Colchicin 1mg Traphaco Room recurrence of gout arthritis and long -term treatment of gout (1 blister x 20 tablets)

Dosage form Box of 1 blister x 20 tablets
Specifications Colchicin
Ingredient Gout

Ingredient

Composition information	Content
Colchicin	1mg

Uses

Indications

Colchicin drug 1mg is indicated in the following cases:

Accompanying gout: Colchicin is a drug chosen to reduce pain in acute gout but if used for short -term, indomethacin or phenylbutazon also acts as as colchicin and is tolerated better. Colchicin is also used to diagnose gout arthritis (if there is a response to colchicin therapy, it proves that there is urate crystal because this crystal is difficult to detect, especially when only in small joints).

Room recurrent arthritis caused by gout and long -term treatment of gout: For normal doses, Colchicin proved to be better tolerated and more effective than indomethacin or phenylbutazon. Colchicin is often used in combination with Probenecid to increase backup.

All long -term therapy with medications that reduce uric acid and hypoglycemia due to the synthesis of uric acid synthesis (allopurinol, tisopurin, benzbromaron, except for azapropazon) need to be conducted by colchicin or with non -steroid anti -inflammatory drugs at least one month to avoid urban abacuses.

The use of blood uric acid reduction drugs is only started after treatment of acute gout at least 15 days and coordinated with a dose of 1 mg/day for 1 to 6 months. This can also be applied in cases with abnormalities in purin synthesis, cancers and chemotherapy that causes strong degeneration of nucleic acid. It should be noted that increased uric acid in the blood also occurs in chronic kidney failure, advanced thyroid, alcoholism and patients reducing urine's elimination of urine.

Arthritis in sarcoidose, arthritis with additional pink bodies, acute cartilage with calcium.

Short -term room therapy in the early stages of therapy with allopurinol and uric acid elimination drugs.

Long -term therapy in patients with raw bile fibrosis (Colchicin has a good effect on reducing mortality), patients with cirrhosis (according to a study in Mexico). This is based on the synthesis effect of Colchicin's protein, especially on collagen synthesis.

Colchicin is also used to treat cycle fever.

Pharmacokology

Anti -gout effect

Colchicin reduces the movement of leukemia, inhibits urate micro -micro -micro -micro -micro -micro -micro -micro -micro -micro -micro -micro -micro -microcousts, keeps the formation of lactic acid, keeping the pH normal because the pH is a factor that facilitates the precipitated monosodium urate crystals to create tissues in the joints. The drug does not work on uric acid elimination in urine, concentration, solubility or ability to attach to serum protein of uric acid or urate.

Non -specific anti -inflammatory effect

Colchicin reduces the movement of leukemia, chemical inhibition, metabolism and function of polygamen leukemia, reducing inflammatory reactions. Anti -inflammatory effect of the drug is weak.

Anti -cell effects

Colchicin inhibits the between the metaphase and the later stage (anaphase) of the cell division process due to the impact on the shuttle and the gel - SOL transformation. Gel and soly changes in non -divided cells are also inhibited. Colchicin's anti -mitotic effects cause harmful effects on the increased tissue such as bone marrow, skin and hair. Colchicin used by oral can reduce the absorption of vitamin B12, fat, sodium, potassium, and the lines are actively absorbed as xylose, leading to reduced cholesterol levels and blood A level of blood. These effects due to the small intestinal mucosa are acting of colchicin.

Other effects

Increases capillary endurance, stimulates adrenal glands, decomposes lymphocytes, inhibits sympathetic, stimulates sympathetic, anti -itching, causes diarrhea, inhibits in vitro the ability to stop training and platelet adhesion.

pharmacokinetic pharmacokinetics

Colchicin is absorbed in the digestive tract and goes into the circulatory round of the gut. Plasma peak concentration appears 2 hours after drinking. The drug is absorbed into the tissue, especially the mucosa, liver, kidney, spleen, except for myocardial, muscular and lung muscle. The drug is eliminated mainly in feces and urine (10 - 20%). When the daily dose is 1mg higher, Colchicin will accumulate in tissue and can lead to poisoning.

