Conoges 200 Boston drugs treat symptoms of osteoarthritis, rheumatoid arthritis (30 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Celecoxib
Ingredient Dysmenorrhea, colon polyps, rectal polyps, joint spondylitis, arthritis, rheumatoid arthritis, osteoarthritis

Ingredient

Composition information	Content
Celecoxib	200mg

Uses

Treatment of osteoarthritis symptoms, rheumatoid arthritis in adults.

Acute pain treatment, including pain after surgery, tooth extraction.

Treatment of Phat Nguyen Phat.

Advanced treatment to reduce the number of polyps in conventional therapy to treat family -type polyps.

Before taking Conoges 200 Boston drugs treat symptoms of osteoarthritis, rheumatoid arthritis (30 tablets)

How to use

In the treatment of osteoarthritis: Take one time or divided into 2 times equal, all have the same effect.

For rheumatoid arthritis: Should use the dose divided into 2 times.

For a dose of up to 200 mg/time, drink twice a day, can be taken with food or not.

For a dose of up to 400 mg/time, drink twice a day, take it at meals (with food).

Dosage

Bone degeneration - joints: Normal dose 200 mg/day, 1 time or divided into 2 equal doses.

rheumatoid arthritis: 100 - 200 mg x 2 times/day.

A joint spondylitis: 200 mg/day or 100 mg x 2 times/day.

Polyps - Rectal: 400 mg/time, taken 2 times a day.

Pain in general and menstruation: The usual dose in adults 400 mg/day/time, followed by 200 mg if necessary, on the first day. To continue analgesic, the dose of 200 mg can be used, taken 2 times a day, if necessary.

What to do when overdose?

can cause fidelity, drowsiness, nausea, vomiting and epigastric pain; These manifestations are often recovered with supportive treatment.

Gastrointestinal bleeding.

Symptoms occur rarely than hypertension, acute renal failure, respiratory inhibition and coma.

Management:

Treatment of nonsteroidal anti -inflammatory drugs including symptomatic and supportive treatment; There is no specific antidote for nonsteroidal anti -inflammatory drugs.

In the first 4 hours after overdose, vomiting therapy and/or activated carbon (60 - 100g for adults, or 1 to 2 g/kg for children), and/or an osmotic bleach may be useful for patients who have gone pathology or take a large amount of drugs.

whether Celecoxib does not have a hemorrhage, but the drug is attached to protein at a high rate of suggesting the use of forced urinary tract measures, urine alkalization, hemorrhage or blood transfusion may not be effective to remove large amounts of Celecoxib from the body.

What to do if you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

The unwanted effect of Celecoxib at the common doses is generally light and related to the digestive tract. The unwanted effects that make the most medication stop include: indigestion, abdominal pain. About 7.1% of patients using Celecoxib must stop taking the drug because of unwanted effects compared to 6.1% of patients who use Placebo to stop.

Common, ADR> 1/100

Digestive: abdominal pain, diarrhea, indigestion, flatulence, nausea.

Respiratory: Sore throat, rhinitis, sinusitis, upper respiratory infection.

Central nervous system: Insomnia, dizziness, headache.

DA: Ban. general: back pain, peripheral edema.

Rare, ADR

Cardiovascular: fainting, congestive heart failure, ventricular vibration, pulmonary disease, stroke, peripheral mail, thrombosis, vasculitis.

digestive: intestinal obstruction, intestinal perforation, gastrointestinal bleeding, bleeding colitis, esophagus, pancreatitis.

liver: gallstones, hepatitis, jaundice, liver failure. Hematology: reduces platelet amount, granulocytosis, non -regenerated anemia, reduces all bloody, leukopenia.

Metabolism: Hemorrhage reduction.

Central nervous system: loss of air conditioning, suicide paranoia. kidney: Acute renal failure, interstitial nephritis. skin: Diverse erythema, peeling dermatitis, Stevens - Johnson syndrome.

General: infection, sudden death, anaphylactic reaction, angioedema.

Notify the doctor with unwanted effects when using the drug.

Warnings

Precautions when using

Caution to use Celecoxib:

For people with a history of stomach ulcer, duodenal, or gastrointestinal bleeding, although the drug is considered to not cause digestive tract complications due to selective inhibition of COX - 2.

For the elderly, weakened because it is easy to cause gastrointestinal bleeding and often the renal function is impaired.

For people with heart failure, liver failure, kidney failure. Celecoxib can be toxic to the kidneys, especially when maintaining the blood flow through the kidneys requires the support of the kidney prostaglandin.

For people with edema, water retention (such as heart failure, kidneys) because of drugs that cause stasis, worse disease.

For people with foreign cell loss (due to strong diuretics). It is necessary to treat dehydration before using Celecoxib.

Because it is unclear whether Celecoxib will reduce the risk of Dai - Rectal cancer associated with general -rectal polyps or a family nature, so it is still necessary to take care of this patient as usual, which means that the endoscopy must be monitored, the outfit of the backup when needed. In addition, it is necessary to monitor the risk of cardiovascular complications (myocardial infarction, ischemic myocardial ischemia). Celecoxib has no intrinsic activity of platelet resistance and thus protects complications due to myocardial ischemia, especially if the high doses are prolonged (400 - 800 mg/day).

Pregnant and lactating women

pregnancy

There is no complete studies on Celecoxib in pregnant women. Pregnant women should only be used when the benefit is higher than the risk that may occur for the fetus. Do not use Celecoxib in the last 3 months of pregnancy, as Prostaglandin synthesis inhibitors may have a bad effect on the cardiovascular system of the fetus.

Breastfeeding period

It is not known whether Celecoxib is distributed into breast milk or not. Because Celecoxib may have serious unwanted effects in breastfed children, consider gums/harms or stop breastfeeding, or stop using Celecoxib.

driving and operating machinery

After taking the patient's medicine, the patient may be dizzy, so be cautious when driving and operating machinery.

Drug interaction

General: Metabolism of Celecoxib via cytochrom P4502C9 intermediaries in the liver. Celecoxib simultaneous use with drugs that inhibit this enzyme can affect the pharmacokinetics of Celecoxib, so be careful when using these drugs simultaneously. In addition, Celecoxib also inhibits Cytochrom P4502D6 space. Therefore, the interaction between Celecoxib and drugs is metabolized by P4502D6.

Angiotensin transferring enzyme inhibitors: Steroid anti -inflammatory drugs can reduce the anti -hypertension effect of angiotensin transferring enzyme inhibitors.

Diuretics: Non -steroid anti -inflammatory drugs can reduce the effect of increasing the excretion of furosemid and thiazide sodium in some patients, possibly due to the inhibition of prostaglandin synthesis and the risk of renal failure can increase.

Aspirin: Although Celecoxib can be used with low doses of Aspirin, simultaneous use of these two drugs can lead to an increase in the rate of gastrointestinal ulcers or other complications, compared to separate Celecoxib.

Fluconazole: Celecoxib simultaneous use with fluconazole can lead to significant increase in plasma concentrations of Celecoxib.

lithium: Celecoxib can reduce the litheur's kidney removal, which leads to an increase in lithium concentration in plasma. Warfarin: Bleeding complications combined with increased prothrombin time occurred in some patients (mainly elderly people) when using Celecoxib simultaneously with Warfarin.

Storage

In a dry place, temperatures below 30 ° C, avoid light.

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