Codepect Mega We Care medicine for treatment of dry cough or irritation (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Codeine, glyceryl guaiacolate
Ingredient Dry cough

Ingredient

Composition information	Content
Codeine	10mg
Glyceryl Guaiacolate	100mg

Uses

Indications

Codepect drug indicated for treatment of dry cough or irritation for patients over 12 years old.

Pharmacokinatus

Codeine has the effect of reducing cough due to the direct effect on the cough center in the brain; Codeine dries the respiratory discharge and increases the slope of bronchial secretions. Codeine is not enough to reduce the cough. Codeine is a cough medicine in case of a dry cough.

Glycerin Guaiacolat reduces secretion of secretion, glycerin Guaiacolat increases the effectiveness of cough reflexes and activity of mucus hairs, helping to eliminate mucus in the bronchial.

pharmacokinetics

Codeine and its salt are well absorbed through the digestive tract, the peak concentration in plasma is about 1 hour after taking the phosphate codein. Codeine is converted in the liver (via the cytochrom P450 system) into morphine (about 10% of the methyl codeine to morphine), norcodeine and other metabolites, including Normorphin and Hydrocodon.

Codeine and metabolites are excreted through the kidneys, mainly in the form of combined with glucuronic acid. About 3 - 16% of the dose is excreted in the urine in the form of constant. Selling time is about 2-4 hours. The main metabolite through the kidney is 2-methoxyphenoxy lactic acid.

Glycerin Guaiacolat absorbed through the gastrointestinal tract. Metabolism and excretion through urine.

Before taking Codepect Mega We Care medicine for treatment of dry cough or irritation (10 blisters x 10 tablets)

How to use

Perive codepect tablets.

Dosage

recommended dose:

Adults: A capsule, 3 times a day or as directed by the doctor. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? If you encounter the above symptoms, you should stop taking the medication and consult a doctor.

Management: Must restore respiration by providing control and respiratory support. Naloxon indications immediately by intravenously in severe cases.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using codepect often has unwanted effects (ADR) such as:

Common

Neurological: headache, dizziness, thirst and a different feeling;

Allergic reactions: itching, urticaria;

allergies: anaphylactic reaction; Meet when the lack of drugs is restlessness, tremor, muscle convulsions, sweating, runny nose. May be psychologically dependent on psychological, physical and familiar drugs.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Codepect drugs contraindicated in the following cases:

Patients with Codeine, Glycerin Guaiacolat or any ingredient of the drug. fast.

Precautions when using

Use carefully for adults enlargement prostate, adrenal or thyroid dysfunction.

Be careful when coordinated with phenothiazin, barbiturat, benzodiazepin, Monoamin oxidase inhibitors, three -round antidepressants.

Codeine should only be used at the lowest doses that are effective and in the shortest time.

It is not recommended to use codeine for children who have respiratory problems (for example: shortness of breath or wheezing when sleeping ...).

Note:

Do not take the drug continuously for more than 7 days.

metabolized through CYP2D6

Codeine is converted into morphine (active metabolites) through the liver enzyme CYP2D6 in the liver. If part or all of this enzyme is deficient, the patient will not achieve appropriate treatment effect. It is estimated that up to 7% of the white population may lack this enzyme.

However, if the patient carries a strong or super -fast metabolic metabolic gene, the risk of harmful reactions caused by opioid poisoning even at the usual prescription dose. These patients have the ability to convert codeine into morphine faster, leading to higher serum morphine levels than expected.

The common symptoms of Opioid poisoning include consciousness, drowsiness, shallow breathing, pupils, nausea, vomiting, constipation and anorexia. In serious meetings, symptoms of circulatory and respiratory decline may appear, can be life -threatening and rarely cause death.

The estimated ratio of people carrying drug metabolism via CYP2D6 super fast in different races is summarized in the table below:

race

%ratio

29%

African Americans

3.4% to 6.5%

1.2% to 2%

3.6% to 6.5%

Greeks

6.0%

Hungarian

1.9%

1% to 2%

Codeine is not recommended for use in children with respiratory function, including neuromuscular disorders, heart or respiratory diseases, upper and lung respiratory infections, multiple trauma or moderate surgery. These factors can worsen the symptoms of Morphin poisoning. ”

Drug interaction

When used in combination, it can increase the effectiveness of opiate and anesthetic owners; Pain relievers, sedatives and sleeping pills, 3 -round antidepressants, oxidase monoamine inhibitors, alcohol and other central neurological inhibitors.

Pain effect of codeine increases when mixing with aspirin and paracetamol, but decreases or loss of effect by quinidine.

Codeine reduces cyclosporin metabolism due to inhibition of cytochrom p450.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

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