Coldfed drugs treat symptoms, fever, headache, runny nose, joint pain, muscle pain (80 tablets)

Dosage form Tablet
Specifications Box of 80 tablets
Ingredient Paracetamol, chlorpheniramine
Indication Allergic rhinitis, fever, colds, headache, body aches
Contraindication Prostate hypertrophy, anemia, pneumonia

Ingredient

Composition information	Content
Paracetamol	400mg
Chlorpheniramine	2mg

Uses

Indications

Treatment of symptoms, fever, headache, runny nose, joint pain, muscle pain.

Pharmacokology

Pharmacological group:

paracetamol: pain relief, fever.

Clorpheniramin: First -generation antihistamine drugs.

Paracetamol is a para-aminophenol derivative with pain and fever reduction properties. Paracetamol lifts the threshold of pain to treat headaches, muscle pain, joint pain and flu -related diseases.

Clorpheniramine is an antihistamine resistance in H1 receptor. It reduces the effect of histamine through competitive antagonists with histamines at the H1 receptor.

Coldfed is a combination of two drugs that have been shown to reduce the unpleasant symptoms caused by the flu, upper respiratory disorders.

Pharmacokinetics

absorption

Paracetamol is absorbed quickly and almost completely after drinking. The drug is quickly distributed in most body tissues. The peak concentration of plasma is achieved within 30 to 60 minutes.

Clorpheniramin Maleat absorbs well from the digestive tract. The drug has an effect of 15-30 minutes after drinking, the plasma peak concentration is about 2.5 to 6 hours. The bioavailability of chlorpheniramin is about 25-50%. The effect of the drug is about 4-6 hours.

Distribution

About 25% of the blood paracetamol combined with plasma proteins and about 70% chlorpheniramine circulating in the blood in connection with plasma proteins.

Metabolism

The drug is metabolized through the liver.

Elimination

The drug is eliminated through the kidneys.

Before taking Coldfed drugs treat symptoms, fever, headache, runny nose, joint pain, muscle pain (80 tablets)

How to use

Take the tablet with a glass of water.

Dosage

Adults: 1-2 tablets each time, 4 hours to drink 1 time, no more than 3 times a day.

Children 7-15 years old: 1/2 - 1 tablet, every 4 hours, no more than 3 times a day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms of overdose

paracetamol: vomiting, nausea, anorexia, pale, abdominal pain occur in the first 24 hours when taking the drug. High doses over 10 g paracetamol in adults (lower doses in alcoholics) are at risk of ruined liver cells leading to non -recovery liver necrosis.

chlorpheniramin maleat: sedation, inverse stimulation often central nervous system, mental rebellion, seizure, apnea, convulsions, anti -secretion effect acetylcholin, hypertonic reaction, cardiovascular collapse, arrhythmia.

How to handle

Quickly transfer patients to the hospital to douche stomach and support treatment. Paracetamol specific detox substance is N-acetylcysteine.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Coldfed, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Central nervous system: Sleeping, sedation.

Hematology: Dehydration (neutropenia, all bloody hemorrhage, leukopenia), anemia.

kidney: kidney disease, kidney toxicity when abused or long -term use.

Digestive system: Nausea, vomiting, dry mouth.

DA: Ban Da.

Uncommon, 1/1000

Not yet reported.

Rare, ADR

The immune system: Hypersensitivity reaction.

Central nervous system: Dizziness.

Digestive system: Nausea.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Contraindicated

allergies to one of the drug ingredients.

Patients with G6PD deficiency.

Patients use Mao inhibitors.

nursing mothers, babies.

Be cautious when using

avoid taking medicine for too long, avoiding alcohol drinks.

Be cautious of using the drug in patients: patients with anemia in the past, patients with phenylceton - urinary, patients with renal impairment, liver failure, narrow -angle glaucoma, urinary retention, prostate hypertrophy, pyloric obstruction and worse in patients with myasthenia gravis, chronic lung patients, older people.

Caution and special warning when using the drug: The doctor needs to warn the patient about the signs of the skin reaction, although the incidence is not high but serious, even life-threatening including Stevens-Johnson syndrome, toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute overseas acne syndrome (AGEP).

Symptoms of the above -mentioned syndrome are described as follows:

Stevens-Johnson syndrome (SJS): is an allergic to puffiness, localized puffiness around natural cavities: eyes, nose, mouth, ears, genitals and anus. In addition, it may be accompanied by high fever, pneumonia, liver dysfunction. Diagnosis of Stevens-Johnson syndrome when there are at least 2 naturally damaged cavities.

Poisoned skin necrosis syndrome (Ten): is the most severe allergy, including skin lesions (measles, pink, roses or bulls, damage quickly spread throughout the body); Eye mucosa damage (corneal inflammation, blind conjunctivitis, corneal ulcer); Damage to the gastrointestinal tract (stomatitis, mouth mucosa, pharyngeal ulcer, esophagus, stomach, intestines); Damage to genital and urinary tract mucosa. There are also serious systemic symptoms such as fever, gastrointestinal bleeding, pneumonia, glomerulonephritis, hepatitis ... high mortality rate of 15 - 30%.

Excavity of the acne pustules (AGEP): Small sterile pustules arise on the spreading background. Damage often appears in folds such as armpits, groin, then can spread the whole body. Systemic symptoms are often fever, neutral leukemia tests.

When detecting signs of rash on the first skin or any other hypersensitive reactions, patients need to stop using the drug. People who have had severe skin reactions caused by Paracetamol must not use the drug again and when they come to medical examination and treatment, they need to notify the medical staff on this issue.

The ability to drive and operate machinery

Coldfed can cause drowsiness. Patients should not drive or operate machinery when taking the drug.

Pregnancy

should only take the drug when necessary and with the guidance of a physician.

Breastfeeding period

should only take the drug when necessary and with the guidance of the physician.

Interactive drug

Long -term oral high doses of Paracetamol increases the anticoagulant effect of COUMARIN.

Serious body temperature may occur when using high -dose paracetamol with phenothiazin.

chlorpheniramine inhibits phenytoin metabolism and can lead to phenytoin poisoning.

Alcohol or sedatives that cause sleep can increase the central neurological inhibition effect of chlorpheniramin.

Prolonged Mao inhibitors and increase the anti -secretion effect of acetylcholine of antihistamine drugs.

Storage

Store at temperatures not exceeding 30 ° C.

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