Coperil Plus 4mg DHG drug treatment for primary hypertension (30 tablets)

Dosage form Box of 1 blister x 30 tablets
Specifications Indapamide, perindopril
Ingredient Hau Giang Pharmaceutical Joint Stock Company

Ingredient

Composition information	Content
Indapamide	1.25mg
Perindopril	4mg

Uses

Indications

Coperil Plus drug indicated in case of primary hypertension for uncontrolled blood pressure subjects with mono -treatment.

Pharmacological

Perindopril component in Coperil Plus is an angiotensin conversion enzyme inhibitor (Ace: Angiotensin Converting enzymes), which works through the activity of Perindoprilat metabolites.

Perindopril prevents Angiotensin I transforming into angiotensin II is a strong vascular contraction agent. Ace inhibition reduces angiotensin II in plasma, leading to increased activation of lenin in plasma and leads to reduced secretion of aldosteron secretion, which reduces sodium retention and increases potassium retention in the body.

Because ACE is inactivating Bradykinin, ACE inhibits also leads to the increase in the activity of the kallikrein-kinin system during the circulation and thus activating the prostaglandin system, this mechanism also contributes to lowering blood pressure. In hypertension people, Perindopril reduces blood pressure by reducing the peripheral resistance. The drug often causes artery dilatation and maybe even veins.

indapamid is a diuretic sulfonamid. Indopamid has diuretic and anti -hypertension effects.

Sodium ion reorganizing inhibitors in the dilute segment of the distance, increasing the excretion of sodium and chloride, thus increasing the urology. Indopamid is a response to blood vessels for vascular tonsils back to normal, reducing the pagan artery resistance.

The drug still maintains the effect of anti -hypertension in patients who have no kidney function.

Dynamic pharmacokinetics

The drug is absorbed quickly after taken. Strong metabolic drugs, mainly in the liver.

Perindopril converts into Perindoprilat that is active, food reduces biological transformation into Perindoprilat and thus reduces bioavailability.

The drug is excreted mainly in urine. Hematopathy does not eliminate indapamid from circulation.

Before taking Coperil Plus 4mg DHG drug treatment for primary hypertension (30 tablets)

How to use

Coperil Plus drug tutorial: This drug is usually given once in the morning, before meals.

Dosage

Dosage in hypertension: Use a dose of 1 Coperil Plus tablet per day (Perindopril 4 mg/indapamid 1.25 mg).

kidney failure:

Creatinin clearance> 60 ml/ min: No dose adjustment. Elderly patients: The starting dose should be adjusted depending on the response of blood pressure, especially when there is a loss of salt and water, to avoid the sudden start of the hypotension.

Symptoms: electrolyte disorders, hypotension, muscle weakness, digestive disorders, nausea, vomiting, respiratory failure. Treatment of support for maintenance of respiratory and circulatory functions.

Symptoms associated with hypotension. Conducting the fertilizer (70 ml/min) can remove Perindopril from the blood.

What to do when forgetting the dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Coperil Plus, you may experience unwanted effects (ADR).

Related to Perindopril: headache, temperament disorders and/ or sleep, weakness; Disorders of taste, dizziness, cramps; skin rash; irritated cough; helpless, dry mouth; mitigate hemoglobin; hyperboly blood; Feng shift on the face, head, lips, tongue, bar and/ or larynx.

Regarding indapamid: electrolyte disorders, hypokalemia, hypoglycemia or alkaline infection due to hypoglycemia; fatigue, muscle weakness; headache, dizziness, dizziness; Anorexia, nausea, vomiting; Lower blood pressure standing, hitting chest drums; rash, rashes, urticaria; thrombocytopenia, grain leukemia; SUPPLY SECURITY, cramps.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Coperil Plus drug contraindicated in the following cases:

Hypersensitivity to Perindopril, Indapamid and Sulfonamid conductors. Research in children should be contraindicated for children.

Be cautious when using

related to Perindopril:

Be cautious when taking the drug for patients with the following risk:

In case of heart failure, salt loss, risk of hypotension and/or kidney failure, kidney stenosis

Related to indapamid:

Be cautious when taking drugs in people with severe kidney disease, patients with impaired liver function or progressive liver disease, patients with hyperthyroidism or thyroid diseases, patients with surgery to remove sympathetic nerve.

periodically determine blood sugar levels, especially in patients who have been or suspected of diabetes.

The effect of the drug on driving and operating machinery

Caution when used because the drug can cause headaches, dizziness.

Use drugs for pregnant and lactating women

Do not use drugs for pregnant and lactating women.

Interactive drug

Non -steroid anti -inflammatory, corticoid, tetracosactid drugs reduce the effect of Perindopril.

Perindopril's lowering effects may become excessive when using diuretics before.

Collaborate with sedative and anti -depression drugs Imipramin will increase the risk of hypotension.

Perindopril increases the hypoglycemic effect of insulin and hypoglycemic oral medication.

Combining Perindopril with diuretics holding potassium and potassium salts at risk of hyperkalemia, especially in people with kidney failure.

combination of lithium and perindopril increases blood lithium.

Do not combine indapamid with other diuretic medications because it can cause hypokalemia and hyperuricemia. Do not use with lithium because of the risk of lithium poisoning. The indepamid reduces the artery response to vasoconstrictor like Noradrenalin, but is not enough to prevent the effect of noradrenalin.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

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