Colchicine Stella 1mg medicine for acute gout attacks (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Colchicin
Ingredient Stella

Ingredient

Composition information	Content
Colchicin	1mg

Uses

Indications

Colchicine Stella 1mg drug is indicated in the following cases:

Treatment of acute gout attacks and short -term prevention in the beginning treatment process with allopurinol and urinary urinary drugs.

Pharmacokological

Gout is a disease due to uric acid overload in the body. This uric acid overload leads to the formation of very small urate crystals deposited in body tissues, especially in joints. When crystals formed in joints will cause recurrent arthritis attacks (arthritis). Chronic gout can also lead to the deposition of uric acid hard tumors inside and around the joints that can cause joint destruction, impaired kidney function and kidney stones.

It is unknown to completely the exact mechanism of the colchicin in gout, but the drug is associated with reducing lactic acid production by leukocytes, leading to reducing uric acid deposition and reducing phagocytes, accompanied by reduced inflammatory response.

Colchicin is not an analgesic, although the drug has analgesic effect in acute gout attacks. Colchicin is also not an urinary urinary agent and does not prevent the progression of gout into chronic gout arthritis. The drug has a preventive and preventive effect, so it helps to reduce the incidence of acute gout attacks to soothe dull and an uncomfortable pain that patients with gout sometimes feel. In humans and some other animals, Colchicin can cause temporary leukopenia and then white blood cells.

pharmacokinetics

Colchicin's maximum concentration achieved in plasma after 2 hours of drinking. Absolute bioavailability of about 45%. Colchicin is absorbed through the gastrointestinal tract, the colchicin substrate is limited to absorbed by the transportation process by p-glycoprotein. Colchicin high concentrations are found in the kidneys, liver and spleen. Colchicin is Demethylation in the liver by Cytochrom P450 ISOENZYM CYP3A4 that produces two primary metabolites: 2-O-Demethylcolicin and 3-O-Demethylcolchicin, and a secondary metabolic of 10-O-DemethylColicin. The concentration of metabolites in small plasma. Colchicin through the liver cycle. The main elimination road is through the liver, excreting through stool. The renal elimination is about 10-20% in patients with normal renal function. The sale time of Colchicin is about 28 hours. Colchicin passes the placenta and is distributed in breast milk.

Before taking Colchicine Stella 1mg medicine for acute gout attacks (2 blisters x 10 tablets)

How to use

Colchicine Stella 1mg is used by oral.

Dosage

Adults

gout

Start 1mg, followed by 0.5mg every 2-3 hours until the pain is reduced or vomiting or diarrhea. The total dose must not exceed 6mg. Do not repeat the treatment within 3 days.

Coordinate with allopurinol or urinary urinary drugs: 0.5mg x 2-3 times/day.

kidney failure

For mild/medium -sized renal failure (creatinine clearance 10 - 50ml/min) reduces the dose or increases the distance between the dose.

Elderly

Use the drug very carefully.

Children

Not recommended.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Symptoms of acute overdose due to oral colchicin may not appear in the range of 2 - 12 hours. The first signs of toxicity can be a burning sensation and pain in the mouth, throat and difficulty swallowing. Next these symptoms are nausea, vomiting, diarrhea. Diarrhea may be severe and bleeding with abdominal pain and a painful feeling. These symptoms combined with vascular damage can lead to dehydration, hypotension and shock. Weakening many organs can occur and manifest as toxicity on the central nervous system, bone marrow failure, liver cell damage, muscle damage, respiratory failure, heart and kidney damage. Respiratory failure, cardiovascular collapse or blood infection can lead to death. In surviving patients, hair loss, reverse white blood cells and stomatitis may occur about 10 days after acute overdose.

Treatment

Patients should be carefully monitored for a while after an overdose or acute poisoning with Colchicin to detect slow onset of symptoms. In acute poisoning should empty the stomach by sucking the stomach and taking activated carbon doses. May need respiratory assistance. Colchicine can not be separated due to the level of connection into high tissue. The circulation should be maintained and adjusted the fluid balance and electrolytes. Can intramuscular intramuscularly 10mg Morphin Sulphat to reduce severe abdominal spasms.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Colchicine Stella 1mg, you may experience unwanted effects (ADR).

Common

Nausea, vomiting, abdominal pain.

with high doses: severe diarrhea, stomach -intestinal bleeding, rash, kidney damage.

rarely

Peripheral neuritis, hair loss, blood disorders (long -term therapy), reduce sperm (recover).

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Colchicine Stella 1mg drug contraindicated in the following cases:

sensitive to colchicin or any ingredients of the drug.

Colchicin contraindicated for pregnant women.

Do not use for patients with hemorrhage because Colchicin cannot be removed by clinical or blood change.

Do not use for patients with severe renal impairment (creatinine clearance is less than 10ml/minute).

Colchicin contraindicated in patients with renal failure or liver failure.

People who are using p-glycoprotein or strong CYP3A4 inhibitors.

Precautions when using

should use colchicin cautiously for older and weak patients because of the high risk of poisoning due to drug accumulation.

Should take care of medications carefully in people with heart disease, liver disease, gastrointestinal disease or lactating people.

Avoid use for patients with blood disorders.

Dose reduction in patients with mild to medium renal failure.

Dose or stop treatment with colchicin in patients with normal liver and kidney function but are being treated with P-Glycoprotein or strong CYP3A4 inhibitors.

Because lactose contains. Patients with problems with inherited lactose, Lactase Lapping Lapp or slowly absorb Glucose Galactose should not use this drug.

The ability to drive and operate machinery

Unknown.

Pregnancy

Do not use drugs for pregnant women due to the risk of fetal chromosomes.

Breastfeeding period

Drug interaction

Antibiotics: Increased risk of colchicin poisoning when used with clarithromycin and erythromycin especially in patients with kidney failure. There have been rare reports on risks, should not use CYP3A4 inhibitors, macrolids to treat patients with liver or kidney failure using colchicin.

P-glycoprotein hoặc chất ức chế CYP3A4 mạnh: Colchicin chống chỉ định cho những bệnh nhân suy gan, thận dùng thuốc ức chế P-glycoprotein (ciclosporin, rerapamil hoặc quinidin) hoặc chất ức chế CYP3A4 mạnh (ritonavir, atazanalir, indinavir, clarithromycin, telithromycin, Itraconczol, Ketaconazole).

ciclosporin: carefully used colchicin with ciclosporin because it may increase the risk of kidney and muscle toxicity.

Vitamins: Vitamin B12 can be reduced to absorb when using long or high doses of colchicin, causing vitamin deficiency.

Statins: Acute muscle diseases are reported in patients using colchicin with statins. Patients should notify when pain or muscle weakness.

Storage

In closed packaging, dry place, avoiding light. The temperature does not exceed 30 ° C.

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