Codcerin-D drugs longevity treat symptoms of dry cough, cough with phlegm, allergic cough (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Codein Phosphate, Guaifenesin
Ingredient Truong Tho Pharmaceutical Joint Stock Company

Ingredient

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Composition informationContent
Codeine phosphate10mg
Guiifenesin100mg

Uses

indications

codcerin-d drugs are indicated in the following cases:

  • is indicated for patients over 12 years old to treat symptoms of dry or irritating cough, sputum and respiratory ventilation in colds or upper respiratory infections.

    codeine phosphate:

    Codeine is a derivative of phenanthren, whose name is methylmorphin, methyl group replaces the position of hydrogen in the hydroxyl group linked to aromatic nucleus in the morphine molecule, so the codeine has the same pharmacological effect as the morphine, which is analgesic and cough reduction. Compared to Morphin, Codeine is better absorbed in oral form, causing less constipation and less biliary spasms. At the treatment dose, less respiratory inhibitor (60% lower than morphine) and less addictive than morphine and much less pain relief than morphine.

    Codeine and its salt work to reduce cough due to direct effect on cough center in the brain; Codeine dries secretion in the respiratory tract and increases the secretion of the secretion of the bronchi. Codeine is not enough to reduce the cough. Codeine is a cough reduction in the case of dry cough, which causes insomnia.

    GuaiFenesin:

    Guaifenesin has a sputum effect by irritating the gastric mucosa, then stimulates increased secretion in the respiratory tract, increasing the vol As a result, the drug increases cough reflexes and makes it easier to expel phlegm. This mechanism is different from the mechanism of cough drugs, drugs do not lose cough. The drug is indicated to treat symptoms of cough with thick sputum, difficult to spit due to colds, mild upper respiratory tract. The drug is often combined with bronchodilators, nasal congestion, antihistamine or anti -cough drugs.

    Dynamic pharmacokinetics

    codeine phosphate:

    Codeine and its salt are well absorbed through the gastrointestinal tract. After drinking, the peak concentration of Codein Phosphate in the blood is reached after 1 hour. Codeine is metabolized in the liver by reducing methyl (at O-and N-methyl position in the molecule) to form morphine, norcodeine and other metabolites such as Normorphin and Hydrocodon. The transformation into indirect morphine is influenced by Cytochrom P450 Isoenzyme CYP2D6 and this effect is very different due to the effects of the gene structure.

    Codeine and its metabolic products are excreted mainly through the kidneys and into the urine in the form of glucuronic acid. Half of life is 3-4 hours after drinking or intramuscularly. Codeine can be placed in the placenta and distributed into breast milk.

    GuaiFenesin:

    After drinking, the drug absorbs well from the gastrointestinal tract. In the blood, 60% of the drug is hydrolyzed for 7 hours. The metabolites are no longer active and excreted through the kidneys. After taking 400 mg of guaifenesin, no drug is not detected in the intact form in the urine. Half of the lifetime of Guaifenesin about 1 hour.

    • Before taking Codcerin-D drugs longevity treat symptoms of dry cough, cough with phlegm, allergic cough (2 blisters x 10 tablets)

    How to use

    This drug is only used as prescribed by a doctor.

    Tablets are used orally.

    Dosage

    Adults and children over 12 years: Take 1 capsule/time × 3 times/day. Do not use more than 6 times/day. Do not use more than 7 consecutive days.

    Children aged 12-18: To treat a dry or irritating symptom, codcerin -d is not recommended for children with respiratory function impairment (see the "caution when used").

    Children under 12 years of age: contraindicated codcerin-d to treat dry or irritating symptoms (see "Contraindications" section).

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose?

    Symptoms: Central neurological inhibition including respiratory inhibitors, symptoms may develop but not serious except in case combined with central neurological inhibitors such as alcohol or overdose in large amounts. Common vomiting, nausea, pupils. Hypotension and tachycardia may occur but not sure.

    Management: Must recover respiratory by providing control and respiratory support. Consider using activated carbon in case adults use more than 350mg per hour or overdose of 2.5mg/kg (both children and adults). Naloxon indications in case of coma or respiration.

    involving Guaifenesin:

    Acute symptoms: If the Guaifenesin is used than the higher doses than the usual treatment, it can cause nausea, vomiting, stomach discomfort.

    Treatment: Symptomatic treatment and support.

    Chronic: The abuse of preparations containing Guaifenesin can cause kidney stones.

    In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

    What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

    Side Effects

    When using the drug, there are common unwanted effects (ADR) such as:

    involves codeine phosphate:

  • Neurological: hallucinations, restlessness, refreshment, vague, dizziness, drowsiness, disorientation, drug dependence, headache, dizziness. Bile spasms.
  • The immune system: Hypersensitivity reaction includes itching, urticaria, rash.

    Notify the physician with unwanted effects when using the drug.

    • Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    contraindicated

    Codcerin-d drugs contraindicated in the following cases:

  • Do not use cough treatment for people with asthma, respiratory failure.
  • People are sensitive to the ingredients of the drug. Treatment of cough due to high risk of serious and life -threatening reactions.

    Be cautious when using

    need to be very careful when taking the drug for patients in the following cases:

  • The drug contains sorbitol: Be careful when used for patients with allergies to some types of sugar. Objective reaction.

    Related to codeine phosphate:

    Codeine should only be used at the lowest doses that are effective and in the shortest time.

    It is not recommended to use codeine for children who have respiratory problems (for example: shortness of breath or wheezing when sleeping).

    Ask the doctor in the following cases:

  • If you have a long -term or chronic cough, it may be a sign of a more severe condition.

    If you experience symptoms such as: feeling constipation, anorexia, fatigue, sleeping, shallow or slow, stop taking the medicine and call your doctor or pharmacist for advice.

    transformed through CYP2D6:

    Codeine is converted into morphine (active metabolites) through the liver enzyme CYP2D6 in the liver. If part or all of this enzyme is deficient, the patient will not achieve appropriate treatment effect. It is estimated that up to 7% of the white population may lack this enzyme. However, if the patient has a strong or super -fast metabolic metabolic gene, an increased risk of harmful reactions caused by opioid poisoning even in the usual prescription. These patients have the ability to convert codeine into morphine faster, leading to higher serum morphine levels than expected.

    The common symptoms of Opioid poisoning include consciousness, drowsiness, shallow breathing, pupils, nausea, vomiting, constipation and anorexia. In serious cases, symptoms of circulatory and respiratory decline may appear, may be life -threatening and rarely fatal.

    The estimated ratio of people carrying drug metabolism via CYP2D6 super fast in different races is summarized in the table below:

    racial ratio percentage% Á 1.2%to 2% Europe 1% to 2%

    Codeine is not recommended for use in children with respiratory function, including neuromuscular disorders, severe heart or respiratory diseases, upper and lung respiratory infections, multiple trauma or have just undergone major surgery. These factors can worsen the symptoms of Morphin's poisoning.

    The effect of the drug on the ability to drive and operate machinery

    The drug is likely to affect the ability to drive and operate machinery as well as working on high such as causing dizziness or drowsiness. Do not use drugs for people who are driving and operating machines as well as working on high.

    Using drugs for women during pregnancy and lactation

    pregnancy: Not used for pregnant women.

    breastfeeding period: codcerin-d is not recommended for women who are breastfeeding (see the "contraindication" section).

    In the usual dose of treatment, Codeine and metabolites can be present in breast milk at very low doses and does not seem to cause disadvantages to breastfeeding. However, if the patient is a super -fast CYP2D6 metabolic gene, Morphin (the active metabolite of the codeine) may be found in breast milk with higher concentrations and in very rare cases, which can lead to symptoms of opioid poisoning in newborns, which can cause death.

    Drug interaction

    involving codeine phosphate:

    Codeine increases the side effects of anti -Muscarin substances such as dry mouth, urinary retention, constipation (except for inhaled Muscarin resistant).

    rifampicin increases the metabolism of codeine.

    Like opioid groups, Codeine can increase the effects of sedatives such as barbiturat, anesthetic, painkillers, sleeping pills, sedatives and alcohol.

    can stimulate or inhibit the central nervous system when taking opioid analgesics with reversible IMAO inhibitors like Moclobemide. The sedative effect of Codeine can increase when used with three -ring antidepressants, painkillers, sleeping pills, or with antihistamine. Codeine can increase the effect of lowering blood pressure and sedation of anti -psychotic drugs.

    Monoaminase inhibitors Oxidase: IMAO is used with Pethidin that can stimulate or inhibit serious central nervous system (including hypertension or lower blood pressure). Although this is not recorded with codeine, it may occur similarly and therefore should avoid using Codeine when the patient is taking IMAO-B inhibitors and for 2 weeks after stopping the use of the drug.

    Anti -vomiting drugs: Codeine reduces bowel motility so it can slow down the absorption or causing the digestive tract reaction of anti -vomiting drugs for example Metoclopramid and domperidone.

    Cimetidine reduces the metabolism of codeine, leading to increased plasma medication concentration.

    Anti -arrhythmia: may reduce the absorption of Mexiletin or Quinidine at the digestive tract (so it can reduce the effect of codeine).

    Opioid analgesic drugs increase the effectiveness of sodium oxybate, used to treat sleeping eggs and should avoid simultaneous use of sodium oxybate with codeine.

    involving Guaifenesin:

    Do not coordinate Guaifenesin with substances similar to Guaifenesin in cough treatment.

    Using Guaifenesin may give a fake positive result in the vanillylmandelic acid measurement test (VMA) and 5-Hydroxyindoleacetic acid (5-HIAA) in the urine.

    • Storage

    Places dry, cool, avoid sunlight, temperature below 30 ° C.

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