Clopidogrel 75 - MV USP reduces or prevention of thrombotic events (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Clopidogrel
Ingredient US Pharma USA Joint Stock Company

Ingredient

Composition information	Content
Clopidogrel	75mg

Uses

Indications

Clopidogrel 75 MV is indicated in the following cases:

Reduce or prevent thrombosis due to atherosclerosis (myocardial infarction, stroke, stroke) in patients with a history of atherosclerosis manifested by myocardial infarction (for a few days to less than 35 days), stroke, ischemia (from 7 days to less than 6 months) or peripheral artery disease has been identified.

Used in combination with aspirin in patients with unstable angina syndrome or myocardial infarction without q.

Pharmacology

Clopidogrel is a platelet anti -platelet, affected by non -recovery of platelet recovery. Platelets are adhesive blood cells that help establish thrombosis and contribute to coronary artery blockage. Thanks to the effect of preventing platelet adhesion, Clopidogrel reduces the risk of blood clots (thrombosis) in the lumen of artery vessels (atherosclerosis). Thereby reducing the occurrence of thrombosis such as myocardial infarction, stroke, death ... ..

pharmacokinetics

Clopidogrel is a precursor form, after taking the repeated dose of 75 mg/day Clopidogrel is quickly absorbed and metabolized in the liver into two forms are active forms (derivatives) and non -active form (the derivatives of carboxylic acid).

Thiol metabolites are quickly and not recovered from platelet ADP receptors. Carboxylic acid derivatives account for about 85% of plasma circulation drug components.

The sale time of administrative metabolites is 8 hours after the single dose and the repeated dose. Clopidogrel and its metabolites are excreted through feces and urinary tract, 50% of the dose is retained in the urine and 46% is retained in the feces.

Before taking Clopidogrel 75 - MV USP reduces or prevention of thrombotic events (3 blisters x 10 tablets)

How to use

take the Clopidogrel 75 MV tablet with a glass of water. Can be taken during or outside meals.

Dosage

Clopidogrel dose for adults and the elderly:

Take a dose of 1 tablet (75 mg/time/day).

Clopidogrel dose patients with unstable angina or myocardial infarction without q:

Initial 4 tablets (300 mg)/First day. Then continue the dose of 75 mg/day (combined with aspirin 75 - 325 mg/day) in the following days.

There is no data on the safety and effectiveness of Clopidogrel 75 MV for patients under 18.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Bleeding time increased by 1.7 times compared to the dose of 75 mg/day.
Symptoms of acute poisoning: vomiting, exhaustion, shortness of breath and gastrointestinal bleeding.
Management: There is no antidote to Clopidogrel, based on reliable biological basis, timely platelet transmission can reverse the pharmaceutical impact of clopidogrel.

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Clopidogrel 75 MV, you may experience unwanted effects (ADR).

Gastrointestinal bleeding, hematoma, nosebleeds, intracranial hemorrhage, bleeding, eye bleeding, abdominal pain, anorexia, diarrhea, nausea, gastritis, rash, itching.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using Clopidogrel 75 MV, you need to read the user manual carefully and refer to the information below.

Contraindicated

Clopidogrel 75 MV Contrain to the following cases:

Hypersensitivity to any ingredients of the drug.

Bleeding due to pathology is active such as peptic bleeding, retinal hemorrhage or in the intracranial.

Women who are breastfeeding.

Patients with severe liver failure.

Caution when used

Patients are at risk of bleeding caused by trauma, surgery or other bleeding diseases. Should stop using the drug 7 days before surgery.

Patients who take medication longer than usual must stop taking the drug when there is abnormal bleeding and immediately notify the treating doctor.

Be cautious when used for patients with renal failure, liver failure.

The ability to drive and operate machinery

Clopidogrel does not affect the ability to drive train or operate machinery.

Pregnancy and lactation

Experiments on rabbits and mice do not see the effect of clopidogrel causing fetal toxicity. However, no studies have been conducted in pregnant women. Therefore, only use clopidogrel for pregnant women when really necessary.

Experiments on animals shows Clopidogrel and metabolites are excreted in milk. So far, there has been no information on whether Clopidogrel is excreted through breast milk or not. Therefore, it is necessary to consider stopping breastfeeding during the use of clopidogrel or stop clopidogrel depending on the degree of need to take the drug in the mother who is breastfeeding.

Medicinal interaction

should be cautious when using clopidogrel in combination with Asipirin, nonsteroidal anti -inflammatory drugs, heparin, thrombolytic drugs because it is likely to increase the risk of bleeding.

Do not use clopidogrel with warfarin as it can increase the level of bleeding.

Clopidogrel inhibits Cytochrom P450 CYP2C19 so it will affect the metabolic drugs by this enzyme: phenytoin, corticoid, propanolol, ...

Some recent studies have shown that proton pump inhibitors (PPIS) reduce the effect of preventing the plateloon collection of clopidogrel, but there is no clear evidence of this interaction, so it should only be combined with these two drugs when really necessary.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

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