Combilipid MCT Peri Injection JW Pharmaceutical solution provides nutrients (375ml)

Mechanism of impact:

The purpose of nutrition on the gastrointestinal tract is to provide all the essential nutrients for tissue development and regeneration.

These are specially important amino acids because some of which are essential ingredients for protein synthesis. Concomitant use with energy supplies (carbohydrates/lipid) is necessary to avoid the use of the wrong energy of amino acids while still providing the process of energy consumption later.

Glucose is metabolized everywhere in the body. Some tissues and organs such as the central nervous system, bone marrow, tubular epithelium only use energy from glucose. Moreover, glucose acts as a frame of structure for many types of cell matter.

Due to the high density of energy, Lipid is an energy that provides energy efficiently and provides the body with the necessary fatty acids for the synthesis of cell components and prostaglandin. Because of this purpose, lipid emulsion contains medium -chain triglycerides and long chain (soybean oil). medium -chain triglycerides are hydrolyzed, excreted from circulation and is completely oxidized faster than long chain triglycerides. They are energy -providing substrates, especially when there is a disorder of decline and/or using long -chain triglycerides, for example, when there is a deficiency of lipoprotein lipase and/or a deficiency of lipoprotein lipase elements. Saturated fatty acids are only provided by long -chain triglycerides, which are firstly for the room and treat the necessary fatty acid deficiency and then provide energy.

Dynamic pharmacokinetics

Combilipid MCT Peri Injection is transmitted by intravenous lines, so all substrates are ready for immediate metabolism.

Amino acids that do not participate in the protein synthesis are metabolized as follows. The amino root is separated from the carbon frame by amino metabolism. Carbon chain is also directly oxidized into CO2, or used as a substrate for the new glucose in the liver. Amine base is also converted in the liver into urea.

Glucose is converted into CO2 and H2O in known metabolic lines. Part of the glucose is used for lipid synthesis.

When the instructions on the dose are followed, the medium -chain fatty acids and long -chain fatty acids do not pass through the brain blood barrier and therefore do not enter the cerebrospinal fluid.

There are no data related to the drug passing through the placenta and going into breast milk.

Dose, transmission speed, metabolic traits and specific characteristics of each patient (hunger level) are important factors that are decisive to achieve maximum triglycerides. When used in accordance with the instructions on the dose, generally triglyceride concentration does not exceed 3 mmol/l.

Children aged 14 and older and adults:

Maximum daily dose 40ml/kg body weight, equivalent to:

Children over 2 years:

The recommendation is given as a guide data based on average requirements. The dose should be adjusted accordingly according to age, development stage and disease. To calculate the dose must take into account the hydration of the child.

For children, it may be necessary to start adding nutrients at half a dose of adults. The dose should be slowly increased according to the metabolism of each patient to the dark dose.

Daily dose for children from 3-5 years old:

45 ml/kg body weight corresponds to:

30 ml/kg body weight, equivalent to:

Time of use:

This emulsion time does not exceed 7 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

symptoms:

will not overdose Combilipid MCT Peri Injection if used properly.

Symptoms of overdose of water and electrolytes: hypertonic water stasis, electrolyte imbalance and pulmonary edema.

Symptoms of amino acid overdose: A amino acid loss with the kidneys along with continuous amino acid imbalance, fatigue, vomiting and tremor.

Symptoms of glucose overdose: hyperglycemia, glucose in urine, dehydration, osmotic pressure, coma due to hyperglycemia and osmotic pressure.

Symptoms of lipid overdose: Lipid overdose can lead to overload symptoms, manifestations (eg) fever, headache, abdominal pain, fatigue, hyperlipidemia, enlarged liver with jaundice or non -jaundice, enlarged spleen, liver dysfunction, anemia, reduced blood cells, leukopenia, hemorrhagic and bloody, blood coagulation time, blood coagulation time, blood coagulation time, blood coagulation time, blood coagulation time, blood coagulation time, blood coagulation time, blood coagulation time, blood coagulation time ( prothrombin, ...). Plasma triglyceride concentration does not exceed 3 mmol/l during transmission.

