Concor 5mg Merck treatment for hypertension, angina (3 blisters x 10 tablets)
Dosage form Box of 3 blisters x 10 tablets
Specifications Bisoprolol
Ingredient Coronary artery disease, heart failure, high blood pressure
Ingredient
| Composition information | Content |
| Bisoprolol | 5mg |
Uses
Indications
Concor medicine 5mg is indicated in the following cases:
Therefore, bisoprolol generally does not contain the impedance of airway impedance and effects on metabolism through the receptor intermediaries β2. Selective characteristics on beta 1 of the drug still exists with a dose beyond the treatment dose.
pharmacokinetic
absorption
Bisoprolol is absorbed almost entirely from the digestive tract (90%) and because only a small amount of about 10% through initial metabolism, its bioavailability reaches about 90% after drinking. Bisoprolol's bioavailability is not affected by food. Bisoprolol's plasma performance and plasma concentration shows that proportional to the dose in the dose range from 5 to 20mg. Plasma peak concentration is achieved within 2-3 hours.
Distribution
Bisoprolol is widely distributed. The distribution volume is 3.5L/kg. About 30% close to plasma protein.
Metabolism
Bisoprolol is metabolized through the oxidation path without the conjugate afterwards. All polarized metabolites are eliminated through the kidneys. Main metabolites in plasma and urine do not work. In vitro testing on human liver microsom shows that bisoprolol is metabolized mainly through CYP3A4 (~ 95 %) and a small part via CYP2D6.
Elimination
Bisoprolol's clearance has a balance between the excretion of the kidneys in the form of constant form (50%). Metabolizes through the liver (SOBB) and is finally eliminated through the kidneys. The total bar of bisoprolol is about 15L/h. Selling time from 10 to 12 hours.
Before taking Concor 5mg Merck treatment for hypertension, angina (3 blisters x 10 tablets)
How to use
Concor 5mg should be used in the morning, with or not with food. Swallowing the whole pill with water, not chewed.
Dosage
Treatment of hypertension and coronary disease
In all cases, the dose will be adjusted for each patient, especially based on heart rate and treatment results. The normal starting dose is 5mg Bisoprolol (1 CONCOR 5MG) once/day.
In the case of mild hypertension (diastolic blood pressure up to 105mmHg) can be treated with 2.5mg per day/day is sufficient. If necessary, can it be increased to 10mg of bisoprolol (2 concorges 5mg) once a day. The maximum recommended dose is 20mg of bisoprolol once a day.
Treatment of stable chronic heart failure
Chronic heart failure treatment regimen includes enzyme inhibitors (ACE) (or angiotensin receptor blockers in the event of no tolerance of enzyme inhibitors), beta blockers, diuretics and with heart glycosides when appropriate. Before the treatment of the heart failure is stable with the 5mg Concor, it is necessary to have a special examination stage and need to be monitored regularly by the doctor.
Conditions before treatment with bisoprolol heart failure are stable without acute heart failure.
The treatment doctor needs experience in the treatment of chronic heart failure. Treatment of stable chronic heart failure with bisoprolol is started according to the standard regimen below, the response of each patient may depend on the patient's tolerance for each dose, which means that the dose is only tolerated before the previous dose.
The maximum recommended dose is 10mg of bisoprolol once a day. Patients should be monitored and maintained at this dose unless they cannot be due to side effects. It is necessary to closely monitor the signs of survival (blood pressure, heart rate) and signs of severe heart failure during the dose adjustment stage.
Change of treatment
During the dose or then, if the heart failure is severe, hypotension or slow heart rate, recommend to reconsider the dose of the medications being used simultaneously. Reducing Bisoprolol dose temporarily or considering the discontinuation of Bisoprolol treatment as needed. Always consider to start using bisoprolol or increase the dose when the patient is stable again.
Treatment time for all indications
Treatment with 5mg concorges is usually long -term treatment. The treatment may stop when needed and reuse when appropriate.
Do not stop treating suddenly or changing the dose without consulting the doctor because this can temporarily worse the heart. Do not stop treating suddenly. If it is necessary to stop treating, the dose should be slowly reduced.
Special cases
kidney failure or liver failure
Treatment of hypertension or coronary artery disease: No dose adjustment for patients with liver or kidney function mild to medium level. For patients with severe renal failure (creatinine clearance Treatment of stable chronic heart failure: There is no information on Bisoprolol's pharmacokinetics in patients with chronic heart failure or kidney failure. Determination of these cases is very cautious.
Older people
No dose adjustment.
Children
There is no sufficient experience in using bisoprolol for children, so it is not recommended to use 5mg concorges for children.
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.
What to do when overdose? In case of an overdose of the 5mg Concor, immediately notify the doctor. Depending on the level of overdose, the doctor will determine the treatment. The harmful effects of overdose may vary in each person and are very sensitive to patients with heart failure.
