Compound Sodium Lactate B.Braun solution supplement electrolytes (500ml)

Dosage form Bottle x 500ml
Specifications Sodium chloride, sodium lactate, potassium chloride, calcium chloride dihydrate
Ingredient Fever, diarrhea, anemia, hypoglycatry blood

Ingredient

Composition information	Content
Sodium chloride	3G
Sodium lactate	1.56g
Potassium Chloride	0.2g
Calcium chloride dihydrate	0.135g

Uses

Indications

Compound Sodium Lactate B.Braun is indicated in the following cases:

Alternative solution in the condition of disturbing acid-base balance or mild acidosis. Chemistry:

The solution consists of essential ions in extracellular fluids. Therefore, the pharmaceutical properties of the ions contained inside (Na, K, Ca, Cl, Lactate) are similar to normal physiology.

Lactate is the main substance in the intermediate metabolism. It is oxidized to form a bicarbonate, which has a slight alkaline effect.

Pharmaceutical impact:

The sodium lactate mixture has an electrolyte component similar to extracellular fluid (ignoring some very small differences). It is used to adjust the electrolyte imbalance and-acid-base in serum. The electrolyte is used to achieve or maintain normal osmotic pressure both inside and outside the cell. Due to its distribution in a solution that works in short hemodynamics.

Calculated by the proportion of metabolic anions, the sodium lactate mixture is specifically indicated for patients who tend to be acid.

pharmacokinetic

absorption

When the components of the sodium lactate mixture are transmitted into the vein, its bioavailability is 100%.

Distribution

The use of sodium lactate mixture helps fill the space between the space with an amount of about 2/3 of the extracellular volume. Only 1/3 of the concentration stays in the intravascular fluid. Therefore, the solution has a short hemodynamic effect.

Metabolism and elimination

Potassium, sodium and chlorine are metabolized mainly through urine but a small amount lost through skin and gastrointestinal tract. Specific surgical results show that the excretion through the urine of potassium while water and sodium are retained.

Calcium is eliminated mainly through kidney function. Small amounts are lost through skin, hair and nails. Calcium through the fetus and excreted into breast milk.

Lactate is converted into bicarbonate and CO2, both are common components of the body. The concentration of bicarbonate and lactate in plasma is adjusted by the kidneys and the concentration of CO2 is adjusted by the lungs. Lactate metabolism is impaired in state -of -the -end state of blood oxygen and liver failure.

Before taking Compound Sodium Lactate B.Braun solution supplement electrolytes (500ml)

How to use

Compound compound sodium lactate uses intravenous injection.

Dosage

Big and young people

Maximum daily dose up to 40 ml/kg weighs daily, equivalent to 5.24 mmolna/kg and maximum 0.22 mmolk/kg per day.

Maximum transmission speed:

The transmission speed should be controlled according to the patient's clinical condition.

Recommended doses for babies and children: 20 - 100 ml/kg weight per day, equivalent to 2.6 - 13 mmolna/kg and 1.108 - 0.54 mmolk/kg weight per day.

Maximum transmission speed: average is 5ml/kg weight per hour, but indicators change with age:

6 - 8 ml/kg Weight per hour for babies 1.

4 - 6 ml/kg Weight per hour for children to practice 1.

2 - 4 ml/kg Weight per hour for children to go to school 2.

1 newborn and children practice: ages from 28 days to 23 months.

2 children go to school: ages 2 to 11 years.

Elderly

Basically, the dose is similar to adult dose, but be cautious in patients who are suffering from diseases such as heart failure, kidney failure because they may occur often when they are old.

Patients with burns

To calculate the amount of fluid needed for patients with burns, according to Parkland the values can be used as instructions below:

Adults: Within the first 24 hours, the mixture of sodium lactate is used with 4 ml/kg of weight/% burns.

For children weighing from 0 - 10, the amount used is 4 ml/kg of weight/hour.

For children with weight from 10 - 20, the amount used is 40 ml/hour + 2 ml/kg weight/hour.

For children weighing more than 20 kg, the amount used is 60 ml/hour + 1 ml/kg weight/hour.

Transport solution: If the sodium lactate mixture is used as a transport solution for compatible drug products and electrolytes, the instructions will be related to the drug products used and must be monitored.

Replace short -term concentrations: To restore normal blood volume values, the concentration is approximately 3-5 times higher than the loss of blood.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Treatment: Discontinue transmission, use intercontinental diuretics to control electrolyte levels in serum, electrolyte correction and acid-base imbalance. Serious overdose can be filtered if necessary.

What to do when forgetting 1 dose?

No report.

Side Effects

When using Compound Sodium Lactate B.Braun, you may experience unwanted effects (ADR).

Unknown frequency

Disorders of metabolism and nutrition: Hypoglyc sodium.

Neurological disorders: Hypotenic sodium hypotension.

Hematropia disease can cause a traumatic brain injury and death due to progression of acute sodium -lowered sodium.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Compound Sodium Lactate B.Braun contraindicated in the following cases:

A decrease in the ability to use lactate accompanied by an increase in blood lactate.

Increase water: This situation is not indicated to treat severe metabolism of acidosis.

Related to lactate: The use of bicarbonate or bicarbonate precursor like lactate leads to urine alkalinity with increased fluid volume in the kidneys by acidic drugs (for example, salicylic acid). The sale time of basic drug preparations - especially sympathetic drugs (e.g. ephedrine, pseudoepherine) and stimulants (for example: dexamphetaminesulphate, fenfluramine hydrochloride) can be extended if the solution containing lactate containing simultaneously.

Increases the effects of vasopressin.

