Clopalvix Plus Boston treats acute coronary syndrome without increasing ST segment (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Aspirin, clopidogrel
Ingredient Boston Vietnam Pharmaceutical Joint Stock Company

Ingredient

Composition information	Content
Aspirin	75mg
Clopidogrel	75mg

Uses

indications

Clopalvix Plus drugs indicated treatment in the following cases:

Acute coronary syndrome does not increase the ST segment (using the drug within 12 months). Platelet collection belongs to Thienopyridin group. Clopidogrel selectively inhibits adenosin diphosphate (ADP) to its receptor in platelets and thereby inhibit the activity through the ADP intermediaries of Glycoprotein GPIIB/IIIA complex, thus inhibiting platelet aggregation.

Dioxinity derivatives are made up of clopidogrel oxidation into 2-oxoclopidogrel and dehydrate this intermediate metabolic. The active metabolic form will be quickly and not recovered from the receptor of the platelet ADP, inhibiting platelets. Clopidogrel also inhibits platelet collection caused by other stimulants by secreting ADP to block platelet activity.

Aspirin is absorbed quickly at a high level. Aspirin inhibits Cycloxygenase, thus inhibits prostaglandin synthesis. After salicylic acid levels decrease, cells have the ability to synthesize cyclooxygenase to continue synthesizing prostaglandin. Platelets are non -nuclei cells, unable to synthesize cyclooxygenase, which is not inhibited, until platelets are formed. Thus, aspirin is not inhibited with platelets, until platelets are formed.

Dynamic pharmacokinetics

Clopidogrel is quickly absorbed but not completely after drinking, at least 50% of the dose is absorbed. Clopidogrel is a precursor and is metabolized mainly in the liver into carboxylic acid. The active metabolite is the derivative but not found in plasma. Clopidogrel and metabolites are fitted with proteins and are eliminated to urine and feces, about 50% of oral dose found in urine and 46% in feces.

Aspirin is biological and drinking (%) about 68 ± 3. Attached to a 49%plasma protein. Increasing blood urea that decreases to plasma. The clearance (ml/min/kg): 9.3 ± 1.1, the clearance changes in the elderly, people with cirrhosis. Distribution volume (liter/kg): 0.15 ± 0.03. Sell waste time (hours): 0.25 ± 0.03, the semi -waste time changes in hepatitis people. Eliminating the kidneys mainly in the form of free salicylic acid and conjugate metabolites.

Before taking Clopalvix Plus Boston treats acute coronary syndrome without increasing ST segment (3 blisters x 10 tablets)

How to use

Clopalvix Plus is used by oral, once a day, along with meals or after eating.

Dosage

Adults and the elderly: Take 1 tablet, do not take medicine for more than 12 months.

Children: Safe and effective of the use of drugs that have not been fully studied. Aspirin is likely to cause Reye syndrome in children, this syndrome can cause death for children (rare). Do not recommend using drugs for children.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? Conduct appropriate treatment if bleeding appears. Can be tinnitus, hearing loss, dizziness, dizziness, respiratory alkaline infection, metabolic acid infection, cardiovascular spasm, respiratory failure, blood sugar reduction ...

There is no drug that detoxifies the pharmacological activity of clopidogrel. Platelets can limit the effect of clopidogrel.

When aspirin poisoning, hospitalized patients, acid -base balance, bloody and abdominal fertilizer (if necessary). Sodium bicarbonate and potassium chloride can be transmitted to patients.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Clopalvix Plus drugs often experience unwanted effects (ADR) such as:

Bleeding: gastric - intestinal bleeding (2.0%), intracranial hemorrhage (0.4%), hemorrhage, bruising, hematoma and nosebleeds. Cases are reported less often than blood, bleeding and eye bleeding (mainly conjunctiva). Rash, itching.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Clopalvix plus drugs contraindicated in the following cases:

Hypersensitivity to clopidogrel, aspirin or any ingredients of the drug. Nasal polyps, mast hypertonic patients because acetylsalicylic acid can worse sensitivity (including circulatory failure with flushing, lowering blood pressure, fast heartbeat, vomiting). Hey.

Be cautious when using

Clopalvix Plus extends the bleeding time, so it is cautious for patients who are at risk of increased bleeding due to trauma, surgery or other diseases:

Patients prescribed surgery and no need for plateletal anti -platelets: Stop medication before surgery 7 days.

is very careful when using drugs for patients with eye sphere damage to eye bleeding, a history of gastrointestinal tumors, stomach bleeding or diseases in the gastrointestinal tract, warning the risk of gastrointestinal tract and bleeding for patients even without previous symptoms.

Patients who are tending to bleed or are using drugs may increase the damage in the stomach - intestines or eyeballs.

Notice to patients with side effects that may be encountered and how to handle, slow clotting when using the drug. Before performing surgery or dental care, before using any other drugs, patients need to notify the doctor and dentist about the use of Clopalvix Plus.

Consider the benefits of treatment when taking drugs for patients with a history of asthma, allergic disorders, gout (because aspirin increases urate levels).

Simultaneous use of aspirin and chloropropamide can hypoglycemia. Patients with diabetes when using large dose aspirin may have endogenous hypoglycemia as well as hyperglycemia (due to the complicated metabolism of carbohydrates).

Tinnitus is a sign of metabolism of salicylic. Must monitor medical closely when using the drug.

Stop drugs 7 days before coronary circulation surgery.

Be cautious when used for children

The effect of the drug on the ability to drive and operate machinery

unknown effects of the drug.

Use drugs for women during pregnancy and lactation

Follow the prescription from the doctor. The drug should only be used when the benefits are out of risks.

Drug interaction

can increase the risk of bleeding, so it is necessary to be cautious when coordinating Clopalvix Plus with Warfarin, Heparin, Bupropion, Diazepam, Phenytoin, Tamoxifen, Tolbutamide, Fluvastatin, or other anticoagulants and hemolysis.

Not simultaneously simultaneously Omeprazol or Esomeprazol with Clopalvix Plus.

dexlansoprazol, Lansoprazol and pantoprazole have little effect on platelograph's anti -platelog collection ability Hon omeprazol and esomeprazol.

When using Clopalvix Plus with Methotrexate, the Aspirin component of Clopalvix Plus can inhibit the kidney mode in the kidneys of the methotretate, leading to bone marrow toxicity, salicylate is also replaced with methotrexate attached to albumin.

Coordinate with other drugs: There is no clinical interaction about pharmacological force when combining clopidogrel with Atenolol, Nifedipine or both Atenolol and Nifedipin drugs. Moreover, Clopidogrel's learning energy is not affected when combined with phenobarbital, cimetidine or estrogen. Pharmacokinetics of Dogoxin or Theophyllin is not changed when combined with clopidogrel.

Unused and simultaneously clopalvix plus with drugs with salicylate ingredients, uric acid excretion increased drugs.

Do not use shared drugs with other nasids because of the increased risk of side effects on the gastric - intestinal system including bleeding, aspirin will replace Diclofenac's cohesion position that reduces the effectiveness of DiClofenac. Ibuprofen reduces anti -platelet aggregation effect of aspirin thus increasing the risk of cardiovascular disease.

When taking drugs for older patients, patients show signs of renal function impairment, should be very careful and monitor kidney function before and after treatment in combination with transferred inhibitors, anti -inflammatory drugs, thiazide diuretic.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

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