Colthimus Hataphar medicine for muscle spasticity symptoms (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Tizanidine
Ingredient Cerebral vascular stroke, disc herniation, scattered sclerosis, brain injury, neuritis, crew, cerebral palsy, Lumbar pain, spinal cord, spinal injury, muscle spasticity

Ingredient

Composition information	Content
Tizanidine	4mg

Uses

indications

Colthimus drugs are indicated in the following cases:

Treatment of muscle spasticity caused by scattered sclerosis or spinal cord lesions. The main position at the spinal cord, stimulating the Alpha 2 receptor in the Synape Cash Region, inhibiting the release of amino acids that stimulate the N-methyl-D-ASPartat receptor (NMDA). Inhibiting multi -connection neuromuscular transmission at the spinal cord, which is a path of transmission, increases muscle tone, so the drug has the effect of inhibiting and reducing muscle tone. In addition, tizanidin also has a moderate central analgesic effect. Tizanidine is effective in the case of acute spasms as well as on chronic spasms of brain and spinal cord. Tizanidine reduces the resistance of passive movements, soothes convulsions and vibration, improves muscle active movements.

pharmacokinetic

absorption

tizanidin absorbs quickly, reaching the peak concentration about 1 hour after drinking.

Distribution

About 30% linked to plasma proteins and easily through the brain barrier.

Metabolism

tizanidin metabolizes mainly by the liver. In in vitro study, tizanidin is metabolized mainly by cytochrom P450 1A2.

Elimination

The active ingredient is not changed as well as the metabolites are eliminated mostly through the kidneys (about 70% of the dose). Tizanidine waste sale time is from 2 to 4 hours.

linear

tizanidine has linear pharmacokinetic within 4 mg to 20 mg.

Before taking Colthimus Hataphar medicine for muscle spasticity symptoms (10 blisters x 10 tablets)

How to use

Colthimus drugs for oral use, have a relatively short effect (maximum efficiency within 2-3 hours after taking the drug), so it must be taken several times a day (3-4 times/day). The time and frequency of the dose depends on the needs of the patient. Need to adjust the dose depending on the response of the patient.

Optimal treatment is usually achieved with a daily dose from 12 mg to 24 mg, used in 3 or 4 doses equal, the only dose must not exceed 12 mg. Total daily dose should not exceed 36 mg.

Cases of stopping treatment in patients with high doses for a long time, the dose should be gradually reduced.

Dosage

adults and people aged 18 and over

Muscle spasticity treatment

Normal starting dose: 2 mg/single dose.

After that, depending on the response of each patient, the dose may increase gradually 2 mg, at least 3-4 days apart, up to 24 mg/day divided into 3-4 times.

The maximum dose is 36 mg/day.

Treatment of pain caused by muscle contraction

Oral dose 4 mg/time, drink 1-3 times/day.

For people with renal failure with creatinine clearance

Starting dose 2 mg/time, 1 time/day.

then gradually increases until the desired effect is reached. Each increase does not exceed 2 mg. Should increase the dose 1 time/day before increasing the number of times a day. Must monitor kidney function.

Elderly

The usual dose is like young people. The dose can be adjusted because the renal clearance may be reduced 4 times compared to normal adults.

Children under 18 years old

has not determined the safety and effectiveness of the drug, so it is not used for these patients.

Patients with liver failure

Contraindications.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? Symptoms: nausea, vomiting, hypotension, heartbeat, dizziness, restlessness, anxiety, drowsiness, pupils, respiratory failure, coma.

Need to go to a medical facility to take appropriate measures such as washing the intestine, then using activated carbon and increasing the urology, respiratory and cardiovascular assistance. No specific antidote.

What to do when forgetting a dose? If the next dose time is taken, skip the forgotten dose. Do not use double dose to compensate for the forgotten dose.

Side Effects

When using Colthimus, you may experience unwanted effects (ADR).

Common, ADR> 1/100

digestive: dry mouth, abdominal pain, diarrhea, indigestion. skin.

Other: Fever, fatigue.

Cardiovascular: vasodilation, hypotension, fainting, migraine, arrhythmia. Weigh.

Central nervous system: Run, easy to emotion, convulsions, paralysis, thinking disorders, dizziness, dreaming, personality disorders, migraine, dizziness, peripheral neuritis. Eyes, optic neuritis, otitis media.

Cardiovascular disease: angina, coronary disorders, heart failure, myocardial infarction, venous inflammation, pulmonary embolism, ventricular extracellular, tachycardia. Kidney, hyperglycemia, hypokalemia, hypoglycemia, hypoglycemia. liver. Capacity:

The immune system: Hypersensitivity reaction.

