Clozapyl drug 25mg torrent Treatment of schizophrenia (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Clozapine
Ingredient Schizophrenia

Ingredient

Composition information	Content
Clozapine	25mg

Uses

indications

Clozapyl 25 drugs are indicated in the following cases:

Clozapyl is indicated to treat schizophrenia.

Specifically, although clozapine works to prevent the connection of dopamine at the receptors D1, D2, D3 and D5 and have high affinity with the D4 receptor, it does not cause the position to keep the posture and does not inhibit the repetitive behavior as when treated with apomorphine. This is consistent with the view that clozapine prioritizes the effects on the receptors of dopamine in the limbic region rather than the receptors in the pattern area and therefore can help explain why clozapine has little effects of foreign tower.

Clozapine also acts as an antagonist on adrenergic receptors, cholinergic, histaminergic and serotonergic.

Dynamic pharmacokinetics

In humans, Clozapyl tablets (25 mg and 100 mg) have a bioavailability equivalent to the type of clozapine solution. With a dose of 100 mg x 2 times/day, the peak concentration of a stable state in plasma has an average value of 319 ng/ml (the range of oscillation is from 102 - 771 ng/ml), this concentration is achieved after an average of about 2.5 hours (about 1 - 6 hours) after using the drug.

Also at this dose, the minimum concentration of stable state in plasma is an average value of 122 ng/ml (the range of oscillation is from 41 - 343 ng/ml) 100 mg x 2 times/day. Food does not affect the bioavailability of clozapyl so you can take medicine during or outside the meal.

about 97% clozapine binds to serum protein. The interaction between clozapyl and large -sized drugs with protein has not been fully evaluated but may be very important.

Clozapine is metabolized almost completely before being eliminated and it is found that the unprovent form of the drug in the form of stains in the feces and urine. About 50% of the drug used is excreted in urine and 30% in feces.

The derivatives of the drug in the form of demethylation, hydroxylation and n - oxidation are the main components detected both in urine and feces. Pharmacological testing has shown that the metabolic of Demethylation is only very little effect and the metabolites of hydroxylation and o oxidation are absolutely not effective.

If only a single dose of 75 mg, the average selling time of clozapine is 8 hours (the range is from 4 to 12 hours) while if using the dose of 100 mg x 2 times/day, after achieving the average stability of the drug's sale time of 12 hours (the range of oscillation is from 4 - 66 hours).

Test comparing the use of clozapine by single dose and multi -dose has shown that the sale time increases when using clozapine in the multi -dose compared to when used by single dose, proving that the ability of the pharmacokinetics of the drug is dependent on concentration. At the dose levels of 37.5 mg, 75 mg and 150 mg x 2 times/day after reaching a stable state, AUC is found (area under the curve), peak concentration and minimum concentration in plasma ratio ratio to the dose.

Before taking Clozapyl drug 25mg torrent Treatment of schizophrenia (10 blisters x 10 tablets)

How to use

oral medication.

Dosage

Adults

Starting dose 12.5 - 25 mg/day.

Increase the dose 25 - 50 mg daily until 300 - 450 mg/day for 14 days.

Maximum dose: Some patients are treated at higher doses than the above -mentioned dose level and the highest dose allowed to be used is 900 mg/day. However, unwanted effects tend to increase when the patient uses a dose of more than 450 mg/day.

Children

The drug is not recommended for children.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Destiny, sleeping, coma, loss of reflexes, confusion, agitation, intense reflexes, delirium, convulsions, salivation increased, pupil dilatation, blurred vision, non -tolerant heart rate, tachycardia, hypotension, collapse, arrhythmia and respiratory failure.

Overdose

Includes gastric lavage then for patients to drink activated carbon, symptomatic treatment combined with continuous monitoring of cardiovascular and respiratory function, electrolyte control and acid -base balance. Adrenalin should not be used as well as its derivatives to treat symptoms of hypotension and are likely to appear "reverse adrenalin effect". Patients also need to be closely monitored for at least 4 days to prevent late tricks.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Clozapyl 25, you may experience unwanted effects (ADR).

Dizziness and fatigue are the most common side effects when taking the drug. The other unwanted effects of the drug on the central nervous system are epilepsy, dizziness and headache.

Symptoms caused by drugs are caused by drugs, including tremor, restless and stiff.

All of these effects are light and transient. There have been reports on the appearance of symptoms such as dry mouth, sweating disorders and regulating body temperature when taking the drug.

Side effects of the drug on the cardiovascular system tachycardia, hypotension with special posture often appear in the first weeks of the treatment process.

Although very rare, the circulatory failure accompanied by respiratory failure due to drug use has also been reported.

On the digestive tract, side effects such as nausea, vomiting and constipation can also occur. It is also possible to encounter the case of increasing liver enzyme and in very few cases may have biliary obstruction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Clozapyl 25 drug contraindicated in the following cases:

Patients with hypersensitivity to the ingredients of the drug.

Patients with a history of grain leukemia or hemorrhage disorders in bone marrow.

Patients with mental disorders due to alcoholism or toxicity, patients with drug poisoning, in coma and severe central neurasthenia, patients with severe liver and liver disease.

Caution when using

Special Warning

Drugs sold by prescription.

Read the user manual carefully before use.

If you need more information, please consult a doctor.

Please inform your doctor about the adverse effects that occur during use.

To be out of reach of children.

No expired drugs.

Special note

Clozapyl can cause granulocytes. Before starting treatment with clozapyl patient, the patient should be tested to determine the number and white blood cell formula. The determination of the number of white blood cells should be conducted during the treatment period and even must be continued after the treatment has ended, the number of white blood cells needs to be tested weekly for 4 months and then every half a month until the end of 4 weeks after the treatment is stopped.

The ability to drive and operate machinery

No report.

Pregnancy

so far, the safety of clozapine for pregnant women has not been proven so the drug has not been recommended for these subjects.

Breastfeeding period

Animal studies show that clozapine is excreted in milk so mothers are being treated with clozapine should not breastfeed.

Medicinal interaction

Clozapyl can increase the effect on the central nervous system of: alcohol, enzyme inhibitors, central neurological inhibitors such as addictive painkillers, benzodiazepine and H1 anti -histamine drugs. Caution should be used when using clozapyl in patients who are (or just) using benzodiazepine because the combination of drugs can increase the risk of circulatory failure with respiratory failure.

Due to side effects, it is also necessary to use the kidneys while using clozapyl simultaneously with drugs that have anti -cholinergic effects, lower blood pressure or respiratory inhibitors. Some other drugs have the effect of impaired function of bone marrow (for example: carbamazine, captopril and propylthiouracil) may increase the risk of granulocytes if used simultaneously with clozapine.

Storage

Store at temperatures below 30 ° C. Avoid light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.