Corbis 5mg Efrroze medicine for hypertension, angina (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Bisoprolol
Ingredient Esophageal ulcer, heart failure, high blood pressure, fast heartbeat

Ingredient

Composition information	Content
Bisoprolol	5mg

Uses

Indications

Corbis 5 mg Efroze 2x10 medicine is indicated in the following cases:

Treatment of hypertension and angina. Due to the selected block of the Beta1 Adrenergic receptor but there is no membrane stability and has no effect of the intrinsic sympathetic nerve when used within the treatment dose range. With low doses, Bisoprolol selectively inhibits the response to sympathetic stimuli by competing for the receptor of Beta1 - Adrenergic receptors in the heart, but has little effect on the beta2 adrenergic receptor in the blood vessel and bronchial muscles. With high doses (≥ 20 mg), the selective properties of bisoprolol on beta receptors usually decrease and the drug will compete inhibiting both beta1 and beta2 adrenergic receptors.

Bisoprolol is used to treat hypertension. Bisoprolol's effectiveness is equivalent to other beta blockers. The mechanism of lowering the hypotension of Bisoprolol may include the following factors: reducing heart flow, renal inhibition releases renin and reducing the impact of sympathetic nerve from vasomotor centers in the brain. But the most prominent effect of Bisoprolol is to reduce the heart frequency, both resting and at exertion. Bisoprolol reduces the flow of the heart at a break and when exertion, accompanied by a few changes in the volume of blood expanding in every heart, and the limb increases the right atrial pressure or the pulmonary capillary pressure at the time of rest and exertion.

Unless there is a contraindication or an intolerant, beta blockers have been used in combination with enzyme inhibitors, diuretic and heart glycosides to treat heart failure due to left ventricular dysplasia, to reduce progressive heart failure. The good effect of beta blockers in the treatment of congested heart failure is mainly due to inhibition of the effects of sympathetic nervous system. Using long -term beta blockers, as well as transferred inhibitors, can reduce heart failure symptoms and improve the clinical condition of people with chronic heart failure. These good effects have been shown in people who are taking a transferred inhibitor, showing the inhibition of the coordination of the Renin-Anotensin system and the sympathetic nervous system are plus effects.

pharmacokinetic

absorption

Corbis 5 mg Efroze 2x10 tablets are absorbed and 90% after drinking. The sale time is 10 - 12 hours after the single dose for 24 hours.

Distribution

The ability to bind to plasma proteins of Bisoprolol Fumarat is 30%. The distribution volume is 3.5 l/kg.

Elimination

Bisoprolol Fumarat is eliminated in two roads. 50% is metabolized through the liver in the form of non -active metabolites and then eliminated through the kidney. 50% are eliminated through the kidneys in non -metabolic form. The total number of clearance is about 15 l/h.

In the elderly, the sale time in plasma is slightly longer than young people, although the average plasma concentration in a stable state increases, but there is no significant difference in the accumulation of bisoprolol between young people and the elderly.

In people with creatinine clearance ratio below 40 ml/minute, the semi -disposal time in plasma increases about 3 times higher than normal people.

In people with cirrhosis, the rate of excretion of Bisoprolol changes more and lower is significant than normal people (8.3 - 21.7 hours).

Before taking Corbis 5mg Efrroze medicine for hypertension, angina (2 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

Adults

Treatment of hypertension and angina in adults

The first usual dose is 2.5 - 5 mg, once a day. Because of the selection of blockers - 1 - Adrenergic of Bisoprolol Fumarat is not absolutely absolutely (selection decreases when increasing the dose), caution must be used for patients with bronchospasm, and start treatment at a dose of 2.5 mg, once a day. The starting dose can also be suitable for other patients. If the dose of 5 mg is not effective, it may increase the dose to 10 mg, and then, if necessary, it may gradually increase the dose to be tolerated to a maximum of 20 mg, once a day.

Treatment of stable chronic heart failure

Patients with chronic heart failure must be stable, there is no exacerbation within 6 weeks and must be treated with an enzyme inhibitor transferred to the appropriate dose (or with another vasodilator in case of non -tolerance of transferred inhibitors) and a diuretic, and/or sometimes with a digital, before bisoprolol treatment. Treatment has not changed much in the last 2 weeks before taking Bisoprolol Fumarat.

The treatment must be monitored by a cardiologist. Treatment of stable chronic heart failure with Corbis 5 mg Efroze 2x10 tablets must start with a dose adjustment period, the dose is gradually increasing according to the following diagram:

1.25 mg/day (taken in the morning) for 1 week. If tolerated, increased the dose.

2.5 mg/1 time/day for 1 week, if tolerated well, increase.

5 mg/day for 4 weeks later; If tolerated well, increase.

7.5 mg/day/day for 4 weeks later; If tolerated well, increase.

10 mg/day for maintenance treatment.

After starting the first dose of 1.25 mg, the patient must be monitored within 4 hours (especially monitoring blood pressure, injection frequency, conduction disorders, signs of severe heart failure).

Maximum doses recommended: 10 mg/day/day.

The adjustment dose does not have to follow the clinical response but according to the level of tolerance to the target dose, in some patients may appear side effects, so it is impossible to achieve the maximum recommended dose. If necessary, the dose must gradually reduce. In case of necessity, it is necessary to stop treatment, then continue treatment again. During the dose adjustment period, when the heart failure worsens or is not tolerated, it is necessary to reduce the dose, even stop treating immediately if needed (severe blood pressure, severe heart failure accompanied by acute pulmonary edema, cardiac shock, bradycardia or atrial - ventricular block).

