Colergis Dexa Silo treat allergies to be treated with corticosteroids (60ml)

Dosage form Box x 60ml
Specifications Betametasona, dexchlorpheniramin maleat
Ingredient PT. Dexa Medica

Ingredient

Thành phần cho 5ml

Composition information	Content
Betametasona	0.25mg
Dexchlorpheniramin maleat	2mg

Uses

Indications

Colergis Siro indicated in case:

Treatment of allergies to be treated with corticosteroids.

Anti -inflammatory effects include lysosome leukemia, preventing hydrolase release from destroying acids from leukocytes, preventing the accumulation of macrophages on inflammatory positions, reducing the grip of white blood cells on capillary endothelium, reducing capillary permeability and edema, against histamine release from the substrate, reducing collagen and other mechanisms.

Anti -inflammatory activity time is suitable for hypothalamus pressing time - pituitary - adrenal (HPA). Colergis can reduce the activity and mass of lymphatic, produce leukopenia, reduce the immune level of antigen -antigen -antibody -interactive reactor in the way to prevent immune reactions.

Betamethasone also stimulates red blood cells in the bone marrow, prolongs the life of red blood cells and platelets in the blood, increases neutrophils and leukocytes, increases protein catabolism, creates gluconeoge and reproduces lipids from peripheral to the center of the body, as well as reduces absorption in the intestine and increases secretion through the kidneys.

dexchlorpheniramine maleatamine is a propellamine derivative antihistamine. Dexchlorpheniramine inhibits the pharmacological effect of histamine (antagonistic substance with H1 histamine receptor).

pharmacokinetics

No report.

Before taking Colergis Dexa Silo treat allergies to be treated with corticosteroids (60ml)

How to use

oral medication.

Dosage

adults and children ≥ 12 years old

1 teaspoon full every 4 - 6 hours, no more than 6 teaspoons/day.

Children 6 - 12 years old

½ teaspoon every 4 - 6 hours, no more than 3 teaspoons/day.

2 - 6 years old: teaspoons every 4 - 6 hours, no more than 1.5 teaspoons/day.

For babies and children, the dosage will be more accurate when based on the reaction and the degree of disease rather than age, weight or body surface area. The drug should be used simultaneously with food or milk to reduce the side effects on the gastrointestinal tract.

Dosage depending on the condition and response of the patient, when the response is achieved, gradually reduce the dose to the lowest dose, sufficient to meet the clinical response permanently.

During long -term treatment, it is advisable to gradually reduce the medication. Before long -term treatment, patients should first make electrocardiograms, blood pressure, chest and spine X -rays, check the sugar and HPA axis function, as well as X -ray gastrointestinal disorders for patients who are prone to digestive disorders.

During long -term treatment, periodic assessment of height and weight of chest and spine X -ray should be evaluated, hematopoietic system, electrolyte, glucose tolerance, blood pressure and glaucoma.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Colergis you may experience some unwanted effects (ADR).

Common, ADR> 1/100

Nervous system: Sleep, headache, dizziness, weakness, mental disorders.

Digestive system: dry mouth, digestive disorders (anorexia, nausea, vomiting, constipation, diarrhea).

ENT: Nose and throat.

Metabolism: liquid and electrolyte balance disorders, HPA axis inhibitors.

Eye: glaucoma.

musculoskeletal system: muscle disease, loss of muscle mass.

Uncommon, 1/1000

No report.

Not determined frequency

Metabolism: adrenal shell atrophy and secondary adrenal insufficiency; increase sensitivity to infections, especially in high doses; edema, sodium hold, loss of potassium, alkaline infection; Hypotension and hypertension, hypocalcemia, endocrine disorders include energy and amenorrhea or other menstrual disorders; Reduce glucose intolerance, hyperglycemia and worsen diabetes.

Eyes: Causes cataract under the following bags, especially in children, eye pressure and glaucoma; Eye nerve destruction.

Digestive system: Effects on the gastrointestinal tract (nausea, vomiting, anorexia causing weight loss, increased cravings that cause weight gain, diarrhea, constipation, bloating, pancreatitis, stomach irritation and esophageal ulcer).