Before taking Colchicin 1mg Traphaco Room recurrence of gout arthritis and long -term treatment of gout (1 blister x 20 tablets)

How to use

Take oral use.

Dosage

Acute gout

The initial dose is 0.5 - 1.2mg, then every 1-2 hours drink 0.50 - 0.60mg or take 1 - 1.2mg until the pain is gone until the pain is gone or vomiting or diarrhea. The total dose of colchicin averages orally in a 4 - 6mg treatment.

Pain and joint swelling usually decrease after 12 hours and usually go away after the drug 48 - 72 hours. If drinking again, the new drink must be 2-3 days away from the old drink, otherwise the lesions caused by Colchicin have not yet recovered and the drug may be accumulated.

Treatment of raw bile fibrosis

Take 0.5mg Colchicin, twice a day, repeat for days.

Treatment of cirrhosis

Take 5 days a week, 1-2mg per day.

Preventing acute gout attacks in the early stages of treatment with allopurinol or uric acid elimination tanks

500microgam, 2-3 times daily.

Note: In the treatment of gout, Colchicin proved not to work with indomethacin or phenylbutazon and the application was limited due to its toxicity. People often use Indomethacin or another nonsteroidal anti -inflammatory drug instead of Colchicin.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Colchicin poisoning is mainly due to suicide intent. Poisoning is very severe and the mortality rate is very high (30%).

Symptoms of poisoning appear after taking the drug for 1 to 8 hours: abdominal pain and spreading, vomiting, intestinal paralysis, more diarrhea can have blood. There may also be gastritis, joint pain, hypocalcaemia, fever, rash, including rash such as pink rash, then dehydration leading to urinary discharge. Kidney damage leads to urinary disorders and bleeding. The liver is large and the transices increases very high. Severe vascular lesions cause shock and cardiovascular collapse. Blood disorders (leukemia and then leukopen and platelets due to marrow damage), rapid breathing, hair loss (10th day). Severe muscle weakness and can be paralyzed up while the patient is still awake. Difficult prognosis. Deaths usually occur on the 2nd day or the 3rd day due to water -electrolytes, respiratory failure, cardiovascular collapse and blood infection.

There is no specific treatment for poisoning and overdose colchicin. Increase the elimination of pills with gastric lavage and then duodenum and use activated carbon. Supporting treatments are water -electrolyte restoration, systemic antibiotics and digestive antibiotics in high doses, can inject atropine or morphine to reduce abdominal pain, use anti -shock therapy, for oxygen breathing to ensure good respiratory exchange. If there is a renal function, it may be required for artificial kidney or peritoneal.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using a 1mg colchicin drug, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Nausea, vomiting, abdominal pain.

with high doses: severe diarrhea, stomach bleeding, rash, kidney damage.

Uncommon, 1/1000

Peripheral neuritis, hair loss, blood disorders (long -term therapy), reduce sperm (recover).

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Colchicin drug 1mg contraindicated in the following cases:

Severe kidney failure.

Severe liver failure.

Pregnant.

Patients at risk of narrow -angle glaucoma.

Precautions when using

When used to treat acute gout: Be cautious in people with kidney failure or liver failure.

Be cautious for people with heart disease, liver disease, kidney or digestive disease.

Elderly patients with poisoning due to drug accumulation.

The ability to drive and operate machinery

No report.

Pregnancy

Avoid using colchicin for pregnant women.

Breastfeeding period

Colchicin is eliminated through breast milk. People have not seen children poisoned by milk sugar, but the mother can avoid high concentration of drugs in the milk by taking the drug in the evening before going to bed and breastfeeding after 8 hours.

Medicinal interaction

Simultaneous use of Colchicin and Ciclosporin increases the toxicity of ciclosporin.

Colchicin reduces the absorption of vitamin B12 due to the toxic effect of the small intestine. This absorption can be restored.

Storage

In the dry place, temperatures below 30 ° C and avoid light.

Other drugs

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