Treatment of stable chronic heart failure with Bisoprolol Fumarat is a long -term treatment, not suddenly stopped, which can cause heart failure. If it is necessary to stop, gradually reduce the dose, divide the dose half a week.

Dosage for patients with liver failure and kidney failure

start Bisoprolol Fumarat dose 2.5 mg/day and slowly increase above patients with severe hepatic impairment or renal failure (creatinine clearance

Elderly

No need to adjust the dose.

Children

There is no data. Unsired for children.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? The doctor will give the necessary treatment plan.

Symptoms of overdose may be dizziness, head scum, shortness of breath or wheezing. In addition, it may include slow heart rate, hypotension, poor heart activity, hypoglycemia (may be related to the feeling of hunger, sweating, suspense).

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Corbis 5 mg Efroze 2x10, you may experience unwanted effects (ADR).

Common (ratio

Fatigue, dizziness, headache.

Feeling cold or numbness of hands and feet.

Hypotension.

Having stomach or intestinal problems such as nausea, vomiting, diarrhea or constipation.

Uncommon (ratio

Sleep disorder.

Depression.

Difficulty breathing in patients with asthma or chronic lung disease.

Mechanical weakness, easy cramping.

Rare (ratio

The problem of ears.

allergic runny nose.

dry eyes (may be trouble if using contact lenses).

Hepatitis, which can cause jaundice or whites. allergies: itching, rash.

Reduce sexual ability.

Nightmare, hallucinations, fainting.

Very rare (ratio

irritation or red eyes (conjunctivitis).

Hair loss.

Appears or worsens psoriasis, rashes, psoriasis.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Corbis 5 mg Efroze2x10 contraindicated in the following cases:

Bisoprolol Fumarat is contraindicated in patients with cardiac shock, acute heart failure, untreated heart failure by foundation treatment, heart failure III or IV, atrial block - second or three, and sinus bradycardia (below 60/minute before treatment).

Hypersensitivity to bisoprolol fumarat or any ingredients of the drug.

Asthma or chronic lung disease.

There is a problem with blood circulation in the limb (such as Raynaud's syndrome), which can cause itching or pale or blue transfer.

Chrome -preferred cells are not treated (a rare tumor form in the adrenal gland).

Metabolic acidosis.

Do not use Corbis 5 mg Efroze 2x10 tablets if there are one of the following cardiovascular problems: Heart failure suddenly worsened or may require treatment at the hospital, the heart rate is slow or irregular, very low blood pressure.

Precautions when using

If it is one of the following cases, notify the doctor before using the 5 mg Efroze 2x10 tablet, the doctor may have a particularly careful treatment regime (adding treatment conditions or performing more frequent tests):

diabetes (bisoprolol fumarat can hide the symptoms of hypoglycemia).

vegetarianism is too strict.

Heart disease such as arrhythmia or angina (Prinzmetal angina).

Psoriasis history.

Bisoprolol fumarat can hide symptoms of hyperthyroidism).

If you stop using Bisoprolol Fumarat tablets

Do not stop using the Bisoprolol Fumarat tablet without a doctor's opinion. If not, it will worsen the condition.

If you need more information about using this product, consult your doctor or pharmacist.

The ability to drive and operate machinery

The ability to drive or use machines may be affected depending on the body's response. Especially cautious when starting treatment, increasing dose or when changing, when used with alcohol.

Pregnancy

Using Corbis 5 mg Efroze 2x10 tablets during pregnancy can be harmful to the fetus. If you are pregnant or plan to get pregnant, notify your doctor, the doctor will decide that you can use Corbis 5 mg Efroze 2x10 tablet during pregnancy.

Breastfeeding period

There is no data on bisoprolol fumarat excretion through breast milk. Therefore, breastfeeding is not recommended during the treatment with Corbis 5 mg Efroze 2x10 tablet.

Drug interaction

Do not use the following drugs with Corbis 5 mg Efroze 2x10 tablets without a doctor's advice:

Some drugs used to treat arrhythmia (drugs such as quinidine, disopyramid, lidocaine, phenytoin, flecainid, propafenon).

Some drugs treat high blood pressure, angina or irregular heart rate (calcium channel blockers such as verapamil, diltiazem).

Some drugs used to treat high blood pressure such as Clonidin, Methyldopa, Moxonidin, Rilmenidin.

consult your doctor before taking the following drugs with Bisoprolol Fumarat, the doctor may have to check the patient's condition more often.

Some drugs used to treat high blood pressure or angina (felodipine and amlodipine).

Some drugs used to treat arrhythmia (amiodaron).

Timolol eye drops and drugs related to glaucoma treatment.

Some medications to treat Alzheimer or glaucoma (such as tacrin or carbachol) or drugs to treat acute heart diseases such as isoprenalin and dobutamin.

Diabetes treatments include insulin.

Anesthesia agents such as during surgery.

Digoxin is used to treat heart failure.

Non -steroid anti -inflammatory drugs: ibuprofen, diclofenac.

Anti -blood pressure drugs, antidepressants such as imipramin or amitriptylin, some drugs used in the treatment of epilepsy or anesthesia (phenobarbital) or some psychotropic drugs (levomepromazin).

Mefloquin is used to prevent and treat malaria.

Imao (except for Mao-B inhibitors) like moclobemid.

Some medications to treat migraine such as ergotamine.

Storage

Protection from sunlight, temperature and humidity, below 30 ° C.

Other drugs

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