In general, when overdose should stop bisoprolol and conduct supportive treatment and symptoms. The limitations show that Bisoprolol is difficult to be fecal.
What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.
Side Effects
When using the 5mg concorist, you may experience unwanted effects (ADR).
Very common (≥10%), common (≥ 1%and 0.1%and
Testing
Heart disorders
Disorders in the nervous system
Eye disorders
Very rare: conjunctivitis.
Disorders of ear and inner ears
Respiratory, chest and mediastinum disorders
Digestive disorders
Skin and subcutaneous tissue disorders
Disorders of skeletal muscle and connective tissue
Pleetal disorders
Other disorders
Uncommon: Asthma (in patients with blood pressure or angina).
Liver disorders
Reproductive and breast disorders
Mental disorders
For hypertension or coronary artery disease
*These symptoms often occur when starting treatment. They are usually mild and disappear after 1-2 weeks of treatment.
Instructions on how to handle ADR
Notice immediately to the doctor the unwanted effects occur when using the drug. To prevent serious effects, immediately notify the doctor when the effect is serious, unexpectedly occurring or becoming heavier.
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
Contraindicated
Concor medicine 5mg contraindicated in the following cases:
Acute heart failure or stages of loss of loss of heart failure need intravenous injection of myocardial drugs.
Shock due to heart dysfunction (shock due to heart).
Serious atrial conduction disorders (atrial atrial clog II or III) without a pacemaker.
Sinus node impairment syndrome.
Atrial sinus block.
Slow heart rate, causing physical symptoms.
Low pressure, causing physical symptoms.
Heavy bronchial asthma.
The severe form of peripheral artery disease or Raynaud's syndrome.
Untreated kidney tumor (chrome cell tumor).
Metabolic acidosis.
Hypersensitivity to bisoprolol or any ingredients of the drug.
Precautions when using
Concor 5mg drugs must be used in the following cases:
Diabetes with abnormal changes in blood sugar: The obvious symptoms of hypoglycemic symptoms such as fast, thrilling or sweating may be hidden.
Strict fasting.
Are allergic treatment.
Mild atrial atrial transmission (atrial atrial block I).
blood flow disorders in coronary artery disease (prinzmetal angina).
Peripheral artery blockage (the disease may increase especially at the beginning of treatment).
Psoriasis patients with psoriasis or a history of psoriasis.
Respiratory system
Although the selected beta blockers on the heart (beta 1) may have less impact on the lung function than the unsatisfactory beta blockers, as well as for all beta blockers, avoid using these drugs in patients with airway obstruction, unless there are clinical reasons to be used.
If these reasons exist, the 5mg concorist can be used carefully. Cases of bronchial asthma or chronic obstructive pulmonary disease, which may cause symptoms, should be treated at the same time. Sometimes, an increase in airway resistance in asthma patients, so if stimulating beta 2 may have to increase.
allergic reactions
The β blockers, including the 5mg Concor, can increase the sensitivity of allergens and the severity of the reactions that are too satisfactory due to the opposite sympathetic regulation under the β blockade effect. Treatment with Adrenalin does not always bring the desired treatment effect.
Body anesthesia
In the case of patients with general anesthesia, using β blockers helps reduce the risk of arrhythmia and myocardial ischemia during the stage of narrative, intubation and postoperative stage. Currently, it is recommended to maintain β blockers in the period of surgery.
The anesthetic doctor must be notified in case the patient needs anesthesia to use β blockers due to the risk of interacting with other drugs, slow heart rate, reduce heart rate reflexes and reduce reflexes to compensate for blood loss. If it is necessary to stop using β blockers before surgery, gradually reduce the dose and end 48 hours before anesthesia.Chrome -preferred cells
In patients with adrenal tumors (chrome cell tumors), only 5mg concocor should only be used after blockade of receptors α.
thyroid poisoning
When treated with 5mg Concor symptoms of thyroid function (thyroid poisoning) may be hidden.
Special cases
So far, there is no sufficient experience in using the 5mg Concor for patients with heart failure with diabetes in insulin dependence, severe renal function, severe liver function, limited cardiomyopathy, congenital heart disease or physical valuable heart disease related to hemodynamics. There is no sufficient experience for patients with mild heart failure (Nyhaii) as well as heart failure and myocardial infarction for the previous 3 months.
The ability to drive and operate machinery
studies in coronary coronary patients show that Bisoprolol does not affect the patient's driving ability. However, due to the different reaction in each individual, the ability to drive and operate machines may be affected.
Need to pay attention to this possibility when starting treatment, when changing the dose as well as when drinking alcohol.
Pregnancy
During pregnancy, only 5mg concorges after the doctor have carefully considered the benefits and risks that may occur in general, β blockers reduce the amount of placenta and can affect the development of the fetus. Need to monitor the amount of placenta, uterus and fetal development in case of harm to the mother or fetus, it is necessary to consider changing the treatment method.
