Codcerin e drugs for treating bronchitis, sore throat, pneumonia, cough due to irritation (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Codein Phosphate, Guaifenesin, Clorpheniramin Maleat
Ingredient Truong Tho Pharmaceutical Joint Stock Company

Ingredient

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Composition information	Content
Codeine phosphate	10mg
Guiifenesin	50mg
Chlorpheniramin Maleat	2mg

Uses

indications

codcerin E drugs are indicated for patients over 12 years old to treat symptoms of dry cough or irritation due to bronchitis with phlegm, sore throat, pneumonia, laryngitis, cough due to irritation and allergies.

Pharmacological

No data.

pharmacokinetics

No data.

Before taking Codcerin e drugs for treating bronchitis, sore throat, pneumonia, cough due to irritation (2 blisters x 10 tablets)

How to use

oral tablets. Take the tablet with a glass of water.

Dosage

Adults and children over 12 years: Take 1-2 capsules/time x 3 times/day. Do not use more than 6 times/day. Do not use more than 7 consecutive days. (See conflict).

Note: There is no special requirement on drug treatment after use.

What to do when overdose?

Symptoms: The central neurological inhibitor includes respiratory inhibition, symptoms that may develop but not serious, unless combined with central neurological inhibitors such as alcohol or overdose in large quantities. Common vomiting, nausea, pupils. Hypotension and tachycardia may occur but not sure. Consider using activated carbon in case adults use more than 350mg per hour or overdose of 2.5mg/kg (both children and adults). Naloxon indications in case of coma or respiratory inhibitor.

Acute symptoms: If you take GuaiFenesin compared to the higher doses than the usual treatment can cause nausea, vomiting, stomach discomfort. Maleat:

The dosage of chlorpheniramine is about 25 - 50 mg/kg body weight. Symptoms and overdose oils include a lot of sleep, inversely stimulating the TKTW system, mental disorders, seizures, apnea, convulsions, anti -muscarin effects, hypertonic reactions and cardiovascular collapse, arrhythmia. If the oral overdose can use activated carbon without contraindications and overdose time not exceeding 1 hour. It is possible to treat convulsions with intravenous diazepam or phenytoin intravenously. Blood transfusion may have to be transferred in heavy cases.

However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

involves codeine phosphate:

Neurological: hallucinations, restlessness, refreshment, vague, dizziness, drowsiness, disorientation, drug dependence, headache, dizziness. Bile spasms.

The immune system: Hypersensitivity reaction includes itching, urticaria, rash.

or meet (ADR> 1/10)

Neurological: Drinking, headache.

Common (1/100 Neurological: headache, dizziness, loss of coordination, mental disorders, movement

Hematology: Anemememia, leukemia, leukopenia, thrombocytopenia. At. Unwanted use when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Codcerin E is contraindicated in the following cases:

Do not use cough treatment for people with asthma, respiratory failure.

People are sensitive to the ingredients of the drug. fast.

Be cautious when used

in drugs containing nipagin m, nipasol m: can cause allergic reactions (may occur slowly).

In the drug containing gelatin: can cause allergic reactions.

in the drug contains soybean oil: If you are allergic to soybean oil or peanuts should not be used.

In the drug contains sorbitol: Be cautious when used for patients with allergies to some types of sugar.

In Ponaceau 4R: can cause allergic reactions.

Consider when used for patients with high blood pressure, cardiovascular disease, adrenal dysfunction, prostate hypertrophy.

involves codeine phosphate

Codeine should only be used at the lowest doses that are effective and in the shortest time.

Ask the doctor in the following cases:

If you have a long -term or chronic cough, it may be a sign of a more severe condition.

If you experience symptoms such as: feeling constipation, anorexia, fatigue, sleeping, shallow or slow, stop taking the medicine and call your doctor or be consulted for advice.

metabolized through CYP2D6

Codeine is converted into morphine (active metabolites) through the liver enzyme CYP2D6 in the liver. If part or all of this enzyme is deficient, the patient will not achieve appropriate treatment effect. It is estimated that up to 7% of the white population may lack this enzyme. However, if the patient has a strong or super -fast metabolic metabolic gene, an increased risk of harmful reactions caused by opioid poisoning even in the usual prescription. These patients have the ability to convert codeine into morphine faster, leading to higher serum morphine levels than expected.

The common symptoms of Opioid poisoning include consciousness, drowsiness, shallow breathing, pupils, nausea, vomiting, constipation and anorexia. In serious cases, symptoms of circulatory and respiratory decline may appear, may be life -threatening and rarely fatal.

The estimated ratio of people carrying drug metabolism via CYP2D6 super fast in different races is summarized in the table below:

African Ethiopians: 29%.

African -Americans: 3.4%to 6.5%. 2%.

Patients impaired respiratory function

Codeine is not recommended for use in children with respiratory function, including neuromuscular disorders, severe heart or respiratory diseases, upper and lung respiratory infections, multiple trauma or have just undergone major surgery. These factors can worsen the symptoms of Morphin's poisoning.

related to chlorpheniramin maleat

Be cautious in people with glaucoma such as glaucoma, people with prostate hypertrophy, people with epilepsy, bronchitis, bronchial asthma, liver failure, kidney failure, people with hypertension and cardiovascular disease. Sometimes stimulating paradox, especially in young children, high doses in the elderly or children.

The drug can cause chicken sleep, dizziness, dizziness, blurred vision and mental impairment in some patients and can seriously affect the ability to drive and operate machinery.

Do not use alcohol, antihistamine drugs.

Patients with galactose intolerance, lactose deficiency, poor absorption of glucose-ga-lactose should not be used.

The effect of the drug on the ability to drive and operate machinery

The drug may affect the ability to drive or operate the machine as well as work on high. Need to avoid being used for people who are driving or operating machinery or working on high.

Using drugs for women during pregnancy and lactation

pregnancy: Not used for pregnant women.

Breastfeeding period: codcerin E is not recommended for women who are breastfeeding (see the contraindications).

In the normal treatment dose, Codeine and metabolites can be available in breast milk at very low doses and does not seem to cause adverse effects on breastfed babies. However, if the patient is a super -fast CYP2D6 metabolic gene, Morphin (the active metabolite of the codeine) may be found in breast milk with higher concentrations and in very rare cases, which can lead to symptoms of opioid poisoning in newborns, which can cause death.

Drug interaction

Interactive:

Related to codeine phosphate:

Codeine increases the side effects of resistant Muscarin such as dry mouth, urination, constipation (except for inhaled Muscarin). Alcohol. The sedative effect of Codeine can increase when used with three -round antidepressants, painkillers, sleeping pills or with antihistamine drugs. Codeine can increase the effect of lowering blood pressure and sedation of anti -psychotic drugs. Although this is not recorded with Codeine, it may occur similarly and therefore should avoid using Codeine when the patient is taking IMAO-B inhibitors and for 2 weeks after stopping the use of the drug. Reducing the metabolism of Codeine leads to increased plasma concentrations in plasma. Codeine.

Related to Guishesin Temple:

Do not coordinate Guaifenesin with substances similar to Guaifenesin in cough treatment.

related to chlorpheniramin maleat:

Increased anti -cholinergic effects by Monoamin oxydase inhibitors (Mao).

Testling:

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children, read the user manual carefully before use.

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