Clostilbegyt medicine 50mg Egis Pharma stimulates ovulation, treat amenorrhea (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Clomifene citrate
Ingredient Infertility, polycystic ovary syndrome, menstruation

Ingredient

Composition information	Content
Clomifene citrate	50mg

Uses

indications

Clostilbegyt indicated treatment in the following cases:

Stimulates ovulation in the cycle of no ovulation, the purpose to get pregnant. Share-frommel.

Lack of sperm.

ATC code: G03G 802

Mechanism of action

Clomiphene Citrate is a optical mixture of CIS isomers (Zuclomiphene) and Trans (Enclomiphene). 30 - 50% of the drug is CIS.

This anti -estrogen compound selectively inhibits oestradiol attached to the hilly area receptor. The drug stimulates ovulation by producing gonadotropin through a feedback mechanism.

Dynamic pharmacokinetics

After taken, the drug is well absorbed from the digestive system. The drug is excreted mainly in feces. In 5 days, 50% of the amount of oral medication is eliminated, 42% in feces, 8% in the urine. After intravenous injection, only 37% of the drug is eliminated. Clomipene can be detected in feces for 6 weeks.

CIS isomers have a longer half -life than trans isomer. In healthy volunteers can detect Zuclomiphene after a month. This shows that there is a re -circulatory re -circulatory, which is specific. Clomiphene may be present in the early stages of pregnancy in women treated with clomiphene to cause ovulation.

Clinical safety data:

Oral toxicity: LD50 is 1700 mg/kg in the most mouse and 5750 mg/kg in mice. There are no figures in human toxicity.

Before taking Clostilbegyt medicine 50mg Egis Pharma stimulates ovulation, treat amenorrhea (1 blister x 10 tablets)

How to use

oral medication.

Dosage

Dosage must be determined depending on the patient based on sensitivity (the reaction of the ovaries.

In case of amenorrhea, it is possible to start treatment at any day.

regimen: 50 mg/day for 5 days, while the reaction of the ovaries must be clinically and tested. Often the ovulation will occur from the 11th to the 15th day of the cycle.

regimen II: Applicable when regimen 1 fails. Take a dose of 100 mg/day for 5 days from the 5th day of the next menstrual cycle. If not causing ovulation, it can be repeated with the above treatment (100 mg).

If you still do not ovulate, stop the drug for 3 months, then continue treatment for 3 menstrual cycles. After that, there is no further treatment. The total dose used in a cycle must not exceed 750 mg.

In the ovarian multi -cyst syndrome, the starting dose must be low (25 mg/day) - because it is vulnerable to stimulation.

In case of amenorrhea after taking birth control pills, the dose of 50 mg daily; Treatment for 5 days usually has results even in the first regimen.

In the case of sperm minority, the daily dose of 50 mg in 6 weeks.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Need to support support after eliminating active ingredients.

There is no data on the ability to eliminate drugs by fertilizer.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Clostilbegyt drugs often experience unwanted effects (ADR) such as:

Common side effects: (> 1%)

Systemic: The flushing of the circuit. out.

Rare side effects: (

digestive: constipation, diarrhea, acute abdominal syndrome. or weight loss. The ovaries can be enlarged and enlarged, especially in Stein-Leventhal syndrome. The ovaries can be up to 4 - 8 cm, in these cases, they must check the basic body temperature and stop the drug if a two -phase temperature appears.

Twins can occur during more treatment than the average in the people.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Clostilbegyt drugs contraindicated in the following cases:

Hypersensitivity to the active ingredient or any other ingredient of the drug. humanity.

Be cautious when using

Need to check regular liver function.

Must have gynecological examination before treatment.

Starting treatment when the total excretion of gonadotropin in the urine is normal or lower than the normal limit, the normal ovaries when examined and have a good coordination of the function of the thyroid and adrenal glands.

If there is no ovulation, it is necessary to eliminate or treat other forms of infertility may have, before the beginning of the therapy regimen.

If the ovaries are enlarged or chemical, it is necessary to stop treating until the size of the ovaries return to normal. In these cases, it is only for lower doses or a short -term treatment and must be monitored during the treatment.

Because it is difficult to calculate the time of ovulation and a deficiency of the body after using Clostilbegyt, it is necessary to prevent prophylaxis with progesterone after conception.

Only use medication under continuous gynecological tests.

In each tablet has 100 mg of lactose. Patients who are not tolerated to lactose should pay attention to this.

The effect of the drug on the ability to drive and operate machinery

Because there is a temporary vision loss when starting treatment, there is no driving or operating machinery due to possible dangers.

Use drugs for women during pregnancy and lactation

Research in animals:

Demons, pregnancy in rats, mice and rabbits when the dose is very high.

Good tolerance of Clomiphene with a dose of 1.5 - 4.5 mg/kg of weight/day.

Data in humans:

When pregnant, Clostilbegyt must be stopped.

There is a deformity after causing ovulation but the ratio is the same as in normal people.

Clomiphene is discharged into breast milk, so it is necessary to take advantage of the drug if you take the medication when breastfeeding.

Drug interaction

No data.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

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