Breastfeeding period
Newborn should be monitored immediately after birth. Symptoms of hypoglycemia and slow heartbeat usually occur within the first 3 days. There is no data on Bisoprolol's excretion ability in human milk or the safety of bisoprolol for children's emulsion. Therefore, do not only use the 5mg concorist for nursing women.
Drug interaction
The effect and tolerance of the drug may be affected when used simultaneously. The interactions can occur when this drug is used immediately after another.
Notify your doctor if you are taking a certain drug, even non -prescribing drugs.
Combine should not be used
Treatment of stable chronic heart failure: Anti -arrhythmia group I (such as Quinidin, Disopyramid, Lidocaine, Phenytoin, Fiecainid, Propafenon) may increase the inhibition effect of Concor 5mg on the transmission of the atrial pulse and the heart spasm.
For all indications: Verapamil and diltiazem antagonists can reduce the heart muscle spasm and slow down the atrial impulse transmission when used with the 5mg concocor. Especially when the Verapamil intravenous injection for patients being treated with β blockers can cause strong hypotension and atrioventricular block.
Hematopsotic drugs have a central effect (such as clonidin, methyldopa, moxonodin, rilmenidin) that can reduce heart rate and cardiac arc as well as vasodilation due to decreased central sympathetic force. Stop using the drug suddenly, especially before stopping using β blockers may increase the risk of "corresponding hypertension*.
Combine must be cautious
Treatment of hypertension and coronary artery disease: Group I anti -arrhyths (such as quinidine, disopyramid, lidocaine, phenytoin, flecainid, propafenon) can increase the inhibition effect of concorphic 5mg on the transmission of the atrial pulse and the heart spasm.
For all indications
Dihydropyridine calcium antagonists (such as nifedipm) may increase the risk of hypotension when used with 5mg concorges. Do not eliminate the risk of rhetorical discharge of ventricular pump function in patients with heart failure.
Anti -arrhythmia group III (such as Amiodaron) may increase the inhibition effect of the 5mg concocor on the atrial pulse transmission.
Local β blockers (such as glaucoma eye drops) may have a combination of energy into the whole body effect of the 5mg concorist. Patrol drugs can increase the inhibitory effect on the transmission of the atrial pulse and the risk of slow heart rate when used with the 5mg Concor.
The effect of reducing the blood glucose of insulin and oral diabetes can be increased. Warning signs of hypoglycemia - especially an increase in heart rate - may be hidden or eliminated. These interactions often occur with non -selective chen.
Anesthesia may increase the risk of heart -inhibiting the heart of the concocor 5mg, leading to hypotension (if you need more information about general anesthesia, see the warning and caution).
Timoside (digitalis) can increase the time of impulse transmission and thus reduces the heart rate when used with the 5mg Concor.
Non -steroid anti -inflammatory drugs (NSAIDs) may reduce the hypotension effect of concoct 5mg.
Sympathetic enhancers β (such as isoprenalin, dobutamin) used with the 5mg Concor may reduce the effect of both.
The combination of 5mg concorists and active sympathetic enhancement both The β and α (such as noradrenalin, adrenalin) may increase the indirect vascular effect through the α receptor of these drugs that increases blood pressure and is more severe than they lame. These interactions are often out of unstable β blockers.
Medicines to treat hypertension as well as other drugs that are likely to lower blood pressure (such as three -round antidepressants, barbiturates, phenothiazin) may increase the hypotension effect of the 5mg Concor.
Combining to consider
Mefloquine may increase the risk of slow heart rate if used in combination with the 5mg Concor.
Monoamine oxidase inhibitors (except IMAO - B) may increase the hypotension effect of β blockers. However, use at the same time may also have a sudden risk of hypertension.
rifampicin: can reduce the half -life of bisoprolol due to stimulating the liver metabolic enzyme.
Usually not necessary to adjust the dose
Ergotamine conduction: Increased peripheral circulatory disorders.
Storage
The shop does not exceed 30 ° C.
Other drugs
- Controloc Control
- CO-AMOXICLAV 625MG TABLETS
- DECA-DURABOLIN 50MG/ML INJECTION
- Grastofil
- Mixtard
- MYPAID 120MG SR TABLETS
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Popular Keywords
- metformin obat apa
- alahan panjang
- glimepiride obat apa
- takikardia adalah
- erau ernie
- pradiabetes
- besar88
- atrofi adalah
- kutu anjing
- trakeostomi
- mayzent pi
- enbrel auto injector not working
- enbrel interactions
- lenvima life expectancy
- leqvio pi
- what is lenvima
- lenvima pi
- empagliflozin-linagliptin
- encourage foundation for enbrel
- qulipta drug interactions