Clopalvix 75mg Boston prevents atherosclerosis, myocardial infarction (5 blisters x 14 tablets)

Dosage form Box of 5 blisters x 14 tablets
Specifications Clopidogrel
Ingredient Atherosclerosis, stroke, myocardial infarction, psoriasis, peripheral artery disease, angina

Ingredient

Composition information	Content
Clopidogrel	75mg

Uses

indications

Clopalvix drugs are indicated in the following cases:

Atherosclerosis prevention

Myocardial infarction (from a few days to less than 35 days); Magnetic anemia stroke (from 7 days to less than 6 months) or peripheral artery disease was established.

Acute coronary syndrome

Acute coronary syndrome, the ST segment is not different (unpaid angina or myocardial infarction without Q waves), including patients who have recently intervened coronary artery intervention, used in combination with aspirin. There is a low risk of bleeding, clopidogrel is used in combination with aspirin in the case of preventing thrombosis due to atherosclerosis and blood vessels due to thrombosis, including stroke

Pharmacokinus

Clopidogrel is a plateletic collection inhibitor belonging to the structure and pharmaceutical group similar to ticlodipine. Clopidogrel selectively inhibits adenosin diphosphate (ADP) to its receptor in platelets and then activated through the ADP intermediaries of Glucoprotein GPIIB/IIIA complex, thus inhibiting platelet aggregation. Clopidogrel also inhibits the platelet aggregation due to the co -movement elsewhere in addition to blocking the amplification of the bridge activation process from the ADP release.

Clopidogrel is impacted by non -recovery of ADP platelet recovery. As a result, platelets attached clopidogrel are affected later on the platelet life.

Dynamic pharmacokinetics

Clopidogrel is quickly absorbed but not completely after drinking, only at least 50% of the dose is absorbed. Clopidogrel is a precursor and is metabolized mainly in the liver into carboxylic acid.

Clopidogrel and carboxylic acid derivatives have a high ratio of protein.

Clopidogrel and metabolites are eliminated into urine and feces, about 50% of oral doses are found in urine and 46% through feces after 5 days of medication.

Before taking Clopalvix 75mg Boston prevents atherosclerosis, myocardial infarction (5 blisters x 14 tablets)

How to use

Clopalvix is used by oral, no need to pay attention to the meal.

Dosage

Adults and the elderly

Take dose 75 mg 1 time/day.

Children

There is no experience when taking children's drugs. The drug is not recommended to use.

Patients with acute coronary syndrome

Acute coronary syndrome, the ST segment does not differ (unstable angina or myocardial infarction without Q wave): Start treatment with an attack at 300 mg of clopidogrel on the first day, then continue at a dose of 75 mg daily. Combined with Aspirin 75 - 325 mg/day on the following days. Recommendation should be used as aspirin under 100 mg/day.

Patients with acute myocardial infarction

Take the dose of 75 mg x 1 time/day, starting with an attack dose of 300 mg of clopidogrel in combination with aspirin with patients with or without thrombosis. In patients over 75 years old, only dose of 75 mg per day. The treatment process continues for at least 4 weeks.

Patients with atrial fibrillation

Use 75 mg x 1 time/day, then continue to use in combination with 75 - 100 mg aspirin daily.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? It may occur including shortness of breath, exhaustion, prolonged bleeding, stomach -intestinal bleeding and vomiting, proper treatment for treatment if bleeding.

There is no drug that detoxifies the pharmacological activity of clopidogrel. Platelets can limit the effect of clopidogrel.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Clopalvix, you may experience unwanted effects (ADR).

Bleeding: gastric - intestinal bleeding (2.0%), intracranial hemorrhage (0.4%), hemorrhage, bruising, hematoma and nosebleeds. Cases are reported less often than hematoma, bleeding and eye bleeding (mainly conjunctiva).

Digestive system: Abdominal pain, indigestion, vomiting, vomiting, diarrhea, constipation, gastritis.

Skin: rash, itching.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Clopalvix drug contraindicated in the following cases:

Hypersensitivity to clopidogrel or any ingredient of the drug.

Severe liver failure.

Pathological bleeding such as gastrointestinal ulcers or brain bleeding, or any other conditions that cause serious bleeding.

Lactating women.

Be cautious when used

In patients with acute myocardial infarction, do not start treating clopidogrel in the first few days after myocardial infarction.

Clopidogrel extends the bleeding time, so it is necessary to take care of the patient with a caution that increases the risk of bleeding due to trauma, surgery, or other pathologies (especially the stomach - intestines and intraocularities).

Clopidogrel is used carefully for patients with bleeding (such as ulcers).

If the patient is prepared for surgery without wanting to have a platelet resistance effect, then stop using clopidogrel 5 - 7 days before surgery. Not much experience using clopidogrel in patients with liver and kidney failure. Therefore should be cautious when taking medicine for this patient.

Patients need to know that when using clopidogrel is longer than usual, it is necessary to stop taking the drug when bleeding appears and should notify abnormal bleeding to the doctor. Patients should notify the doctor and dentist to know that Clopidogrel is using the surgery schedule and before taking any drug.

The ability to drive and operate machinery

Precautions when taking drugs for drivers and operating machinery.

Pregnancy

There are no adequate studies and control when taking drugs in pregnant women. Clopidogrel is only for pregnant women when necessary.

Lactation period

Contraindicated in breastfeeding women.

Drug interaction

Aspirin: Aspirin does not change the ability to inhibit platelet gathering due to adp of clopidogrel but clopidogrel has the ability to increase Aspirin's efficiency on platelet collection due to collagen. However, simultaneously used with 500 mg of aspirin twice a day does not increase the meaning of prolonging the time of clopidogrel bleeding. Pharmacological interaction between clopidogrel and aspirin may occur, resulting in an increased risk of bleeding. Therefore, it is necessary to be cautious when using this combination.

Non -steroid anti -inflammatory drugs (NSAIDs): In a healthy volunteer study when used in a combination of Naproxen with clopidogrel, there is an increase in hidden stomach bleeding. Be cautious when using NSAID drugs with clopidogrel.

warfarin: Because it may increase the risk of bleeding, it is necessary to be cautious when combining warfarin and clopidogrel.

Heparin: In a healthy clinical study, using clopidogrel meeting with heparin does not require adjusting heparin dose or does not affect heparin coagulation effects. Simultaneous use with heparin does not affect Clopidogrel's platelet aggression to inhibit. Pharmaceutical interaction between clopidogrel and heparin may occur, resulting in an increased risk of bleeding. Therefore, be careful when using this combination.

Blood soluble drugs: The safety of clopidogrel combination and unprocessed thrombolytic drugs should be careful when using this combination.

Coordinate with other drugs: There is no clinical interaction with pharmacological significance when coordinating clopidogrel with Atenolol, Nifedipine, or both Atenolol and Nifedipin drugs. Moreover, Clopidogrel's pharmacological activity is not affected when used in combination with phenobarbital, cimetidine or estrogen. Pharmacokinetics of Digoxin or Theophyllin is not changed when combined with clopidogrel.

Storage

Where dry, less than 30 ° C, avoid light.

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