Cortibion Roussel skin cream treatment for eczema, insect bites, contact dermatitis, atopic dermatitis (8g)

Dosage form Bottle
Specifications Chloramphenicol, dexamethasone acetate
Ingredient Roussel

Ingredient

Composition information	Content
Chloramphenicol	0.16
Dexamethasone acetate	4mg

Uses

Indications

Cortibion drug is indicated in the following cases:

Treatment of skin diseases responds to local corticosteroids and superinfection such as eczema, sebum secretion, atopic dermatitis.

Pharmacokology

Chloramphenicol often has a bactericidal effect, but can kill bacteria at high concentrations or for highly sensitive bacteria.

chloramphenicol inhibits protein synthesis in sensitive bacteria by attaching to the mini of the ribosom 50s. The drug has the same position with Erythromycin, Clindamycin, Lincomycin, Oleandomycin and Troleandomycin. Chloramphenicol has almost no effect on Escherichia Coli, Shigella Flexneri, Entobacfer spp.

Chloramphenicol does not work for mushrooms. Dexamethason is fluenceylprednisolon, synthetic glucocorticoid. The glucocorticoids act on the receptor in the cell, the transfusion into the cell nucleus and there has affected some of the translated genes. Glucocorticoids also have some direct effects, may not be intermediaries connected to the receptor. Dexamethasone has the main effects of glucocorticoids are anti -inflammatory, anti -allergic and immunosuppressive inhibition, while the effect of electrolyte balance is very few. In terms of anti -inflammatory activity, Dexamethason is stronger than Hydrocortisone, 7 times stronger than prednisolon.

pharmacokinetic

chloramphenicol is quickly absorbed through the digestive tract. Chloramphenicol is drained mainly in the liver due to glucuronyl transferase. Chloramphenicol excreted mainly in urine. A small amount of chloramphenicol in the form of unchanged excretion in bile and stool after taking the drug.

well -absorbed corticosteroids from the gastrointestinal tract, and are also well absorbed at the position of the drug and then distributed into all tissues in the body, dexamethasone through the placenta and a small amount through milk. Dexamethason is also linked to plasma proteins (up to 77%) and mainly albumin. The drug is highly absorbed in the liver, kidneys and adrenal glands. Metabolism in the liver slowly and excreted mainly through urine, most in the form of non -conjugate steroids.

Before taking Cortibion Roussel skin cream treatment for eczema, insect bites, contact dermatitis, atopic dermatitis (8g)

How to use

Use on the skin.

Dosage

Apply thin layer 1-2 times/day.

Do not take more than 8 days for a treatment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Unless the patient is too sensitive to corticosteroids, causing pathology, at which time it is necessary to treat symptoms.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Cortibion, you may experience unwanted effects (ADR).

If used for a long time, unwanted side effects may be:

Common

Electrolyte disorders: Hypotension, sodium and edema.

Endocrine and metabolism: Cushing syndrome, ACTH excretion, adrenal atrophy, glucid tolerance, menstrual disorders.

Muscle muscle: Muscle atrophy recovery, osteoporosis.

digestive: vomiting, diarrhea, peptic ulcer, acute pancreatitis. Skin: Skin atrophy, erythema, him.

nerve: insomnia, refreshment.

Less

urticaria, headache, granulocytopenia, hypoglycemia, hypersensitivity, sometimes anaphylaxis, white blood cells, blood thrombosis, weight gain, appetite, nausea, hard -working, hiccup, sterile abscess.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cortibion drug is contraindicated in the following cases:

Systemic fungal infection, local virus infection or bacterial infection.

Severe destruction of joints.

ulcerative lesions, acne, red nose.

Increase colds with dexamethason or chloramphenicol or other components of the formula.

Babies, emulsion.

Caution when using

Do not apply thick layer, on a large scale, closed icy, eyelid, breast area in nursing women.

Do not apply to the face unless the doctor is indicated.

Local used chloramphenicol can also cause serious harmful reactions so it is necessary to avoid abuse and avoid long -term use.

The ability to drive and operate machinery

does not affect.

Pregnancy

chloramphenicol easily passes through the placenta. Do not use chloramphenicol for pregnant women near the birth period or during labor because it may occur toxic effects on the fetus (for example, gray syndrome is a cardiovascular collapse that occurs in premature babies and babies when using chloramphenicol). Glucocorticoid can also inhibit the adrenal glands in babies if the mother uses a prolonged drug.

breastfeeding period

chloramphenicol is distributed into the milk. Be careful for mothers to breastfeed because of the toxic effects on infants and breastfeeding. Dexamethason into breast milk and at risk for breastfeeding.

Drug interaction

has not recorded any cases.

To avoid possible interactions, always inform the doctor or pharmacist of all other drugs in use.

Storage

In a dry place, temperatures below 30 ° C, avoid light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Cortibion ​​Roussel skin cream treatment for eczema, insect bites, contact dermatitis, atopic dermatitis (8g)