Treatment, overdose: Immediately stop transmission is indicated for overdose. Additional treatments depend on their separate symptoms and severity. When the transmission is indicated after the symptoms have decreased, it is recommended that the transmission rate should be slowly increased by time control over time.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Due to the composition of Combilipid MCT Peri Injection should not be used for babies, children and children under 2 years old.

The general contraindications for nourishing the gastrointestinal tract are:

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Due to the individually indication of the pediatric patient, Combilipid MCT Peri Injection may not include enough total energy requirements. In this case, carbohydrate and/or lipid must be provided appropriately.

Should be cautious in case of increased serum osmotic pressure.

As with large volume transmission solutions, Combilipid MCT Peri Injection should be used carefully for patients with heart or kidney failure. Disorders of metabolism, electrolytes and base acid balance disorders (such as water stasis, hyperkalemia, acidic infection) should be adjusted before infusion of MCT Peri Injection. Too fast transmission can lead to epidemic overload with serum electrolyte concentration at pathological level, water stasis and pulmonary edema.

Serum triglyceride concentration should be checked when transmitting MCT Peri Injection Combilipid. The hemorrhage lipids should be checked when hungry in patients suspected of having lipid metabolic disorders before starting to transmit. The use of lipids is contraindicated if there is a lipid when hungry. The increase in blood triglycerides 12 hours after lipid also indicates disorders in lipid metabolism.

Combilipid MCT Peri Injection should be careful when transmitting patients with lipid metabolic disorders such as renal failure, diabetes, pancreatitis, liver failure, hypothyroidism (with hyperlemen blood glyceride) and infection. If transmitting Combilipid-MCT Peri Injection in the above cases, it is required to strictly control serum triglycerides.

Any signs or symptoms of hypersensitivity reactions (such as fever, tremor, rash or shortness of breath) must be used immediately.

Depends on the patient's metabolic conditions, in case of hyperemia of blood triglycerides or increased blood glucose levels may occur. If plasma triglyceride concentration increases above 3 mmol/l during lipid transmission, it is recommended that the transmission speed should be reduced. If plasma triglyceride concentration is over 3 mmol/l, it should be used until the concentration of triglyceride is normal.

Dosage or stop reduction is also indicated in the case of blood glucose levels higher than 14 mmol/l (250mg/dl) when transmitting products.

As all carbohydrate solutions, MCT Peri Injection Combilipid transmission can lead to hyperglycemia. Blood sugar levels should be controlled. Blood sugar increases, the transmission rate should be reduced or should be used with insulin. Intravenous transmission of amino acids occurs together with increased micronutrients elimination of micronutrients through urine, especially copper and zinc elements. Therefore, the dosage of special micronutrients should be considered in the case of long -term transmission nutrition.

Combilipid MCT Peri Injection is not transmitted with blood in the same fluid set due to the risk of fake red blood cells.

Moreover control electrolytes, water balance, acid-base balance and in the long-term use, it is necessary to count red blood cells, blood clotting and liver function are necessary.

Fat concentration can affect some test parameters (for example, bilirubin, lactate dehydrogenase, oxygen saturation) if the blood is sampled before the fat is excreted from the bloodstream.

Supplement electrolytes, vitamins and trace elements if necessary.

Because Combilipid MCT Peri Injection contains zinc, and magnesi, be careful when used with solutions containing these elements.

As all absolute sterile intravenous solutions are necessary when transmitting MCT Peri.

Combilipid MCT Peri Injection is a mixture of multiple components. Therefore it is strongly recommended that no other solutions are not added.

The effect of drugs on driving and operating machinery

does not affect.

Use drugs for women during pregnancy and lactation

Pregnant women:

There is no preclinical data on the use of Combilipid MCT Peri Injection for pregnant women. The prescription should pay attention to the relationship between the benefits/risks before the MCT Peri Injection Combilipid MCT.

breastfeeding women:

is recommended not to breastfeed if the mother needs to nourish the digestive tract during that time.

Interactive drug

Some drugs, such as insulin, can affect the body's lipase system. However, this type of interaction seems to be limited in clinical significance.

Using heparin at the dose of treatment causes slight release of lipoprotein lipase during circulation. This may initially increase the lipid resolution in plasma and then mitigate the clearing of triglycerides.

Soybean oil contains natural vitamin K1. This may affect the effectiveness of cumarin derivatives that should be closely tested in patients treated with these drugs.