Coldfed drugs treat symptoms, fever, headache, runny nose, joint pain (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Paracetamol, chlorpheniramine
Ingredient Allergic rhinitis, fever, colds, headache, body aches

Ingredient

Composition information	Content
Paracetamol	400mg
Chlorpheniramine	2mg

Uses

Indications

Treatment of symptoms, fever, headache, runny nose, joint pain, muscle pain.

Pharmacokic

paracetamol is a para-aminophenol conductor that has pain and fever reduction properties. Paracetamol lifts the threshold of pain to treat headaches, muscle pain, joint pain and flu -related diseases.

Clorpheniramine is an antihistamine resistance in H1 receptor. It reduces the effect of histamine through competitive antagonists with histamines at the H1 receptor.

Coldfed is a combination of two drugs that have been shown to reduce unpleasant symptoms caused by the flu, upper respiratory disorders.

Dynamic pharmacokinetics

absorption: Paracetamol is absorbed quickly and almost completely after drinking. Clorpheniramin Maleat absorbs well from the gastrointestinal tract, the drug has an impact of 15 to 30 minutes after drinking. The bioavailability of chlorpheniramin is about 25 to 50%.

Distribution: Paracetamol is quickly distributed in most of the body's tissue, the peak concentration of plasma is achieved within 30 to 60 minutes. About 25% paracetamol in the blood combined with plasma proteins. Clorpheniramin Maleat has a peak plasma concentration of about 2.5 to 6 hours, about 70% of the blood circulation in the blood linked to plasma proteins. Time of action of chlorpheniramin maleat is about 4 to 6 hours.

Metabolism: The drug is metabolized through the liver.

Elimination: The drug is eliminated through the kidneys.

Before taking Coldfed drugs treat symptoms, fever, headache, runny nose, joint pain (10 blisters x 10 tablets)

How to use

Take the tablet with a glass of water.

Dosage

Adults: 1 - 2 capsules/time, 4 hours to drink 1 time, no more than 3 times/day.

Children 7 - 15 years old: ½ - 1 tablet/time, 4 hours to drink 1 time, no more than 3 times/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

paracetamol: nausea, vomiting, anorexia, pale, abdominal pain occur in the first 24 hours when taking the drug. High doses over 10 g paracetamol in adults (lower dose in alcoholics) are at risk of damaged liver cells leading to non -recovery liver necrosis.

Clorpheniramin Maleat: Sediment, Inverse stimulation often TKTW, Mental disorder, seizure, apnea, convulsions, anti -secretion effects Acetylcholin, Dehydration reaction, cardiovascular collapse, arrhythmia.

How to handle: Quickly transfer patients to the hospital to douche the stomach and support treatment. Paracetamol specific detox substance is N-acetylcysteine.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Common, ADR> 1/100

Neurological: Sleeping, sedation.

digestive: dry mouth, nausea, vomiting.

DA: Ban Da.

Blood and lymphatic system: Hematopelli disorders (neutral leukopenia, hypoglycemia, leukopenia), anemia.

kidney: kidney disease, kidney toxicity (when abuse or long -term use).

Uncommon, 1/1000

There is no information from the manufacturer.

Rare, ADR

The immune system: Hypersensitivity reaction.

Neurological: dizziness.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

contraindicated

Coldfed 400mg Contraindicated in the following cases:

allergies to one of the ingredients of the drug.

Patients with G6PD deficiency.

Patients taking Mao inhibitors.

Nursing mothers, babies.

Be cautious when using

avoid taking medicine for too long, avoiding alcohol drinks.

Patients with anemia before.

Patients with phenylceton - urinary.

Patients with kidney failure, liver failure.

Glaucoma narrow angle, urinary retention, prostate hypertrophy, pyloric garges and worsen in patients with myasthenia gravis.

Chronic lung patients, the elderly.

Caution and special warning when using the drug: The doctor needs to warn the patient about the signs of the reaction on the skin rare but serious, even life-threatening such as Stevens-Johnson syndrome, toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute overseas acne syndrome (AGEP).

Symptoms of the above -mentioned syndrome are described as follows:

Stevens-Johnson syndrome (SJS): is an allergy to puffiness, localized puffiness around natural cavities (eyes, nose, mouth, ears, genitals and anus). In addition, it may be accompanied by high fever, pneumonia, liver dysfunction. Diagnosis of Stevens-Johnson syndrome when there are at least 2 naturally damaged cavities.

Poisoned skin necrosis syndrome (Ten): is the most severe allergic drug, including diverse skin lesions (measles, pink, pink or water -pink water forms, damage quickly spread throughout the body); Eye mucosa damage (keratitis, pus conjunctivitis, corneal ulcer); Damage to the gastrointestinal tract (stomatitis, mouth mucosa, pharyngitis, esophagus, stomach, intestines); damage to the mucous membranes of genital tract, urinary tract; There are also serious systemic symptoms (fever, gastrointestinal bleeding, pneumonia, glomerulonephritis, hepatitis ... high mortality rate of 15 - 30%).

Excavity of the acne pustules (AGEP): Small sterile pustules arise on the spreading background. Damage often appears in folds such as armpits, groin, then can spread the whole body. Systemic symptoms are often fever, neutral leukemia tests.

When detecting signs of rash on the first skin or any other hypersensitive reactions, patients need to stop using the drug. People who have had severe skin reactions caused by Paracetamol must not use the drug again and when they come to medical examination and treatment, they need to notify the medical staff on this issue.

The ability to drive and operate machinery

Coldfed 400 mg can cause drowsiness. Patients should be notified to drive or operate machinery when taking the drug.

Pregnancy

should only take the drug when necessary and with the guidance of a doctor.

The period of breastfeeding

should only take the drug when necessary and with the guidance of the doctor.

Interactive drug

Long -term oral high doses of Paracetamol increases the anticoagulant effect of COUMARIN.

Serious body temperature may occur when using high -dose paracetamol with phenothiazin.

chlorpheniramine inhibits phenytoin metabolism and can lead to phenytoin poisoning.

Alcohol or sedatives that cause sleep can increase the central neurological inhibition effect of chlorpheniramin.

Prolonged Mao inhibitors and increase the anti -secretion effect of acetylcholine of antihistamine drugs.

Storage

Store at a temperature not exceeding 30 ° C.

To be out of reach of children.

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