Clorpheniramin Vidipha treatment of allergic rhinitis, year -round and urticaria (10 blisters x 20 tablets)

Dosage form Tablet
Specifications Box of 10 blisters x 20 tablets
Ingredient Chlorpheniramin Maleat
Indication Urticaria, itching, atopic dermatitis, contact dermatitis, sneezing, stuffy nose

Ingredient

Composition information	Content
Chlorpheniramin Maleat	4mg

Uses

Indications

Clorpheniramin 4mg Vidipha is indicated in the following cases:

Treatment allergic rhinitis season and year round.

Other allergies.

coordinated with other drugs to treat cough symptoms and colds . Alkylamin is antihistamine sedation of the first generation. A dextro isomers of drugs are dexclorpheniramine, which is twice as strongly active, such as most other histamine resistance, chlorpheniramine reduces or loses the main effects of histamine in the body by competing in the hype and histamine in reversal in H's receptors, in the tissues on the gastrointestinal tract, vascular and respiratory trails, non -active drugs of histamine or anti -synthetic or synthetic effects Histamine.

Chlorpheniramin Maleat and dexclorpheniramin maleat are used to treat symptoms of allergies such as urticaria, angioedema, allergic rhinitis, allergic membranes, itching. The drug is a common ingredient to treat coughs and colds. However, these preparations must be used carefully for children and often have to avoid for children under two years of age, because of the risk of death.

pharmacokinetic

absorption

Clorpheniramin Maleat absorbs well but is relatively slow because the drug is highly metabolized in the gastrointestinal mucosa and initially metabolic in the liver when drinking and appears in plasma within 30-60 minutes. The concentration of wall peaks is reached for about 2.5 to 6 hours after drinking. About 5 - 45% of the single dose is completely in the form of non -metabolic drugs. Low bioavailability, reaching 25-50%.

Distribution

About 70% of the drug during the circulation is linked to the protein. The distribution volume is about 2.5 to 3.2 liters/kg (adults) and 3.8 liters/kg (children).

Metabolism

chlorpheniramin maleat is fast and highly metabolized. The metabolites include Desmethyl-Didesmethyl-Corpheniramin and some unknown substances, one or more substances of which are active. The concentration of chlorpheniramine in serum is not correlated in accordance with the antihistamine effect because there is an unknown metabolic substance that also works.

Elimination

The drug is excreted mainly in urine in a constant or metabolic form, the excretion depends on the pH and the urine flow. Reduces excretion times when pH pH increases and urine flow decreases. Only a small amount is seen in the feces. Adults have normal liver and kidney function, chlorpheniramin waste time ranges from 12 to 43 hours and for children from 5.2 - 23.1 hours. In patients with chronic renal insufficiency, the selling time lasts up to 280 - 330 hours.

Before taking Clorpheniramin Vidipha treatment of allergic rhinitis, year -round and urticaria (10 blisters x 20 tablets)

How to use

Clorpheniramin 4mg used by oral.

Dosage

Adults and children over 12 years: 1 tablet every 4 - 6 hours. Maximum daily dose: 6 tablets (24mg) for 24 hours.

The elderly, the elderly are prone to anti -cholin effects on the nervous system. It is necessary to consider lower daily doses (for example, maximum of 12mg in 24 hours).

Children from 6 - 12 years old: 1/2 tablets every 4-6 hours. Maximum daily dose: 3 tablets (12mg) for 24 hours.

Do not use for children under 6 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

Treatment of symptoms and supporting life function should pay attention to liver, kidney, respiratory, heart and water balance. Stomach lavage or caused by ipecacuanha syrup. After that, use activated carbon and western medicine to limit absorption. When experiencing hypotension and arrhythmia, it should be actively treated. It is possible to treat convulsions by intravenous diazepam or phenytoin intravenously, which may need blood transfusions in heavy cases.

What to do when forgetting a dose? But if it's almost time for the next dose, only use the following dose. Do not use the dose or add the dose to compensate immediately forget to drink.

Side Effects

When using Clorpheniramin 4mg Vidipha you may experience unwanted effects (ADR).

Very common, ADR> 1/10

Nervous system disorders: sedation, drowsiness.

Common,

Nervous system disorders: Disorders of attention, abnormal coordination, headache dizziness.

Blood disorders and lymphatic systems: Anemia hematopsiia, hematopoiia. tinnitus .

heart disorders: Brushing chest drum, tachycardia, arrhythmia.

Vascular disorders: Hypotension .

Disorders of the digestive system: vomiting, abdominal pain, diarrhea, indigestion .

Hepatic disorders: hepatitis, jaundice.

musculoskeletal and connective tissue disorders: muscle seizures, muscle weakness.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Clorpheniramin 4mg Vidipha drugs are contraindicated in the following cases:

Hypersensitivity to chlorpheniramin or any ingredients of the drug.

Patients with acute asthma attacks.

Bladder neck.

Stomach ulcer, pyloric - duodenum.

nursing mothers, infants and children lack monthly.

Patients taking Monoamin Oxidase inhibitors (Mao) within 14 days, up to the time of treatment with chlorpheniramin.

Precautions when used

The drug increases the risk of urination in people with prostate hypertrophy, urinary tract congestion, pyloric garges and people with myastheniasticks.

The sedative effect of chlorpheniramine increases when drinking alcohol or drinking simultaneously with other sedatives.

There is a risk of respiratory complications, respiratory decline and apnea in people with pulmonary obstruction or children. Precautions when chronic lung disease, shortness of breath or shortness of breath.

There is a risk of tooth decay in the person treating for a long time.

Avoid using patients with glaucoma as glaucoma.

can cause chicken sleep, dizziness, dizziness, blurred vision and mental impairment in some patients.

Elderly.

Do not use for patients with galactose intolerance, lactase deficiency, Glucose-Galactose absorption disorders.

Need to monitor patients when using the drug because the drug contains Tartrazin yellow excipients that can cause allergic reactions.

The ability to drive and operate machinery

Do not take the drug when driving or operating machinery because the drug can cause unwanted effect to sleep, dizziness, dizziness.

Pregnancy

only used when really necessary. Using drugs in the last 3 months of pregnancy can lead to serious reactions (such as epilepsy) in newborns.

Breastfeeding period

Clorpheniramin can be secreted through breast milk and inhibit milk. Should consider or do not breastfeed or do not take the drug, depending on the level of need for the drug for the mother.

Medicinal interaction

Monoamine oxydase inhibitors prolonged and increased anti -secretion effects of antihistamines.

ethanol or sedative drugs can increase the effect of inhibiting the central nervous system of chlorpheniramin.

chlorpheniramine inhibits phenytoin metabolism and can lead to phenytoin poisoning.

Storage

Store in a dry place, the temperature does not exceed 30 ° C, avoiding light.

Other drugs

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