once a day) should be started and continued in a combination with clopidogrel.

Patients with acute myocardial infarction with st differentia waves, the recommended dose of Clopidogrel is 75 mg once a day, used in combination with aspirin, attached or does not accompanied by thrombolytic drugs. Can start clopidogrel with load or not.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Should consider appropriate treatment if bleeding.

There is no drug that detoxifies the pharmacological activity of clopidogrel. If you need to adjust the bleeding time of clopidogrel, platelet transmission can limit the effect of clopidogrel.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Clocardigel, you may experience unwanted effects (ADR).

Common, ADR> 1/100

  • No report.

    • Uncommon, 1/1000

  • No report.

    • Rare, ADR

  • No report.

    • Not determined frequency

  • Digestive system: stomach bleeding, intestines, abdominal pain, urination, constipation, vomiting, hyper enzyme, coagulation disorders - bleeding, skin rash, itching.

    • Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Contraindicated

    Clocardigel medicine is contraindicated in the following cases:

  • Sensitive to any ingredients of the drug.
  • Bleeding due to pathology is active such as stomach - intestinal bleeding, hemorrhage hemorrhage or intracranial.

    • Precautions when used

    Use cautiously for patients at risk of bleeding due to injury, surgery or other bleeding diseases (such as ulcers).

    Should stop clopidogrel 7 days before surgery.

    Experience treatment for patients with severe liver disease is limited, should be careful to use clopidogrel for these patients.

    Blood thrombocytopenia (TTP) is reported very rarely using clopidogrel, sometimes occurring after a short time, manifested by plateletal reduction and capillary dissolved hemolytic anemia accompanied by nerve signs, impaired kidney function or fever. The thrombocytopenic hemorrhage is likely to be treated immediately, including plasma filter treatments.

    Experience for patients with severe renal failure is limited. Therefore, be careful when using clopidogrel for these patients.

    Patients may be more susceptible to bruising and the bleeding time lasts longer than usual when using clopidogrel (alone or in combination with aspirin), and the patient should notify the doctor to save any abnormal bleeding (position or time).

    The safety and difference of clopidogrel in children has not been set.

    The ability to drive and operate machinery

    Be careful while driving or operating machinery until you know how Clopidogrel affects you.

    Pregnancy

    There is no full research and good control in pregnant women. It is known that clopidogrel and/or its metabolites pass through the placenta in mice and pregnant rabbits, although there are no evidence in the detected of embryo poisoning or mice and rabbits at oral doses up to 500 mg and 300 mg/kg/day.

    Because the above studies are not always the basis for predicting the influence on humans, Clopidogrel is not recommended during pregnancy.

    Breastfeeding period

    Rat research shows clopidogrel and/or metabolites excreted in milk. Therefore, Clopidogrel should not be used for breastfeeding women.

    Drug interaction

    Clopidogrel increases the effectiveness of aspirin on platelet training on collagen. Safety when used for long term aspirin and clopidogrel have not been set up.

    Be cautious about using non -steroid anti -inflammatory drugs for patients using clopidogrel due to the risk of stomach -intestinal bleeding.

    Increased risk of bleeding if used simultaneously clopidogrel with drugs that affect hemostasis such as platelet inhibitors, thrombolytic drugs, anticoagulants and clinical platelets clinically significant.

    Digoxin, Theophylline, acid neutralizing drugs: There is no pharmacokinetic change of digoxin or theophylline when used simultaneously with clopidogrel. Acid neutralization does not change the absorption of clopidogrel.

    Storage

    Store at temperatures from 150C to 300C, dry place.

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