Nervous system: affects the nerves (dizziness, insomnia, restlessness, depression and anxiety).

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

contraindicated

Colergis drugs contraindicated in the following cases:

hypersensitivity to betamethasone and sulphite.

Patients are being treated with Monoamine Oxidase inhibitors (Maoi).

infants and premature babies.

Systemic fungal infection.

Patients in vaccination.

Peptic ulcer.

Be cautious when using

betamethasone can cause false negative results when testing Tetrazolium Nitroblue about systemic bacteria infection and prevent skin test reactions and as complications of reaction treatment with thyroid inflammatory drugs.

The use of drugs should be carefully performed in closed angle glaucoma, duodenal congestion, prostate hypertrophy or obstruction of the bladder neck, diabetes, steroid diseases and epilepsy. Using Colergis can prevent clinical symptoms of infection.

Long -term use can inhibit the immune system against infection. When used for a long time, avoid sudden stopping. The long -term use of corticosteroids can cause cataracts under the following, glaucoma with the ability to destroy optical nerves and may increase secondary eye infections caused by fungi and viruses. Be cautious in patients with congestive heart failure because Colergis can cause water retention.

Patients should be instructed by the doctor about the progression of infection, signs of infection (fever, sore throat, urinary pain, muscle pain) and wounds during treatment or 12 months after stopping treatment to adjust the dose and if re -management is necessary.

The use of drugs should be carefully done in the elderly, weakness, patients with hypothyroidism/cirrhosis, myocardial infarction, asthma, mental disorders, hypertension; Liver function failure, patients with myastheniastenic drugs, anti -cholinesterase drugs, vascular blood disorders, kidney failure, osteoporosis, herpes Simplex infection in the eye, glaucoma and convulsions disorders.

tends to osteoporosis, so the use of drugs in menopausal patients should be done carefully. Colergis must not be used for patients with peptic ulcer, except for very serious cases; Also, be careful in patients with excess inflammation, ulcerative colitis and intestinal connection.

It should not be used in the case of viruses/bacteria that cannot be controlled by antibiotics unless in a very endangered situation. Preventive treatment with chemicals should be applied in the management of patients with a history of tuberculosis.

Use for children: If possible, avoid high doses of prolonged doses for children, because Colergis can reduce the growth rate of bone; If you really need long -term treatment, always monitor babies and growth and development of children. High doses in children also cause acute pancreatitis, moreover also destroying the pancreatic gland.

The ability to drive and operate machinery

can reduce the ability to drive or operate machinery (drowsiness, dizziness, weakness).

Pregnancy

used during pregnancy can damage the fetus.

breastfeeding period

breastfeeding women use betamethasone should not breastfeed.

Drug interaction

barbiturat, phenytoin and rifampin (liver enzyme induction drugs) can increase the metabolism of betamethasone, so the dose adjustments need to simultaneously adjust these therapies.

Concentrated with ulcerative drugs such as indomethacin can reduce the risk of stomach/intestinal ulcers.

Concentrated with aspirin in patients with hypoglycemia should be done carefully. In patients with polyarthritis, simultaneous use with salicylate should be done carefully, always monitoring adverse effects.

Diuretics (Thiazide, Furosemide, Ethacrynic Acid) and other drugs that cause potassium loss causes excessive effects of betamethasone on potassium, therefore must always monitor serum potassium.

In patients with myasthenia gravis, it is recommended to stop using anti -cholinesterase drugs for at least 24 hours before starting to use betamethason. Vaccination in patients who are taking betamethasone needs a hypotenetic test to ensure appropriate antibodies and vaccines/toxins can increase.

Central nervous system weakness may be worse when used simultaneously with other depression, such as sedatives, sedatives and alcohol; Doctors should not give these drugs to avoid overdose and patients should be notified not to drink alcohol. Maoi can extend and exaggerate anti -histamine effects.

Storage

Temperature does not exceed 30 ° C.

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