Mental: anxiety, confusion. ADR

To minimize the unwanted effect of the drug such as drowsiness, fatigue, dizziness, dry mouth, nausea, digestive disorders and hypotension, it is necessary to start with low doses and then gradually increase to the effective dose of treatment that users still tolerate drugs. Rarely to stop the drug.

The illusion is all self, there is no manifestation of mental illness and often occurs when used simultaneously with antidepressants.

Transaminase temporarily increased, when stopping the drug will return to normal.

muscle weakness is sometimes notified but usually does not cause reduced muscle tone.

Need to reduce the dose slowly to avoid hypertension and tachycardia again.

Closely monitor the manifestation of blood pressure before increasing the dose to avoid the risk of hypotension. Be cautious when changing a sudden posture from lying or sitting to a upright posture.

For people with renal failure, it is necessary to closely monitor unwanted effects to avoid the risk of overdose and need to monitor the kidney function of drug users.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Colthimus drugs contraindicated in the following cases:

Severe liver failure.

Caution when using

on the cardiovascular system and blood pressure: The drug extends the QT range, causing slow heart rate. As well as alpha 2-adrenergic agreeders, tizanidine can cause hypotension. Hypotension effect depends on the dose and appears after single -dose use ≥ 2 mg. When changing a sudden posture may increase the risk of hypotension. Be cautious when using drugs for patients with cardiovascular disorders, coronary artery disease.

tizanidine can cause liver damage, so it is very careful for people to impaired liver function. Aminotransferase should be monitored in the first 6 months of taking the drug (at the time of the 1st, 3rd and 6), then periodically monitoring depends on dependence and clinical status.

When stopping the drug suddenly in patients with high doses and prolonged or used with antihypertensive drugs can cause hypertension, fast heart rate.

tizanidin can cause hallucinations in some drug users.

On the eyes: For experimental animals, medications that cause retinal degeneration and corneal opaque. However, there is no report on this effect in clinical studies.

On people with renal failure: Use careful drugs for kidney failure with creatinine clearance

Elderly: only tizanidine uses when they have considered their benefits higher than the risk because on the elderly, the renal clearance can decrease 4 times.

Children: Experience using tizanidin for children under 18 years old is very limited. So do not take medicine for children under 18 years old.

Due to the composition of lactose drugs, it is not used for people with congenital galactose, glucose and/or galactose or lactase -deficient syndrome (rare metabolic diseases).

The ability to drive and operate machinery

tizanidin has a sedative effect, can cause drowsiness, lower blood pressure, so it is necessary to be cautious for people who need alertness such as driving, operating machinery.

Pregnancy

tizanidin has not been studied on pregnant people. Should only use medication for pregnant people when really necessary.

Breastfeeding period

In animals, a small amount is excreted in milk. It has not yet been determined whether tizanidin is through breast milk or not. Tizanidine is soluble in lipids so it is likely that the drug can be added to breast milk, only use medication for nursing mothers when they have carefully considered the benefits higher than the risk of risk.

Medicinal interaction

Medications that cause hypotension: Tizanidin also lower blood pressure, so be cautious when used simultaneously with drugs that cause hypotension, including diuretic drugs. Also be cautious when taking tizanidin along with beta-adrenergic and digoxin inhibitors because of the risk of hypotension and heart rate.

CYP inhibitors: Increased tizanidine levels in plasma. Increase AUC 33 times and 10 times when using tizanidine with fluvoxamine, ciprofloxacin. When used simultaneously increases the effect of lowering blood pressure, drowsiness, dizziness, changing mental movement.

Do not coordinate tizanidin with anti -arrhyths (amiodaron, mexiletin, propafenon), cimetidin, some fluoroquinolon, rofecoxid, ticlopidin.

Oral contraceptives that reduce the clearance of tizanidine about 50% should increase the unwanted effect of tizanidin.

Alcohol increases the area under the concentration - time (AUC) curve of tizanidine by about 20%, increasing the peak concentration of about 15% thus increasing the unwanted effect of tizanidine. Tizanidine and wine inhibit the central nerve inhibitors.

Phenytoin: Tizanidine increases serum phenytoin concentration. When using these two drugs simultaneously, should monitor Phenytoin concentration to adjust the dose if needed.

acetaminophen: Tizanidin extends the time to reach the peak concentration of acetaminophen.

Storage

to be out of reach of children. Store drugs in dry places, temperatures below 30 ° C.

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