The drugs listed below increase the effects of vasopressin, leading to a reduction in the excretion of free electrolytes and may increase the risk of sodium lowering:

Liberation drugs of Vasopressin include: Chlorpropamide, Clofibrate, Carbamazepine, Vincistine, Serotonin Restrain inhibitors, 3.4-Methylenedioxy-N-Methamphetamine, Ifosfamide, Anti-Psychotic Pedagogs

The drug increases the effects of vasopressin including: chlorpropamide, NSAIDs, cyclophosphamide.

Similar substances vasopressin include: desmopressin, oxytocin, vasopressin, terliprein.

Other drug products that increase the risk of sodium hypoglycemia also include diuretics in general and anti -epileptic drugs such as oxacarbazepine.

Precautions when using

The solution should be used carefully in the following cases:

dehydration.

Hemorrhage.

Hemorrhagic hypercasses.

Hypercalcemia.

liver failure.

Hypercodia hyperka.

Large transmission should only be used under specific monitoring in patients with heart failure, kidney failure or pulmonary failure, brain edema, and in patients with non -osmotic vasopressin release (including SIADH), thus leading to the risk of hypoglycemia.

Patients with blood sodium lowering with non -osmotic vasopressin release (for example, emergency disease, pain, stress after surgery, infection, burns, CNS), patients with heart disease, liver, kidney and patients in contact with Vasopressin subjects at risk of acute sodium hypoglycemia.

Acute sodium hypoglycemia can lead to sodium hypoglycemia (cerebral edema) characterized by headache, nausea, seizures, coma and vomiting. Patients with cerebral edema are at risk of severe brain injury, unable to recover and life -threatening.

Children, women of reproductive age and patients with brain disabilities (for example, meningitis, intracranial bleeding, brainstorming and brain edema) have a particularly serious risk of brain swelling and life -threatening due to acute sodium hypoglycemia.

Lactate use may be impaired when lacking oxygen or liver failure.

Sodium lactate mixture contains a similar amount of potassium as the physiological concentration of potassium in the blood. However, it is not suitable for treating patients with severe potassium.

Because the solution contains metabolic ions (for example, lactate), it can cause metabolic alkaline infection. Therefore, the solution should be used carefully in patients with metabolic alkaline infections.

Scholareates containing sodium chloride should be used carefully in patients:

Heart failure, peripheral edema or increased extracellular volume.

Hypertension, impaired renal function, pre -eclampsia or about to occur, Aldosterone or other conditions or treatment (e.g. corticoids/steroids) are related to sodium holding. Solution containing potassium salt should be used cautiously in patients with heart disease, susceptible to hyperkalemia such as renal failure or adrenal insufficiency, acute dehydration, or destruction of tissue on a large scale with serious burns.

Because of the presence of calcium:

Need to take care to prevent vessel escape from intravenous injection.

Should be carefully used with patients with impaired renal function or the disease is related to increased vitamin D levels such as sarcoidosis. Therefore, the use of calcium -containing solution should be avoided in patients with nephrotic syndrome or a history of kidney syndrome.

Cases of blood transfusion simultaneously, the solution should be used with the same fluid.

Patients with chronic sodium hypoglycemia: To avoid adjusting the concentration of sodium too quickly in patients with chronic sodium hypoglycemia due to rapid increase in sodium concentration may in some rare cases leading to side effects on osmotic pressure, such as osmotic myelin decomposition syndrome.

Pediatric:

The solution should only be used in special cases such as new births under 3 months.

Used as transport solution.

Note: If this solution is used as a transport solution, it is necessary to provide the safety information of excipients by the corresponding manufacturer.

Clinical monitoring should include checking electrolytes in serum, acid-base balance and water balance.

Lactate concentration should be carefully monitored and if lactate accumulates during the infusion process, reducing the dose and speed of transmission or stop use.

In case of pressure infusion under pressure may be needed in an emergency, all when removed from plastic bags and arrangement of transmission lines before using the solution.

The ability to drive and operate machinery

does not affect.

Pregnancy

data on limited amount (less than 300 results from pregnant women) from the use of the composition of the sodium lactate mixture in pregnant women. Research in animals does not indicate or indirectly the harmful effects related to reproductive toxicity. All components of the sodium lactate mixture are naturally present in the body and their biological characteristics are known as the specified product.

Sodium lactate mixture should be used carefully for pregnant women during labor, especially sodium concentration if used in combination with oxytocin.

Be cautious in the case of pregnancy toxicity.

Breastfeeding period

Calcium is excreted through breast milk, but at the treatment dose of sodium lactate mixture does not affect infant/breastfed babies has been predicted. Therefore, the mixture of sodium lactate can be used during breastfeeding.

Drug interaction

Use sodium lactate mixture as prescribed and contraindicated is recommended not to increase the concentration of electrolytes in serum. In case of an increase in the concentration of electrolytes, other reasons for the following interactions should be considered.

Increase sodium: corticoids/steroids and carbenoxoline may be related to keeping sodium and water (with edema and hypertension).

Incidentally related to potassium: Suxamethium, potassium -saving diuretic (amilorid, spironolactone, triamteren, used alone or combined), Acei (for example, CagPril, Enalapril), Angiotensin II receptor inhibitors (for example: Valsartan, Losartan), Tacrolimus, cyclosporine can increase the level of dramatropic concentration in the drofest concentration. Leading to hidden hidden hyperkalemia is noticeable in the case of renal failure to increase the effect of potassium.

Regarding calcium

Digitalis glycosides (heart glycosides) may increase their effects in increased calcium and lead to severe or death arrhythmia.

Thiazide diuretics and vitamin D simultaneously used with calcium can cause hypercalcemia: If biphosphonates, flourides, some flouroquinolones and tetracyclin are simultaneously used with calcium -containing solutions, biochemical (reducing absorption) of drug products may be reduced.

Storage

Store temperatures below 300C.

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