Coryol 12.5mg Krka medicine for hypertension (4 blisters x 7 tablets)

Dosage form Box of 4 blisters x 7 tablets
Specifications Carvedilol
Ingredient Hypertension, back pain

Ingredient

Composition information	Content
Carvedilol	12.5mg

Uses

indications

Coryol 12.5mg indications for treatment in the following cases:

Hypertension; Carvedilol can be used alone or in combination with other drugs, especially with thiazid diuretics. other).

pharmacokinetics

No data.

Before taking Coryol 12.5mg Krka medicine for hypertension (4 blisters x 7 tablets)

How to use

To reduce the potential of the risk of decreased vertical blood pressure, Coryol is recommended to be used with food.

Dosage

In the treatment of hypertension:

The first dose of 12.5 mg, taken once a day; increased to 25 mg after 2 days, drink once a day. Fruit.

In the treatment of angina:

The first dose of 12.5 mg, taken 2 times a day; After 2 days of increasing to 25 mg, 2 times a day.

In the treatment of heart failure:

Take the dose of 3,125 mg orally twice a day for 2 weeks. The dose may increase if tolerant, at least the next 2 weeks are recommended for 25 mg, 2 times a day, for patients who need to be less than 85 kg or 50 mg, taken twice a day, for people weighing over 85 kg. The risk of heart failure and//or decreased severe severe blood pressure in the first 30 days of treatment.

Adjust the dose in people with renal failure: Unnecessary.

urine adjustment in liver failure: Contraindications.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Coryol has been rated as safe for patients with heart failure (mild, medium and severe) or in hypertension.

However, some reports have recorded unwanted effects that can be encountered when using Coryol.

Most of the unwanted effects are temporary and after a while. Most of these effects occur at the beginning of treatment.

Unwanted effects are mainly related to pharmacological mechanisms and dose. The most common is dizziness (about 10%) and headache (about 5%).

Common, ADR> 1/100

Systemic: headache, muscle aches, fatigue, shortness of breath

circulatory: Slow heart rate.

Blood: platelet increasing, leukopenia,

circulatory: poor air conditioning, fainting. Tears, irritation.

can minimize the risk of heart rate slow and other undesirable effects by starting treatment at low doses, then gradually increasing the dose, careful monitoring of diastolic blood pressure measurements and heart frequency, and taking carvedilol consolidated food.

Need to reduce the dose if the circuit frequency drops below 55 hours of dam. Avoid stopping the drug suddenly.

Patients must avoid standing up suddenly or standing still for a long time, need to lie down, if dizzy or go, and consult a physician about the dose reduction.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Coryol 12.5mg contraindicated drug in the following cases:

Unbelgended congestive heart failure (level III - IV according to NYHA heart failure classification).

Be cautious when using

Carvedilol caution in patients with congestive heart failure treated with digitalis, diuretics, or enzyme inhibitors that transferred angiotensin because the atrial transmission may be slowed down.

Be careful in patients with diabetes with no or difficult to control, because beta receptor blockers can cover symptoms of blood glucose.

Must stop treatment when there is signs of liver damage.

Must be cautious in people with peripheral blood vessels, people with anesthesia, people with increased thyroid function.

If the patient does not tolerate other anti -hypertension drugs, caution can be used with very small doses of carvedilol for people with bronchospasm.

Avoid stopping the drug suddenly, to stop the drug for 1-2 weeks.

Consider the risk of arrhythmia, if using carvedilol simultaneously with anesthetic smell.

Must consider the risk if combining Carvedilol with anti -arrhythmia group I.

Not yet determined the safety and effectiveness of Carvedilol in children.

Drug interaction

like other sympathetic beta inhibitors, carvedilol may increase the effect of drugs for hypertension or adverse effects to cause hypotension.

Like other beta inhibitors, should be cautious when using carvedilol with anti -arrhythmic drugs or calcium antagonists like Verapamil or Diltiazem. Some cases of conduction disorders when using Carvedilol simultaneously with diltiazem.

Therefore, intravenously, calcium inhibitors and anti -arrhythmic drugs during treatment with Carvedilol.

When carvedilol is discontinued with clonidin, carvedilol should be discontinued a few days before gradually decreasing clonidin.

When using Carvedilol and Digoxin, the peak concentration in the stable state of digoxin can increase by about 16% in hypertension patients. Digoxin concentration should be enhanced at the beginning of treatment, adjusting the dose or stopping carvedilol.

Carvedilol's interaction with CYP2D6 inhibitors such as Quinidin, Fluoxetin and Paroxetin drugs have not been studied, but these drugs are probably increased the concentration of optical isomers R (+) of carvedilol in the blood.

Carvedilol can increase the hypoglycemic effect of insulin and oral hypoglycemic drugs. Symptoms of hypoglycemia may be covered or reduced (especially fast heart symptoms).

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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